Metabolic syndrome and selenium in fetal programming: gender differences

Abstract

Se balance and Se tissue deposits in MS pups during lactation are altered by gender. This difference is focused on hepatic Se deposits that affect GPx activity, which could be related to a disruption in the insulin-signaling cascade in females. Furthermore, although female fructose pups had greater metabolic disorders, only the males' growth and development were affected. Particularly relevant is the depletion of Se found in the heart of fructose pups, as this element is essential for correct heart function.

<p>The negative and detrimental effects of high fructose on the liver, with special reference to metabolic disorders</p>

“…Additionally, it should be noted that there are likely many other factors that contribute towards the magnitude of the effects of fructose which should be taken into consideration, such as physical inactivity and other dietary components, as well as gestation and lactation periods which lead to deep metabolic changes in mothers and in their progeny via metabolic early programming. For instance, it has been reported that severe hepatic damage occurred in dams and in their offspring after a high fructose diet 42,43. Further research with larger clinical trials that examine the effects of lowering HCFS and sugar consumption as well as uric acid levels is warranted to confirm the impact of fructose on health.…”

Heart selenoproteins status of metabolic syndrome-exposed pups: A potential target for attenuating cardiac damage

“…In a recent previous work, we have demonstrated in an in vivo model of MS induced by a fructose-rich diet in dams, as well as in their lactating pups, that Se liver deposits and GPx1 expression and activities increased, contributing to the evolution of IR [6,7], as they alter the insulin signaling cascade [8]. However, despite the fact that Se serum levels remained unaltered after fructose exposure, Se deposits in heart were significantly, and surprisingly, reduced in dams and in their offspring.…”

Maternal Selenium and Developmental Programming

“…Recently, the role of Se in metabolic programming has gained interest [45]. This micronutrient, through the activity of selenoproteins, such as glutathione peroxidase and selenoprotein P, has been reported to play a role in the regulation of enzymes in the insulin signaling cascade, the expression of lipogenic enzymes, and carbohydrate metabolism in the liver [46,47,48].…”