Associations between arterial stiffness, depressive symptoms and cerebral small vessel disease: cross-sectional findings from the AGES-Reykjavik Study

Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study

“…Aortic stiffness was associated with both a depressive disorder and depressive symptoms in The Rotterdam Study 10 and with depressive symptoms in the AGES-Reykjavik Study, as diagnostic interviews were not available. 11 The observed associations were, however, relatively small compared with our results in individuals aged 60 years or younger. It may be plausible to assume that the association between aortic stiffness and depression may be overshadowed in later life by the development of CVD, especially in individuals at risk owing to greater aortic stiffness.…”

“…Although the association was significant only in middle-aged men, we cannot rule out the presence of an association in middle-aged women. Only a few previous large cross-sectional studies carried out interaction analyses for sex, [10][11][12] and none reported any significant differences. However, the mean age of these study populations was 70 years or older, whereas our observed sex interaction occurred in patients aged 60 years or younger.…”

“…A significant association between aortic stiffness and depression was observed in the population-based Rotterdam Study 10 and the AGES-Reykjavik Study, 11 whereas no association was found with depressive symptoms in the Health ABC Study. 12 This contradiction could be explained by differences in the age range between these study populations (≥ 55 yr in the Rotterdam Study v. 70-79 yr in the Health ABC Study), and by the use in the latter study of questionnaire data, which are less accurate than a diagnostic interview, as an estimate of depressive symptoms.…”

“…Conflicting results have been reported on the association between aortic stiffness and both the presence of major depressive disorder (MDD) [8][9][10] and depressive symptoms, 11,12 which may be explained by suboptimal study designs and/ or assessment of arterial stiffness and depression. A significant association between aortic stiffness and depression was observed in the population-based Rotterdam Study 10 and the AGES-Reykjavik Study, 11 whereas no association was found with depressive symptoms in the Health ABC Study.…”

Influence of Combination Antihypertension Therapy on the Parameters of Vessel Wall Rigidity in Non-Controlled Arterial Hypertension Patients With Depression

“…Так, в исследовании Van Sloten TT, et al, установлена прямая корреляционная связь между дли-тельностью, тяжестью ДР и показателями артериаль-ной ригидности [16]. Предполагается, что на фоне депрессии снижается выработка оксида азота, повы-шается синтез провоспалительных цитокинов, что способствует повышению жесткости сосудистой стенки.…”