Influence of Combination Antihypertension Therapy on the Parameters of Vessel Wall Rigidity in Non-Controlled Arterial Hypertension Patients With Depression

Скибицкий, В. В.; Скибицкий, А. В.; Фендрикова, А. В.

doi:10.15829/1560-4071-2016-4-76-82

Cited by 4 publications

(3 citation statements)

References 11 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…показано, что успешное лечение антидепрессантом сопровождалось улучшением функции эндотелия и уменьшением сосудистой жесткости у больных депрессией, независимо от наличия АГ [19]. Единичные исследования свидетельствуют и о регрессе параметров ЦАД на фоне применения селективных ингибиторов обратного захвата серотонина у лиц с АГ и ТДР [5]. Изложенное объясняет статистически значимое улучшение показателей сосудистой жесткости и ЦАД, продемонстрированное в нашей работе.…”

Section: Discussionunclassified

“…Несмотря на то, что сочетание АГ и ТДР часто встречается в клинической практике, однозначные рекомендации по ведению данной категории больных отсутствуют. Имеется небольшое количество исследований, посвященных комплексной антигипертензивной и психотропной фармакотерапии [5]. В то же время остается неясным, будет ли иметь такая комбинированная терапия преимущества перед традиционной в отношении усиления антигипертензивного эффекта, влияния на основные показатели суточного профиля АД, центрального аортального давления (ЦАД) и сосудистой жесткости, улучшения когнитивных функций (КФ).…”

Section: Introductionunclassified

See 1 more Smart Citation

Combined antihypertensive and psychocorrective therapy in patients with arterial hypertension and anxiety-depressive disorders: are there any advantages?

et al. 2021

View full text Add to dashboard Cite

Relevance. Arterial hypertension (AH) and anxiety-depressive disorders (ADD) are comorbid pathologies that are common in clinical practice. At the same time, the possibility of including an antidepressant in antihypertensive therapy for optimal control of hypertension, as well as to ensure a vasoprotective effect, has not been studied enough. Aim. To compare the effect of traditional antihypertensive therapy and therapy, including an antidepressant, on indicators of the daily profile of blood pressure (BP), stiffness of the vascular wall and central aortic pressure (CAP), the severity of anxiety and depression, as well as on cognitive function (CF) in patients AH and ADD. Materials and methods. The study included 90 patients with AH and ADD, who were randomized into two groups: group 1 patients who received a fixed combination of an angiotensin II receptor blocker and a diuretic, a b-blocker and an antidepressant; group 2 persons who took only three-component antihypertensive therapy. Before and after 24 weeks, all patients underwent a general clinical examination, 24-hour BP monitoring ABPM (BpLab Vasotens, Petr Telegin, Russia) with an assessment of the daily profile of BP, CAP and vascular stiffness. In addition, testing was carried out on the HADS, CES-D scales; CF were rated according to the Montreal scale. Results. In the group of patients treated with an antidepressant, it was noted that the target BP level was achieved more quickly when lower doses of angiotensin II receptor blockers were prescribed. After 6 months of therapy in both groups, there was a comparable positive dynamics of the main indicators of ABPM. In group 1, a statistically more pronounced decrease in both peripheral and CAP at night was recorded. In both groups of patients, a decrease in the augmentation index was noted; however, a statistically significant improvement in the parameters of the speed of propagation of the pulse wave in the aorta and the time of propagation of the reflected wave was recorded only in persons receiving antidepressant. In group 1, there was a regression of ADD, as well as a significant improvement in CF. Conclusions. The use of sertraline as part of a combination antihypertensive therapy in patients with AH and ADD contributed to a more rapid achievement of target BP values, a significant improvement in ABPM (especially at night), vascular wall stiffness and CAP. It is also important that the appointment of sertraline was accompanied by a regression of anxiety-depressive symptoms, an improvement in CF.

show abstract

Section: Discussionunclassified

Section: Introductionunclassified

Combined antihypertensive and psychocorrective therapy in patients with arterial hypertension and anxiety-depressive disorders: are there any advantages?

et al. 2021

View full text Add to dashboard Cite

show abstract

“…С учетом частого сосуще-ОРИГИНАЛЬНЫЕ СТАТЬИ § ствования АГ и депрессии в настоящее время активно изучаются и особенности изменения сосудистой стенки и ЦАД при подобном сочетании. Как правило, у пациентов с АГ и психоэмоциональными нарушениями имеются патологические изменения показателей, отражающих жесткость артерий [9,10]. Предполагается, что увеличение риска развития инсульта, ИМ у лиц с депрессией и сердечно-сосудистыми заболеваниями (ССЗ) во многом обусловлено именно негативными изменениями ригидности сосудов и повышением ЦАД [9].…”

Section: автор для перепискиunclassified

Gender Differences in Vascular Stiffness Indicators and Daily Blood Pressure Profile in Patients with Arterial Hypertension and Depressive Disorders

Фендрикова

Skibitskiy

2021

Kardiologiia

Self Cite

View full text Add to dashboard Cite

Aim To study gender-related characteristics of vascular wall stiffness (VWS), central blood pressure (CBP), and BP diurnal profile in patients with arterial hypertension (AH) and depression.Material and methods This prospective, noninterventional study enrolled 161 patients, including 98 patients with AH and depression (50 (51 %) men and 48 (49 %) women) and 63 patients with AH without depression (32 (50.8 %) men and 31 (49.2 %) women. The 24-h BP monitoring (24-h BPM) with a BPLab Vasotens hardware system was performed for all patients. The following indexes were evaluated: mean diurnal, mean daytime, and mean nighttime systolic and diastolic BP (SBP and DBP); daytime and nighttime SBP and DBP time index; SBP and DBP variability; and suite of metrics characterizing VWS and CBP. Depression was diagnosed with the Hospital Anxiety and Depression Scale (HADS) and the Zung Self-Rating Depression Scale. Statistical analyses were performed using the STATISTICA 12 software.Results In the patient group with AH and depression, practically all indexes of 24-h BPM were higher for men than for women (р<0.05). Most 24-h BPM parameters did not differ in groups of men and women without depression. Independent of gender, 24-h BPM parameters were significantly higher in patients with both AH and depression than in AH patients without depression. Adverse changes in major indexes of VWS and CBP, were more pronounced in men than in women with AH and depression (р<0.05). Adverse changes in most VWS and CBP indexes were more statistically significant for men with AH and depression than for men without depression.Conclusion The presence of depression in men and women with AH was associated with significant pathological changes in both BP diurnal profile and CBP and VWS parameters. Furthermore, adverse changes in indexes were more pronounced for men with depression than for women. The study results should be taken into account in administration of antihypertensive and psychocorrective drug therapy to personalize the treatment and provide not only optimization of diurnal BP profile but also vasoprotection.

show abstract

Depression as a predictor of high arterial stiffness in patients with low/moderate risk of cardiovascular complications

Smirnova,

Svirida,

Blankova

et al. 2023

Kardio. vestn.

View full text Add to dashboard Cite

Influence of Combination Antihypertension Therapy on the Parameters of Vessel Wall Rigidity in Non-Controlled Arterial Hypertension Patients With Depression

Cited by 4 publications

References 11 publications

Combined antihypertensive and psychocorrective therapy in patients with arterial hypertension and anxiety-depressive disorders: are there any advantages?

Combined antihypertensive and psychocorrective therapy in patients with arterial hypertension and anxiety-depressive disorders: are there any advantages?

Gender Differences in Vascular Stiffness Indicators and Daily Blood Pressure Profile in Patients with Arterial Hypertension and Depressive Disorders

Depression as a predictor of high arterial stiffness in patients with low/moderate risk of cardiovascular complications

Contact Info

Product

Resources

About