Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study

Onete, Veronica G.; Henry, Ronald M.A.; Sep, Simone J. S.; Koster, Annemarie; Kallen, Carla; Dagnelie, Pieter C.; Schaper, Nicolaas C.; Köhler, Sebastian; Reesink, Koen D.; Stehouwer, Coen D. A.; Schram, Miranda T.

doi:10.1503/jpn.160246

Cited by 29 publications

(32 citation statements)

References 59 publications

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“…Smith and Singer argued over the role of AS in the bidirectional relationship between depression and CV morbidity in patients with MDD [3]. In the Maastricht study, Onete et al (12) evaluated MDD by using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9) in association with AS by determining PWV in a cohort of 2757 participants, and found that MDD and depressive symptoms, as well as AS were higher among middle-aged men, and to a lesser extent, in women. In our study we found no statistically significant differences between gender.…”

Section: Resultsmentioning

confidence: 99%

“…Khandoker et al, analysed the increased incidence of AS, as assessed solely by PWV and by PWV and Fingertip Photo-Plethysmography in smaller groups of depressed patients with suicidal intention, but without comorbid CVD (20). Other results of recent metaanalyses of prospective cohort studies, conducted on subjects that were initially free of CVD, indicate that depression was associated with a 30% increased risk of future coronar y events [10,12,13,21].…”

Section: Resultsmentioning

confidence: 99%

“…The consequence is an enhanced systemic vascular resistance (SVR) with elevated afterload, leading to LVH. The association between MDD, ED or AS was debated in numerous studies, highlighting the connections with the occurrence of atherosclerosis (10,12).…”

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confidence: 99%

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Impact of Therapy with Selective Serotonine-Reuptake Inhibitors on the Evolution of Subclinical Atherosclerosis in Patients with Depressive Disorder

Tudoran¹,

Giurgi-Oncu²,

Andor³

et al. 2019

Rev. Chim.

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The aim of this study is to highlight the impact of therapy with Sertraline on the AS alterations, in a group of 128 patients with MDD, but without significant CVD or risk factors for atherosclerosis. A secondary goal was to analyze whether there are statistically significant correlations between AS and the intensity of the current depressive episode, as assessed by using the Montgomery-Asberg Depression Rating Scale (MADRS), while also taking into account the duration of MDD.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Impact of Therapy with Selective Serotonine-Reuptake Inhibitors on the Evolution of Subclinical Atherosclerosis in Patients with Depressive Disorder

Tudoran¹,

Giurgi-Oncu²,

Andor³

et al. 2019

Rev. Chim.

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“…For example, Smith and Singer [5] debated the role of AS in the bidirectional relationship between depression and cardiovascular comorbidity in patients with MDD. In the Maastricht study, Onete et al [13] evaluated MDD by using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9). They studied the association with AS by determining PWV in a cohort of 2757 participants, and found that MDD and depressive symptoms, as well as AS were higher among middle-aged men, and to a lesser extent, in women.…”

Section: Discussionmentioning

confidence: 99%

“…Genetic factors may also play a significant role in the relationship between depression and CVD. There are assumptions that all these factors may induce the elevation of arterial stiffness (AS), followed by the development of SH and DD [12,13,14]. Several opinions in current literature suggest that there is a cumulative negative effect brought on by the exposure to repeated depressive episodes.…”

Section: Introductionmentioning

confidence: 99%

Aspects of diastolic dysfunction in patients with new and recurrent depression

Tudoran

Ciocârlie

et al. 2020

PLoS ONE

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ObjectiveThe main objective of this study was to evidence the potential impact of the intensity, duration and recurrence of depression on the development of arterial stiffness (AS) leading to left ventricular hypertrophy (LVH) and diastolic dysfunction (DD) in patients with new onset depression (NOD) and recurrent depression (RD) in comparison to 33 control subjects without depression. Another aim was to identify potential predictive factors regarding the occurrence of diastolic dysfunction (DD). MethodsOur study group included 58 patients diagnosed with NOD and 128 diagnosed with RD, without any previously diagnosed significant heart diseases. The intensity of depression was evaluated by means of the Montgomery-Asberg Depression Rating Scale (MADRS). Assessment of pulse wave velocity (PWV), left ventricular mass index (LVMI) and echocardiographic parameters characterizing DD were performed for each patient. ResultsThe cardiology evaluations suggested an increased prevalence of AS in all patients, of significantly higher rate than in controls (p<0.001), which was statistically correlated with the severity and duration of depression. Another significant finding was an increased prevalence of DD (29.31% and 63.28%, respectively; p<0.001) correlated with the MADRS score, total duration and number of recurrences/relapses. The multivariate logistic regression analysis identified PWV, the intensity and duration of depression as significant predictive factors for the occurrence of DD. ConclusionsIn our study, diastolic dysfunction was a common finding among patients with RD, but it was also noted, to a lesser extent, in those suffering with NOD. DD was associated with altered AS, and strongly correlated with the intensity and the duration of depressive symptoms. The

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Circulatory system alterations under stress

Chantler

Frisbee

2020

Cardiovascular Implications of Stress and Depression

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Arterial stiffness is associated with depression in middle-aged men — the Maastricht Study

Cited by 29 publications

References 59 publications

Impact of Therapy with Selective Serotonine-Reuptake Inhibitors on the Evolution of Subclinical Atherosclerosis in Patients with Depressive Disorder

Impact of Therapy with Selective Serotonine-Reuptake Inhibitors on the Evolution of Subclinical Atherosclerosis in Patients with Depressive Disorder

Aspects of diastolic dysfunction in patients with new and recurrent depression

Circulatory system alterations under stress

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