Aspects of diastolic dysfunction in patients with new and recurrent depression

Abstract

ObjectiveThe main objective of this study was to evidence the potential impact of the intensity, duration and recurrence of depression on the development of arterial stiffness (AS) leading to left ventricular hypertrophy (LVH) and diastolic dysfunction (DD) in patients with new onset depression (NOD) and recurrent depression (RD) in comparison to 33 control subjects without depression. Another aim was to identify potential predictive factors regarding the occurrence of diastolic dysfunction (DD). MethodsOur study group included 58 patients diagnosed with NOD and 128 diagnosed with RD, without any previously diagnosed significant heart diseases. The intensity of depression was evaluated by means of the Montgomery-Asberg Depression Rating Scale (MADRS). Assessment of pulse wave velocity (PWV), left ventricular mass index (LVMI) and echocardiographic parameters characterizing DD were performed for each patient. ResultsThe cardiology evaluations suggested an increased prevalence of AS in all patients, of significantly higher rate than in controls (p<0.001), which was statistically correlated with the severity and duration of depression. Another significant finding was an increased prevalence of DD (29.31% and 63.28%, respectively; p<0.001) correlated with the MADRS score, total duration and number of recurrences/relapses. The multivariate logistic regression analysis identified PWV, the intensity and duration of depression as significant predictive factors for the occurrence of DD. ConclusionsIn our study, diastolic dysfunction was a common finding among patients with RD, but it was also noted, to a lesser extent, in those suffering with NOD. DD was associated with altered AS, and strongly correlated with the intensity and the duration of depressive symptoms. The

Evolution of Heart Rate Variability and Heart Rate Turbulence in Patients with Depressive Illness Treated with Selective Serotonin Reuptake Inhibitors

“…ANS imbalance is associated with major depression, and alterations of HRV and HRT were frequently evidenced for this patient category in various medical studies [25][26][27]. It seems that the amplitude of HRV reduction matches the severity of depressive symptoms.…”

“…Data regarding the reversibility of HRV and HRT alterations under therapy with antidepressants are not entirely conclusive, with some studies evidencing further reductions of HRV during treatment. Nevertheless, in the case of SSRI therapy, notable improvements were evidenced in multiple studies [25][26][27][28]. However, we have highlighted the importance of early detection of mental health difficulties, when aiming to prevent and even treat CVD.…”

Assessment of the Impact of Alcohol Consumption Patterns on Heart Rate Variability by Machine Learning in Healthy Young Adults

“…Several findings evidenced a reduced HRV and cardiovascular diseases association, as expressed by lower values in the time-domain, in patients that are suffering from depression compared to healthy controls [ 50 , 51 , 52 , 53 ]. A meta-analysis based on 36 articles [ 54 ] showed that anxiety disorders are associated with lower HRV values.…”

Social Inferences as Mediators of Wellbeing in Depression

“…An adequate ToM, alongside neurocognition, ensures a good social functioning and adequate interpersonal relationships. 10 Recurrent depressive episodes are known to have an overabundance of critical negative consequences, not only impacting the physical health in various ways, 21 but also progressively leading to cognitive dysfunctions, which are detrimental to social functioning. 22 Certain clinical trials involving patients with chronic depressive disorders have shown an impairment in cognitive functioning, as well as emotional processing deficits/empathy that include ToM.…”