Associations Between 45t/G Polymorphism of the Adiponectin Gene and Plasma Adiponectin Levels With Type 2 Diabetes

Li, Linlin; Kang, Xiaolong; Ran, Xin; Wang, Ye; Wang, Changhui; Huang, Lin; Ren, Jun; Luo, Xin; Mao, Xinmin

doi:10.1111/j.1440-1681.2007.04713.x

Cited by 54 publications

(42 citation statements)

References 23 publications

(44 reference statements)

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“…This result corroborates with findings of the studies on Japanese population by Nakatani et al and Hara et al [4,8], on European population by Gable et al [9], on Spanish population by González-Sánchez et al [10], on Caucasian population by Menzaghi et al [11], in the DESIR study group by Fumeron et al [2], on the population of Uygurs of the Xinjiang region, China by Li et al [12] and in the STOP-NIDDM trial by Zacharova et al [14] .…”

Section: Discussionsupporting

confidence: 88%

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Adiponectin Gene Polymorphism and its Association with Type 2 Diabetes Mellitus

et al. 2011

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Mutations in different regions of adiponectin gene have been reported to be associated with obesity, atherosclerosis and type 2 diabetes mellitus. The present study was aimed to investigate the association among SNP 45 T [ G of adiponectin gene and type 2 diabetes in South Indian population. 75 clinically diagnosed case of type 2 diabetes were studied and compared with 75 apparently healthy controls. The genotype frequency of SNP45 T [ G in exon 2 of adiponectin gene was determined by PCR based restriction enzyme analysis using the restriction enzyme SmaI. (recognition site: CCC;GGG). Three kind of genotypes: wild type TT (470 bp), heterozygous type TG (470 bp, 336 bp, 134 bp) and homozygote mutant type GG (336 bp, 134 bp) were studied. A positive association has been found between SNP45 T [ G and type 2 diabetes in the study population (P = 0.010, OR = 3.797, 95% CI = 1.312-10.983). Therefore, SNP45T [ G in adiponectin gene may be one of the risk factors for type 2 diabetes.

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Section: Discussionsupporting

confidence: 88%

“…The study included 150 subjects in the age group of 40-70 years attending OPD of Sri Ramachandra Hospital, Porur Chennai. The sample size was selected following a similar study done on the population of Uygurs of the Xinjiang region, China by Li et al [12]. The control group and the cases consist of 75 subjects each (age and sex matched).…”

Section: Methodsmentioning

confidence: 99%

Adiponectin Gene Polymorphism and its Association with Type 2 Diabetes Mellitus

et al. 2011

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“…13 Compared with a normal glucose tolerance group, type 2 diabetes patients have been found to include more TG+GG genotypes at +45T/G, and type 2 diabetes patients carrying the G-allele had a lower insulin sensitivity index and higher insulin resistance index. 27 The adiponectin +276G/T SNP has been significantly correlated with the incidence of coronary heart diseases. 15 Moreover, homozygous individuals have a higher risk of coronary heart diseases.…”

Section: Discussionmentioning

confidence: 99%

Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

et al. 2010

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The etiology and pathogenesis of preeclampsia remain unclear. Little is known about the possible impact of adiponectin gene polymorphisms on the pathogenesis of preeclampsia. In this study, we analyzed the association of two adiponectin singlenucleotide polymorphisms (SNPs) with preeclampsia. One hundred eighty-eight Han Chinese pregnant women were enrolled (81 normal-term, 20 mild preeclampsia and 87 severe cases). Serum adiponectin level, and adiponectin exon 2 SNP +45T/G (rs2241766) genotype and intron 2 SNP +276G/T genotype (rs1501299) and their allele distributions were tested with enzyme-linked immunosorbent assay and PCR-restriction-fragment length polymorphism, respectively. There were no significant differences among the three groups (P40.05) in genotype distribution or allele frequencies of either SNP. Systolic pressure and 24-h urinary protein were lower in TT homozygotes than those in TG+GG patients at SNP +45T/G in the severe preeclamptic group (Po0.05). Furthermore, blood pressure, serum adiponectin level and 24-h urinary protein were lower in GG homozygotes than those in TG+TT patients at SNP +276G/T in the severe preeclamptic group (Po0.05). The risk of high blood pressure (X160/110 mm Hg) and of high serum adiponectin in T-allele carriers at +276G/T in the severe preeclamptic group were 5.345 and 5.818 times higher, respectively, compared with GG patients. These data suggest that adiponectin +45T/G and +276G/T polymorphisms are associated with important clinical manifestations of preeclampsia and that polymorphism +276G/T is associated with serum adiponectin level. Taken together, these findings suggest that adiponectin gene polymorphism is involved in the pathogenesis of preeclampsia.

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“…There are also diverse results about this relation in the literature. In some studies the G allele was found to be associated with higher LDL [17] and total cholesterol levels [17,29], fasting glucose [30,31], and HOMA-IR [17,32,33]. For example, Petrone et al [30] reported that the 45G carriers showed higher fasting and 2nd hour glucose levels compared with non-carriers in a population of overweight/obese children.…”

Section: Discussionmentioning

confidence: 99%

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2018

J Clin Anal Med

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Aim: Childhood obesity is increasing in incidence and is strongly associated with obesity in adulthood. Several studies to explain the role of genetics in the pathogenesis of obesity have been performed. The aim of this study was to investigate the relation between +45T>G single nucleotide polymorphism (SNP) and childhood obesity. Material and Method: 268 obese and 185 healthy (control) children and adolescents aged 6-17 years were enrolled. Laboratory tests including fasting glucose, insulin level, and lipid profile were drawn only from the obese participants. The +45T>G SNP in adiponectin gene was analyzed from the members of both groups by a polymerase chain reaction (PCR)-based restriction fragment length polymorphism (RFLP) method. Results: The genotype frequencies of the adiponectin gene for +45 locus in exon 2 were 77.9%, 19.1%, and 3% in obese subjects and 72.1%, 23.5%, and 4.4% in the control group for TT, TG, and GG respectively (p=0.357), with the allelic frequency of the G allele 12.5% in obese subjects and 16.1% in controls (p=0.129). When we compared different adiponectin genotypes, there wasn't any significant difference in frequencies of TT genotype (wild type) and non-TT (TG+GG) genotypes between the obese and control groups (p=0.162). Also, comparing GG genotype and non-GG (TG+TT) genotypes revealed no significant difference between the obese and control groups (p=0.439). Among obese subjects there were no significant relationships between different genotypes and clinical characteristics such as presence of hypertriglyceridemia, low high-density lipoprotein (HDL-C), hypertension, and insulin resistance. Discussion: In conclusion, in the present study, in a well-described obese and a control group of pediatric patients, we observed a lack of association between the +45T>G SNP and childhood obesity and its traits.

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Associations Between 45t/G Polymorphism of the Adiponectin Gene and Plasma Adiponectin Levels With Type 2 Diabetes

Cited by 54 publications

References 23 publications

Adiponectin Gene Polymorphism and its Association with Type 2 Diabetes Mellitus

Adiponectin Gene Polymorphism and its Association with Type 2 Diabetes Mellitus

Relationships among adiponectin gene polymorphisms, proteinuria and increased blood pressure in the context of placental diseases

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