Association of Vitamin D with Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis

doi:10.4328/jcam.2204

Cited by 6 publications

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“…For the secondary aim, fifty studies reported the proportion of vitamin D deficiency among 14 027 patients with pain conditions and 14 357 without ( 31 – 34 , 36 – 38 , 41 – 43 , 46 , 51 , 52 , 54 – 57 , 59 , 61 , 62 , 65 – 69 , 74 – 77 , 79 – 83 , 87 – 89 , 91 – 99 , 103 , 106 , 107 ) . One publication ( 76 ) reported results from two studies which are included separately in the current meta-analysis (Supplement 2, Supplementary Table 4).…”

Section: Resultsmentioning

confidence: 99%

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The association between vitamin D concentration and pain: a systematic review and meta-analysis

Wu¹,

Malihi²,

Stewart³

et al. 2018

Public Health Nutr.

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Section: Resultsmentioning

confidence: 99%

“…[54][55][56][57]59,61,62,[65][66][67][68][69][74][75][76][77][79][80][81][82][83][87][88][89][91][92][93][94][95][96][97][98][99]103,106,107) …”

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The association between vitamin D concentration and pain: a systematic review and meta-analysis

Wu¹,

Malihi²,

Stewart³

et al. 2018

Public Health Nutr.

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“…Studies conducted by Ibrahim et al .,[ 25 ] Yagiz et al . [ 26 ] and Kareem et al . [ 27 ] found significantly lower Vitamin D levels in patients with RA, SLE, ankylosing spondylitis, and Behcet's disease as compared to control population thus supporting the possible role of Vitamin D in the pathogenesis, activity and treatment of various autoimmune diseases.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Vitamin D in rheumatoid arthritis and its correlation with disease activity

et al. 2018

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Background:Vitamin D is believed to have an immunomodulatory and anti-inflammatory action, and its deficiency has been linked with several autoimmune disorders, including rheumatoid arthritis (RA). The relationship between the severity of RA and serum levels of Vitamin D is a subject of immense interest and therapeutic implications.Materials and Methods:This was a prospective, comparative study conducted on 100 participants, 50 cases of RA and 50 healthy controls, all in the age group of 18–75 years. Serum Vitamin D levels were measured and compared in cases and controls. Vitamin D levels in RA patients were also assessed in different stages of disease activity to assess the correlation between the two.ResultsEighty-four percent patients of RA were Vitamin D deficient versus only 34% of controls. The serum Vitamin D levels were also significantly lower in the RA patients (mean value of 21.05 ± 10.02 ng/ml), as compared to the controls (mean value of 32.87 ± 14.16 ng/ml). There was a significant inverse correlation between serum Vitamin D levels and RA disease activity. The mean serum Vitamin D levels were 35.28 ± 9.0 ng/ml, 33.80 ± 4.1 ng/ml, 22.47 ± 6.18 ng/ml, and 14.21 ± 6.97 ng/ml in the remission, low disease activity, moderate disease activity, and high disease activity groups, respectively.ConclusionsVitamin D deficiency is more common in RA patients and may be one of the causes leading to development or worsening of the disease.

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“…Studies conducted by Ibrahim et al [20] , Yagiz et al [21] and Kareem et al [22] found significantly lower Vitamin D levels in patients with RA, SLE, ankylosing spondylitis, and Behcet's disease as compared to control population thus supporting the possible role of Vitamin D in the pathogenesis, activity and treatment of various autoimmune diseases. Most of the patients with RA in our study were females (82%).…”

Section: Resultsmentioning

confidence: 89%

Role of vitamin d levels in rheumatoid arthritis and its correlation with disease severity

Aggarwal¹,

Gupta²,

Sreen³

et al. 2020

Int. J. Orthop. Sci.

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Objective: Deficiency of Vitamin D has been linked in the pathogenesis of many autoimmune diseases such as diabetes mellitus type 1 and multiple sclerosis. Deficiency of vitamin D has been associated with high susceptibility of the development of rheumatoid arthritis (RA) and also with increased disease activity in patients with RA. The objective of this study was to evaluate the status of vitamin D in patients with RA, assess the correlation between serum level of Vitamin D and disease severity. Materials and Methods: This was a prospective, comparative study conducted on 100 participants, 50 cases of RA and 50 healthy controls, all in the age group of 18-75 years. Serum Vitamin D levels were measured and compared in cases and controls. Results: Ninety two percent patients belonging to the RA group were Vitamin D deficient, whereas only twenty four percent belonging to the control group had Vitamin D deficiency. There was a significant inverse correlation between serum Vitamin D levels and RA disease severity. The mean serum Vitamin D levels were 34.36ng/ml,32.25±0.395ng/ml, 22.70±4.787ng/ml and 16.41±2.911ng/ml in the remission, low disease activity, moderate disease activity, and high disease activity groups, respectively. Conclusion: Vitamin D insufficiency and deficiency are more common in patients with RA. In this study Vitamin D deficiency was related to RA patients with older age, RA with female gender and a higher degree of RA activity.

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Association of Vitamin D with Disease Activity in Rheumatoid Arthritis and Ankylosing Spondylitis

Cited by 6 publications

References 24 publications

The association between vitamin D concentration and pain: a systematic review and meta-analysis

The association between vitamin D concentration and pain: a systematic review and meta-analysis

Assessment of Vitamin D in rheumatoid arthritis and its correlation with disease activity

Role of vitamin d levels in rheumatoid arthritis and its correlation with disease severity

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