Association of Tumor Necrosis Factor-alpha Polymorphisms and Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease

Cheng, Yu‐Ting; An, Baiquan; Jiang, Man; Xin, Yongning; Xuan, Shi‐Ying

doi:10.5812/hepatmon.26818

Cited by 29 publications

(20 citation statements)

References 41 publications

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“…This is in accordance with the study by Cheng et al conducted to evaluate the association of TNF-α polymorphisms with the risk of developing coronary artery disease (CAD) in NAFLD patients, which also reported that NAFLD patients without CAD who were carriers of the GA genotype had higher serum triglycerides levels compared to those with the GG genotype (p = 0.017) [48].…”

Section: Discussionsupporting

confidence: 90%

PNPLA3 and TNF-<i>α</i> G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

Hegazy¹,

Samie²,

Ezzat³

et al. 2016

OJGas

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Introduction: There is growing evidence that genetic and environmental factors play an important role in the development and progression of non-alcoholic fatty liver disease (NAFLD). We investigated the association of single nucleotide polymorphism (SNP) rs738409 in PNPLA3 gene and TNF-α G238A polymorphism with the development and severity of NAFLD in an overweight and obese Egyptian population. Material and Methods: 100 overweight and obese patients with NAFLD and 30 control subjects were enrolled. All NAFLD patients underwent a confirmatory biopsy. Laboratory investigations included fasting plasma glucose, kidney and liver function tests, liver enzymes, lipid profile and hepatitis markers. Abdominal ultrasound was performed and all subjects were genotyped for (rs738409) PNPLA3 and (rs361525) TNF-α gene polymorphisms using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Results: The homozygous GG genotype of the PNPLA3 was most frequent among patients with NASH (26%) as compared to borderline NASH (20.5%) and simple steatosis (20%). Higher serum levels of transaminases were observed in NAFLD patients and controls who were carriers of the G allele of rs738409, but this was not statistically significant. Regarding the TNF-α G238A SNP; the frequency of the A allele was significantly higher in NAFLD patients (20%) compared to controls (5%) (p value = 0.006). The highest TNF G allele frequency was observed in the NASH group (88%) and this was statistically significant (p value = 0.009). Conclusion: Our study confirmed the association of the PNPLA3 (rs738409) and TNF-α promoter region G238A polymorphisms with susceptibility to NAFLD and its progression. M. A. Hegazy et al.54

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Section: Discussionsupporting

confidence: 90%

PNPLA3 and TNF-<i>α</i> G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

Hegazy¹,

Samie²,

Ezzat³

et al. 2016

OJGas

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“…The complete full texts of the remaining 89 articles were assessed, excluding 64 articles that did not meet the study inclusion criteria. Reasons for exclusion of these studies were theoretical research [3], lack of clinical outcomes [10], duplicate articles [5], and lack of a control group [11]. We ultimately identified a total of 25 case-control studies that met the inclusion criteria for this meta-analysis, including 7697 patients in the CAD group and 9655 in the control group.…”

Section: Overview Of Included Studiesmentioning

confidence: 99%

Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Huang

Zhao

et al. 2020

BMC Med Genet

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Background: The goal of this study was to review relevant case-control studies to determine the association of tumor necrosis factor-α (TNF-α) gene polymorphisms and coronary artery disease (CAD) susceptibility. Methods: Using appropriate keywords, we identified relevant studies using PubMed, Cochrane, Embase, CNKI, VANFUN, and VIP. Key pertinent sources in the literature were also reviewed, and all articles published through April 2019 were considered for inclusion. Based on eligible studies, we performed a meta-analysis of association between 308G/A, 238G/A, 857C/T, 863C/A and 1031 T/C polymorphisms in TNF-α and risk of CAD. Results: We found 25 studies that were consistent with this meta-analysis, including 7697 patients in the CAD group and 9655 control patients. TNF-α 308G/A locus A showed no significant association with CAD susceptibility by the five models in the analysis of the overall population, European, African, South Asian, and North Asian patients. TNF-α 863C/A locus A and 1031 T/C locus C exhibited no significant association with CAD susceptibility. TNF-α 238G/A locus A had no significant association with CAD susceptibility in the overall population. However, TNF-α 238G/A locus A showed significant association with higher CAD susceptibility in the subgroup of Europeans and north Asians. TNF-α 857C/T locus T had no significant association with CAD susceptibility in the analysis of the overall population and Europeans. In the north Asian population, TNF-α 857C/T locus T was associated with lower CAD susceptibility by the heterozygote model. Conclusion: TNF-α 308G/A, 857C/T, 863C/A, and 1031 T/C has no significant association with CAD susceptibility. TNF-α 238G/A locus A has significant association with CAD susceptibility in Europeans and north Asians, but has no significant association in the overall population. Studies with a larger sample size are required to confirm the association between TNF-α 238G/A and CAD susceptibility.

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“…TNF-α -308 GA heterozygote genotype was positively associated with elevated levels of TG in NAFLD patients with CAD. Then obtained the conclusion that TNF-α -308 GA genotype plays a crucial role in the development of CAD in NAFLD patients [ 93 ].…”

Section: Tumor Necrosis Factors-alpha Gene ( Tnf-α mentioning

confidence: 99%

Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

Sui

et al. 2016

Lipids Health Dis

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Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease which represents a wide spectrum of hepatic damage. Several studies have reported that NAFLD is a strong independent risk factor for coronary artery disease (CAD). And patients with NAFLD are at higher risk and suggested undergoperiodic cardiovascular risk assessment. Cardiovascular disease (CVD) is responsible for the main cause of death in patients with NAFLD, and is mostly influenced by genetic factors. Both NAFLD and CAD are heterogeneous disease. Common pathways involved in the pathogenesis of NAFLD and CAD includes insulin resistance (IR), atherogenic dyslipidemia, subclinical inflammation, oxidative stress, etc. Genomic characteristics of these two diseases have been widely studied, further research about the association of these two diseases draws attention. The gene polymorphisms of adiponectin-encoding gene (ADIPOQ), leptin receptor (LEPR), apolipoprotein C3 (APOC3), peroxisome proliferator-activated receptors (PPAR), sterol regulatory elementbinding proteins (SREBP), transmembrane 6 superfamily member 2 (TM6SF2), microsomal triglyceride transfer protein (MTTP), tumor necrosis factors-alpha (TNF-α) and manganese superoxide dismutase (MnSOD) have been reported to be related to NAFLD and CAD. In this review, we aimed to provide an overview of recent insights into the genetic basis of NAFLD and CAD.

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Association of Tumor Necrosis Factor-alpha Polymorphisms and Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease

Cited by 29 publications

References 41 publications

PNPLA3 and TNF-<i>α</i> G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

PNPLA3 and TNF-<i>α</i> G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

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Association of Tumor Necrosis Factor-alpha Polymorphisms and Risk of Coronary Artery Disease in Patients with Non-alcoholic Fatty Liver Disease

Cited by 29 publications

References 41 publications

PNPLA3 and TNF-&lt;i&gt;α&lt;/i&gt; G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

PNPLA3 and TNF-&lt;i&gt;α&lt;/i&gt; G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

Association of tumor necrosis factor-α gene polymorphisms and coronary artery disease susceptibility: a systematic review and meta-analysis

Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

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Product

Resources

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PNPLA3 and TNF-<i>α</i> G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD

PNPLA3 and TNF-<i>α</i> G238A Genetic Polymorphisms in Egyptian Patients with Different Grades of Severity of NAFLD