Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

Li, Xin; Sui, Jian-Qing; Lu, Linlin; Zhang, Nannan; Xu, Xin; Dong, Qiu‐Ting; Xin, Yongning; Xuan, Shi‐Ying

doi:10.1186/s12944-016-0221-8

Cited by 38 publications

(27 citation statements)

References 94 publications

(95 reference statements)

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“…There is a firm justification for MD in NAFLD patients also in terms of primary prevention of related diseases . Although NAFLD patients may represent a genetically high risk population for CVD, a healthy lifestyle can still benefit them; analysis of joint prospective cohorts involving 55 685 participants demonstrated that adherence to a reasonably achievable healthy lifestyle defined as at least 3 of the 4 following criteria: no current smoking, no obesity, regular physical activity (at least once weekly), and a healthy diet (adherence to at least half of the MD characteristics) was associated with 46% lower relative risk of coronary events among participants at high genetic risk …”

Section: Summary and Practical Implicationsmentioning

confidence: 99%

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Zelber‐Sagi

Salomone²,

Mlynarsky

2017

Liver International

190

150

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Non-alcoholic fatty liver disease (NAFLD) has become a major global health burden, leading to increased risk for cirrhosis, hepatocellular carcinoma, type-2 diabetes and cardiovascular disease. Lifestyle intervention aiming at weight reduction is the most established treatment. However, changing the dietary composition even without weight loss can also reduce steatosis and improve metabolic alterations as insulin resistance and lipid profile. The Mediterranean diet (MD) pattern has been proposed as appropriate for this goal, and was recommended as the diet of choice for the treatment of NAFLD by the EASL-EASD-EASO Clinical Practice Guidelines. The MD has an established superiority in long term weight reduction over low fat diet, but it improves metabolic status and steatosis even without it.However, the effect on liver inflammation and fibrosis was tested only in few observational studies with positive results. Furthermore, considering the strong association between NAFLD and diabetes and CVD, the MD has a highly established advantage in prevention of these diseases, demonstrated in randomized clinical trials. The individual components of the MD such as olive oil, fish, nuts, whole grains, fruits, and vegetables, have been shown to beneficially effect or negatively correlate with NAFLD, while consumption of components that characterize a Western dietary pattern as soft drinks, fructose, meat and saturated fatty acids have been shown to have detrimental association with NAFLD. In this review we will cover the epidemiological evidence and the plausible molecular mechanisms by which the MD as a whole and each of its components can be of benefit in NAFLD.

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Section: Summary and Practical Implicationsmentioning

confidence: 99%

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Zelber‐Sagi

Salomone²,

Mlynarsky

2017

Liver International

190

150

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show abstract

“…The underlying genetic bases of both NAFLD and CAD have been widely studied, and recenly reviewed by Li et al[90]. The authors have reviewed the literature on gene polymorphisms of the leptin receptor (LEPR), apolipoprotein C3 (APOC3), adiponectin-encoding gene (ADIPOQ), peroxisome proliferator-activated receptors (PPAR), sterol regulatory element-binding proteins (SREBP), microsomal triglyceride transfer protein (MTTP), transmembrane 6 superfamily member 2 (TM6SF2), tumor necrosis factors-alpha (TNF-α) and manganese superoxide dismutase (MnSOD), all of which have been linked to NAFLD and CAD.…”

Section: Nafld and Cvd Geneticsmentioning

confidence: 99%

Nonalcoholic fatty liver disease - A multisystem disease?

Mikolašević

Milić

Wensveen

et al. 2016

WJG

146

150

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of MetS. However, accumulating evidence indicates that the effects of NAFLD extend beyond the liver and are negatively associated with a range of chronic diseases, most notably cardiovascular disease (CVD), diabetes mellitus type 2 (T2DM) and chronic kidney disease (CKD). It is becoming increasingly clear that these diseases are the result of the same underlying pathophysiological processes associated with MetS, such as insulin resistance, chronic systemic inflammation and dyslipidemia. As a result, they have been shown to be independent reciprocal risk factors. In addition, recent data have shown that NAFLD actively contributes to aggravation of the pathophysiology of CVD, T2DM, and CKD, as well as several other pathologies. Thus, NAFLD is a direct cause of many chronic diseases associated with MetS, and better detection and treatment of fatty liver disease is therefore urgently needed. As non-invasive screening methods for liver disease become increasingly available, detection and treatment of NAFLD in patients with MetS should therefore be considered by both (sub-) specialists and primary care physicians.

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“…Patients with NAFLD exhibit a range of non-traditional risk factors of cardiovascular disease, including hyperuricaemia and hypovitaminosis D [ 16 ]. In addition, shared genetic factors exist between NAFLD and coronary artery heart disease, for instance: gene polymorphisms of adiponectin-encoding gene (ADIPOQ), leptin receptor (LEPR), apolipoprotein C3 (APOC3), peroxisome proliferator-activated receptors (PPAR), sterol regulatory element binding proteins (SREBP), transmembrane 6 superfamily member 2 (TM6SF2), microsomal triglyceride transfer protein (MTTP), TNF-α, and manganese superoxide dismutase (MnSOD) [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

The influence of NAFLD on the risk of atherosclerosis and cardiovascular diseases

Wójcik-Cichy

Koślińska-Berkan

Piekarska

2018

ceh

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Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in developed countries and is associated with obesity, dyslipidaemia, diabetes, and metabolic syndrome. Atherosclerosis and cardiovascular diseases are also highly prevalent in this group of patients, due to the presence of shared risk factors. The incidences of coronary artery calcification, hypertension, aortic valve sclerosis, diastolic dysfunction, atherosclerotic plaques, and increased carotid intima-media thickness were more common in patients with NAFLD than in those without. The present paper reviews the medical literature concerning the association between NAFLD and cardiovascular events.

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Gene polymorphisms associated with non-alcoholic fatty liver disease and coronary artery disease: a concise review

Cited by 38 publications

References 94 publications

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

The Mediterranean dietary pattern as the diet of choice for non‐alcoholic fatty liver disease: Evidence and plausible mechanisms

Nonalcoholic fatty liver disease - A multisystem disease?

The influence of NAFLD on the risk of atherosclerosis and cardiovascular diseases

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