Association of total zinc, iron, copper and selenium intakes with depression in the US adults

Li, Zongyao; Wang, Weijing; Xin, Xueling; Song, Xingxing; Zhang, Dongfeng

doi:10.1016/j.jad.2017.12.004

Cited by 123 publications

(96 citation statements)

References 47 publications

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“…Epidemiologic studies have shown that depression is related to genetic and environmental factors, especially dietary factors [6][7][8][9]. For instance, vegetables [10], fruits [10], fish [11], and dietary fiber [12] have been reported to reduce the risk of depression, and some nutrients [13,14] (e.g., magnesium, zinc, iron, copper, and selenium) can also reduce the risk of depression.…”

Section: Introductionmentioning

confidence: 99%

Associations of n-3, n-6 Fatty Acids Intakes and n-6:n-3 Ratio with the Risk of Depressive Symptoms: NHANES 2009–2016

Zhang

Sun

et al. 2020

Nutrients

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Many studies have explored the association between n-3 fatty acids and depression, but research on the associations of n-6 fatty acids and n-6:n-3 ratio with depression is more scarce, and the results are controversial. Therefore, we conducted this cross-sectional study to explore the associations of n-3 and n-6 fatty acid intakes and n-6:n-3 ratio with the risk of depressive symptoms using data from National Health and Nutrition Examination Survey (NHANES) 2009–2016. Dietary data on n-3 and n-6 fatty acids were obtained through two 24-h dietary recall interviews, and were adjusted by energy. Depressive symptoms were measured by PHQ-9 (nine-item Patient Health Questionnaire). We applied logistic regression and restricted cubic spline models to assess the relationships of n-3 and n-6 fatty acids intake and n-6:n-3 ratio with the risk of depressive symptoms. A total of 17,431 individuals over 18 years old were enrolled in this study. In the multivariate-adjusted model 2, compared with the lowest category, the highest odd ratios (ORs) with 95% confidence intervals (CIs) for n-3 fatty acid intake and n-6:n-3 ratio were 0.71 (0.55–0.92) and 1.66 (1.10–2.50), and middle OR (95% CI) for n-6 fatty acid intake was 0.72 (0.56–0.92), respectively. Our study suggests that n-3 and n-6 fatty acids intake were inversely associated with the risk of depressive symptoms, while the n-6:n-3 ratio was positively associated with the risk of depressive symptoms.

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Section: Introductionmentioning

confidence: 99%

Associations of n-3, n-6 Fatty Acids Intakes and n-6:n-3 Ratio with the Risk of Depressive Symptoms: NHANES 2009–2016

Zhang

Sun

et al. 2020

Nutrients

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“…Demirin bu işleyişteki önemli özelliği, beyin parankimasının oksijenlenmesinde görev alması ve dopamin ve serotonin gibi nörotransmitterlerin sentezinde alt rol oynamasıdır. 29 Demirin bu görevini destekler nitelikteki bir başka sonuç ise fiziksel olarak aktif kadınlardaki demir eksikliğinin davranış ve dayanıklılığa etkisini araştıran bir çalışmada öne sürülmüştür. Hafif demir eksikliğinin genç kadınlar arasında hem motivasyonel hem de duygusal işlevi değiştirebileceği gösterilmiştir.…”

Section: Demi̇runclassified

“…[49][50][51] Depresyon hastalarında kandaki bakır seviyelerinin anormal değişimi ve depresyonun bakırla ilişkisi incelendiğinde, bakırın potansiyel bir depresyon belirteci olduğu ve depresyon tanı ve tedavisinde görev alabileceği söylenebilir. 29 Amerikan vatandaşları üzerinde yapılmış bir çalışmada, bakır ve selenyum alımının depresyon ile ilişkili olduğu savunulmuştur. 42 Koreli adölesan kızlar üzerinde yapılmış bir çalışmada ise bakır alımının düşük depresyon riski ile ilişkili olduğu vurgulanmıştır.…”

Section: Bakirunclassified

The Role of Iron, Zinc, Copper and Magnesium in the Prevention and Treatment of Depression

Tuğtepe¹,

Koç²

2020

J Lit Pharm Sci

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“…In addition, the hormone also inhibits the 5-hydroxytryptamine 3 (5-HT3) receptor, which is responsible for the serotonin uptake in the synaptic cleft, thereby reducing the stimulation of the target cell [12]. Antidepressants from the selective serotonin reuptake inhibitor (SSRIs) group have a similar effect.When analyzing the pathophysiology of depression symptoms, we should note the changes in concentrations of bioelements, as they may underlie the mechanisms leading to emotional disorders as well as clinical depression [13][14][15][16]. In suffering patients, magnesium supplementation has been used, as it affects several biochemical pathways in the brain responsible for apathy [17].…”

mentioning

confidence: 99%

“…When analyzing the pathophysiology of depression symptoms, we should note the changes in concentrations of bioelements, as they may underlie the mechanisms leading to emotional disorders as well as clinical depression [13][14][15][16]. In suffering patients, magnesium supplementation has been used, as it affects several biochemical pathways in the brain responsible for apathy [17].…”

mentioning

confidence: 99%

The Relationship between Selected Bioelements and Depressiveness Associated with Testosterone Deficiency Syndrome in Aging Men

et al. 2020

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Background and Objectives: Abnormal concentrations of bioelements (magnesium, manganese, chromium, copper, zinc) have been associated with physical and emotional dysfunctions, including depression. This association, however, has not been analyzed in testosterone deficiency syndrome (TDS) or patients with depressiveness, i.e., when individual symptoms do not form the picture of a full-syndrome depressive disorder. This study aimed to assess the relationship between concentrations of selected bioelements and the incidence of depressive symptoms in men aged 50 years and older with a concurrent testosterone deficiency syndrome. Material and Methods: Blood samples were taken from 314 men; the mean age of the population was 61.36 ± 6.38 years. Spectrophotometric method for biochemical analysis of magnesium (Mg), manganese (Mn), chromium (Cr), copper (Cu), and zinc (Zn) was used. The diagnosis of testosterone deficiency syndrome (TDS) was based on the total testosterone (TT), free testosterone (FT), estradiol (E2), and dehydroepiandrosterone sulfate (DHEAS) levels by ELISA. Each participant completed the Androgen Deficiency in Aging Male (ADAM) questionnaire, as well as the Beck Depression Inventory (BDI-Ia) measuring the severity of depressive symptoms. Results: Emotional disturbances manifested as depressive symptoms were diagnosed in 28.7% of all participants and testosterone deficiency syndrome in 49.3%. In the TDS group, the analysis showed a significant correlation between the level of manganese (R = 0.225, p = 0.005) and chromium (R = 0.185, p = 0.021) with the incidence of depression. Conclusions: The results of our study demonstrated a relationship between manganese and chromium concentrations with the incidence of depression in men aged 50 years and older with a concurrent testosterone deficiency syndrome. This may indicate that there is a correlation between these bioelements, as well as emotional disorders manifested as depressive symptoms in aging men with a diagnosed testosterone deficiency.

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Association of total zinc, iron, copper and selenium intakes with depression in the US adults

Cited by 123 publications

References 47 publications

Associations of n-3, n-6 Fatty Acids Intakes and n-6:n-3 Ratio with the Risk of Depressive Symptoms: NHANES 2009–2016

Associations of n-3, n-6 Fatty Acids Intakes and n-6:n-3 Ratio with the Risk of Depressive Symptoms: NHANES 2009–2016

The Role of Iron, Zinc, Copper and Magnesium in the Prevention and Treatment of Depression

The Relationship between Selected Bioelements and Depressiveness Associated with Testosterone Deficiency Syndrome in Aging Men

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