The Relationship between Selected Bioelements and Depressiveness Associated with Testosterone Deficiency Syndrome in Aging Men

Rotter, Iwona; Wiatrak, Adrian; Rył, Aleksandra; Kotfis, Katarzyna; Ciosek, Żaneta; Sipak-Szmigiel, Olimpia; Szylińska, Aleksandra

doi:10.3390/medicina56030125

Cited by 5 publications

(2 citation statements)

References 45 publications

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“…Erectile dysfunction may have related to the testosterone deficiency syndrome which has also been noted in aging men [36]. In this study on 314 men greater than 60-years-old, 49% had testosterone deficiency syndrome and 29% had depressive symptoms.…”

Section: Sexual Performance Problemsmentioning

confidence: 55%

Late Life Depression: A Narrative Review

2023

Int J Geriatr Gerontol

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The recent literature (last five years) on late life depression is predominantly focused on risk factors/predictors of late life depression along with studies on effects, buffers, and interventions. Late life depression has typically been self-reported or diagnosed starting at age 60. The prevalence rates for late life depression were highly variable in this literature, ranging from a low of 7% in Italy to a high of 37% in Chile, a variability that may relate to the year or type of data collection and/or crosscultural variation. Negative effects have included loneliness, suicidal ideation, cognitive decline, frailty, functional limitations, low heart rate variability, biological aging (short telomere length and white matter lesions) and earlier mortality. Risk factors have included loneliness, aging anxiety, life stressors (marital discord and job strain), physical problems (activities of daily living), physical health (elevated blood pressure), physical weakness (handgrip, frailty, falls and disability) and unhealthy intake (poor diet, excessive alcohol and vitamin D deficiency). Buffers/protective factors have included positive views on aging, resilience, practicing religion, a Mediterranean diet, and remaining active. Interventions have included cognitive training, mindfulness, physical activity and ketamines. Multiple underlying mechanisms have been suggested including dysfunctional connectivity between different networks in the brain. Although the data highlight the severity of late life depression, the recent literature has been based on different measures appearing on self-report surveys that have yielded mixed results across samples. Prevalence of Late Life DepressionFirst, some myths about late life depression in a paper entitled "Depression among older adults: A 2-year update on common myths and misconceptions" are worth summarizing [1]. These authors concluded: 1) depression is not more common in older adults; 2) late life depression is not more often caused by psychological factors; 3) those who experience late life depression respond to psychological interventions as well as younger adults, but not to antidepressants; 4) late life depression follows a more chronic course (i.e. a greater rate of relapse); and 5) late life depression is frequently moderated by comorbidity.

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Section: Sexual Performance Problemsmentioning

confidence: 55%

Late Life Depression: A Narrative Review

2023

Int J Geriatr Gerontol

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“…Similarly, three studies identified an increased prevalence of depression among men with TD compared with those without TD. Using an 11-point reference value of the Beck Depression Inventory (BDI) scale, Rotter et al [19] reported a prevalence of 30.9% vs. 26.4%, and Boeri et al [20] a prevalence of 52.4% vs. 23.8%. In contrast, Jankovska et al used a reference value of 16 on the BDI scale to define depressive symptoms and identified that in the group of patients with depressive symptoms, 31% also had testosterone deficiency, compared to 12% in the group without depressive symptoms [21].…”

Section: Discussionmentioning

confidence: 99%

Testosterone deficiency is associated with clinically relevant depression symptoms

Vartolomei

Tătaru

Cotruș

et al. 2023

Acta Marisiensis - Seria Medica

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Objective: To investigate the association between testosterone deficiency and depressive and/or anxiety symptoms. Methods: A cross-sectional study was conducted at the urology outpatient clinic from Ludus County Hospital. A set of validated questionnaires ((International Prostate Symptoms Score (IPSS), Depression Anxiety and Stress Scale (DASS-21), Zung Self-rating Depression Scale (Zung SDS)) were self-administrated. Inclusion criteria: age > 40 years. Exclusion criteria: any relevant psychiatric, cardiovascular, or cancer comorbidity. Statistical analyzes were performed using the statistical software Statistical Package for Social Sciences (SPSS, version 23, Chicago, IL, USA). Results: From the total of 55 participants included in the study, 23 (41.8%) had testosterone deficiency. Most were from the 60-69 years decade, 23 participants (41.8%), and the mean age was 59.3 (SD 9.03) years. Eleven (20%) patients had depressive symptoms according to the depression subscale, of these, 7 had mild symptoms and 4 according to Zung SDS. Testosterone deficiency was associated with an increased DASS-21 global score, p=0.021, and depression score, p=0.047. Conclusions: Patients with testosterone deficiency are presenting symptoms of depression. Therefore, these patients need a multi-disciplinary approach that should include a psychological evaluation before making a further management decision.

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Negative correlation between metabolic score for insulin resistance index and testosterone in male adults

Li,

2024

Diabetol Metab Syndr

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Background Insulin resistance (IR) is strongly correlated with the decreased deficiency of testosterone levels in males. The metabolic score for insulin resistance (METS-IR) index is regarded as an innovative measure for the assessment on IR. The research aims to explore the correlation between the METS-IR index and the testosterone levels in males. Methods In this study, a cross-sectional design was made through the data obtained from the National Health and Nutrition Examination Survey (NHANES) from 2013 to 2020. Besides, the METS-IR index was derived from serum triglyceride levels, fasting plasma glucose, HDL-C and BMI. Results A total of 2082 participants were included in the final analysis. After controlling for confounding variables, it was found that METS-IR was independently and negatively correlated with testosterone levels (β = −3.88, 95% CI = −4.49, −3.27, P < 0.001). As shown by the generalized smooth curve fitting, METS-IR had a linear correlation with testosterone levels without threshold or saturation effects, which was consistently observed across all subgroups through stratified analysis (all P > 0.05). As revealed by the analysis on the ROC curve, the area under the curve (AUC) for the METS-IR index (0.732, 95% CI = 0.705, 0.760) was significantly larger than that of homeostatic model assessment of insulin resistance (HOMA-IR), TG/HDL ratio, triglyceride-glucose index (TyG) and body mass index (BMI). Conclusion The findings suggest a negative relationship between the METS-IR index and the testosterone levels in male adults. Furthermore, the METS-IR index demonstrates superior predictive ability for testosterone deficiency in comparison to HOMA-IR, TG/HDL ratio, TyG and BMI.

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The Relationship between Selected Bioelements and Depressiveness Associated with Testosterone Deficiency Syndrome in Aging Men

Cited by 5 publications

References 45 publications

Late Life Depression: A Narrative Review

Late Life Depression: A Narrative Review

Testosterone deficiency is associated with clinically relevant depression symptoms

Negative correlation between metabolic score for insulin resistance index and testosterone in male adults

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