Association of TNF-α −308 polymorphism with the outcome of hepatitis B virus infection in Turkey

Baştürk, Bilkay; Karasu, Zeki; Kılıç, Murat; Ulukaya, Sezgin; Boyacioglu, Sedat; Oral, Barbaros

doi:10.1016/j.meegid.2007.09.001

Cited by 31 publications

(28 citation statements)

References 40 publications

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“…Although Basturk et al (2008) found that the frequency of the TNF-A-308 G/G variant in a Turkish population was significantly higher in individuals infected with the HBV than in the healthy controls, this study found no significant differences between the CHB and the SR groups in the distribution or the ORs of the TNF-A-308 variants. This discrepancy may be due to the different control groups used in the studies.…”

Section: Discussioncontrasting

confidence: 91%

“…This discrepancy may be due to the different control groups used in the studies. While Basturk et al (2008) recruited healthy individuals to use for their control group, our group recruited individuals who had spontaneously recovered from hepatitis B as controls.…”

Section: Discussionmentioning

confidence: 99%

“…The base replacement of G to A at site -308 leads to sequence variants in its promoter region. Several studies have reported conflicting results regarding the effect of the TNF-α-308 sequence variants on chronic hepatitis B (CHB) viral infections (Höhler et al, 1998;Du et al, 2006;Basturk et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population

Yu¹,

Sf²,

Xia³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. An association between the sequence variants of cytokine genes and various clinical outcomes in subjects infected with the hepatitis B virus (HBV) has been demonstrated. However, the results are inconsistent and inconclusive. Further studies in other populations and the evaluation of a greater number of individuals may contribute to a better understanding of the influence of the cytokine genetic variants on the evolution of HBV infections. This study was performed to explore the relationships between the sequence variants of TNF- A-308, IFNAR1-17470, and IL-10-592 and the susceptibility to chronic hepatitis B (CHB) in a Chinese population. A total of 160 patients with CHB and 124 individuals who had spontaneously recovered (SR) from hepatitis B were enrolled in the present study. The variants at TNF-A-308, IFNAR1-17470, and IL-10-592 were determined by PCR-restriction fragment length polymorphism analysis and were confirmed by bidirectional DNA sequencing. Significant differences were found between the CHB and the SR groups in the frequency and distribution of the genotypes of both IFNAR1-17470 and IL-10-592 genes. In comparison with the CHB patients with the IFNAR1-17470 G/G variant, the odds ratio (OR) of the CHB patients with the IFNAR1-17470 C/C variant developing chronic hepatitis was 2.06 (95%CI = 1.03-4.14). In addition, the OR of the patients with CHB having the IL-10-592 C/C variant developing chronic hepatitis was 2.77 (95%CI = 1.13-4.57) when compared with that of the patients with the IL-10-592 A/A variant. In conclusion, sequence variants of both the IFNAR1-17470 and IL-10-592 genes were correlated with susceptibility to CHB.

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Section: Discussioncontrasting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

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Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population

Yu¹,

Sf²,

Xia³

et al. 2014

Genet. Mol. Res.

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“…In summary, our results highlight differences in cytokine levels in the serum that can distinguishing OHBinfected patients from patients that resolved HBV infection, and these results are consistent with a cytokine involvement during the immune response to viral infection (Chen et al 2005, Falasca et al 2006, Basturk et al 2008, Chan et al 2008, Larrubia et al 2009, Macedo et al 2010. Large-scale studies that involve distinct ethnic groups infected with different HBV genotypes are needed to determine how genetics may influence OHB development.…”

Section: Discussionsupporting

confidence: 82%

Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

Fierro¹,

Román²,

Realpe³

et al. 2011

Mem. Inst. Oswaldo Cruz

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A high prevalence of occult hepatitis B (OHB) genotype H infections has been observed in the native Mexican Nahua population. In addition, a low incidence of hepatitis B virus (HBV)-associated hepatocellular carcinoma has been described in Mexico. The immune response to infection among OHB-infected patients has been poorly evaluated in vivo. Therefore, we assessed the expression profiles of 23 cytokines in OHB genotype H-infected Nahua patients. A total of 41 sera samples from natives of the Nahua community were retrospectively analysed. Based on their HBV antibody profiles, patients were stratified into two groups: OHB patients (n = 21) and patients that had recovered from HBV infection (n = 20). Herein, we report distinctive cytokines profiles in OHB-infected individuals. Compared to healthy controls (n = 20) and patients who resolved HBV infection, OHB-infected patients displayed an increase in interleukin (IL)-2 secretion in addition to a characteristic inflammation profile (decrease in IL-8 and tumour necrosis factor-alpha levels and increased levels of tumour growth factor-beta). IL-15 and interferon-gamma levels were reduced in OHB-infected individuals when compared to those patients who resolved HBV infection. In contrast, OHB patients showed an increase in monocyte chemoattractant protein (MCP)-1 and MCP-2 compared to healthy controls and patients who resolved HBV infection. These findings suggest that cytokine expression can influence the severity of OHB disease and could lead to new investigation into the treatment of liver and other infectious diseases

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“…So far, researches have found two strong susceptibility loci for HBV infection including 8p12 [3] and 1p36.22 [4], both of which were unraveled by the genome-wide association study. Meanwhile, several other genes relevant to HLA-DP [5] HLA-DRB1*13 and TNF-α gene [6], cytotoxic T-lymphocyte antigen [7], IL-28B [8], IFN-γ [9] polymorphisms are related to the development of chronic HBV infection [6,[10][11][12]. It has been well documented that disturbed regulatory CD4 T helper (Th) cells account much for the pathogenesis of HBV infection.…”

Section: Introductionmentioning

confidence: 99%

Association study between polymorphism of interleukin 12B 1188A/C and hepatitis B virus infection in a Chinese Han population

Wang¹,

Yin²,

Cao³

et al. 2013

cejoi

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Association of TNF-α −308 polymorphism with the outcome of hepatitis B virus infection in Turkey

Cited by 31 publications

References 40 publications

Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population

Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population

Multiple cytokine expression profiles reveal immune-based differences in occult hepatitis B genotype H-infected Mexican Nahua patients

Association study between polymorphism of interleukin 12B 1188A/C and hepatitis B virus infection in a Chinese Han population

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