Association of the IFNAR1-17470 and IL-10-592 cytokine variants with susceptibility to chronic hepatitis B viral infections in a Chinese population

Abstract

ABSTRACT. An association between the sequence variants of cytokine genes and various clinical outcomes in subjects infected with the hepatitis B virus (HBV) has been demonstrated. However, the results are inconsistent and inconclusive. Further studies in other populations and the evaluation of a greater number of individuals may contribute to a better understanding of the influence of the cytokine genetic variants on the evolution of HBV infections. This study was performed to explore the relationships between the sequence variants of TNF- A-308, IFNAR1-17470, and IL-10-592 and the susceptibility to chronic hepatitis B (CHB) in a Chinese population. A total of 160 patients with CHB and 124 individuals who had spontaneously recovered (SR) from hepatitis B were enrolled in the present study. The variants at TNF-A-308, IFNAR1-17470, and IL-10-592 were determined by PCR-restriction fragment length polymorphism analysis and were confirmed by bidirectional DNA sequencing. Significant differences were found between the CHB and the SR groups in the frequency and distribution of the genotypes of both IFNAR1-17470 and IL-10-592 genes. In comparison with the CHB patients with the IFNAR1-17470 G/G variant, the odds ratio (OR) of the CHB patients with the IFNAR1-17470 C/C variant developing chronic hepatitis was 2.06 (95%CI = 1.03-4.14). In addition, the OR of the patients with CHB having the IL-10-592 C/C variant developing chronic hepatitis was 2.77 (95%CI = 1.13-4.57) when compared with that of the patients with the IL-10-592 A/A variant. In conclusion, sequence variants of both the IFNAR1-17470 and IL-10-592 genes were correlated with susceptibility to CHB.

Association between cytokine gene polymorphisms and outcome of hepatitis B virus infection in southern Brazil

“…In this study, the genotypic profile AA + CA at position ‐592 in the promoter of the IL10 gene was found to be more frequent in the clearance group than among the chronically HBV infected individuals. This seemed to corroborate previous studies performed in China showing an increased frequency of the AA genotype in subjects with viral clearance [Wang et al, ] and an association of the GG genotype to chronicity [Xiang et al, ]. However, the difference of genotype frequencies observed here was not statistically significant, and divergent findings have also been reported [Cheong et al, ; Sofian et al, ].…”

“…The outcome of infection is thought to depend on viral, environmental and host genetic factors. Due to the key role of cytokine expression levels in the immunoregulatory response against HBV infection, a number of SNPs located in IL2, IL4, IL6, IL10, IL12B, IL16, IL17, IL18, IL21, IL23R, IFNγ, and TNF‐α genes have been investigated in order to evaluate their importance on the balance between host immunity and viral survival strategies [Wang et al, , ; Gao et al, ; Lu et al, ; Romani et al, ; Tunçbilek, ; Xiang et al, ; Zhang et al, ; Ferreira et al, ; Ren et al, ; Sghaier et al, ; Wu et al, ; Yao et al, ].…”