Association study between polymorphism of interleukin 12B 1188A/C and hepatitis B virus infection in a Chinese Han population

Wang, Zusen; Yin, Congcong; Cao, Jingyu; Wang, Xue Qin; Ren, Wei; Huang, Feilong; Shi, Chengyu; Sun, Dawei; Wu, Liqun; Liu, Shiguo

doi:10.5114/ceji.2013.39763

Cited by 1 publication

(1 citation statement)

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“…However, these allele frequencies did not show any statistical significance. A study has also reported similar results as their study reported no significant association between the allele frequencies and incidences of HBV infections in the Han Chinese population [59].…”

Section: Discussionsupporting

confidence: 65%

Impact of IL-12B Genetic Variants on Antiviral Treatment Response among Hepatitis B Patients in Pakistan

Badshah,

Shabbir,

Zafar

et al. 2023

Livers

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HBV is a continuous major global health concern. Genetic factors of hosts are known to play a role in HBV infection outcomes. This study aimed to reveal the association of IL-12b 3′ UTR variant rs3212227 in HBV patients. Genotyping was performed using ARMS-PCR to detect IL-12b rs3212227 polymorphism. The patients were categorized into groups based on their response to the antiviral therapy. Group I: non-sustained virological response (NSR); Group II: sustained virological responders (SVR); and Group III: HBV-positive fresh cases. ALT levels were measured to evaluate liver function, and viral load was determined to evaluate viral infectivity among the study groups. The variant genotype CC was found to be significantly associated with the non-sustained virological response to the antiviral therapy (with a p-value of 0.0117; OR = 2.914; RR = 1.556). It was also determined that the genotype CC was the most prevalent genotype among both genders in the NSR group. Viral load was found to be 6-fold higher in Group III compared to Group I and Group II. The results suggest that genotype CC is the most prevalent genotype in the NSR groups, and it is associated with a poor response to antiviral therapy in Pakistani patients with HBV infection.

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Section: Discussionsupporting

confidence: 65%