Association of the gut microbiota and fecal short‐chain fatty acids with skeletal muscle mass and strength in children

Chen, Fengyan; Li, Qing; Chen, Ying; Wei, Yuanhuan; Liang, Jingjing; Song, Yanyan; Shi, Linna; Wang, Jue; Mao, Limei; Zhang, Bo; Zhang, Zheqing

doi:10.1096/fj.202002697rrr

Cited by 14 publications

(24 citation statements)

References 53 publications

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“…It is well known that SCFAs can not only provide energy for the intestinal epithelial cells but also firmly maintain the morphology and function of the intestine ( 37 , 38 ). Moreover, SCFAs have also been confirmed to promote glucose intake and metabolism in skeletal muscle, and butyrate can improve the energy metabolism efficiency of muscle fibers ( 39 , 40 ). Based on the functions of the above bacterial families (fiber fermentation, inflammation mitigation, stress adaptation, and promotion of SCFAs on energy uptake and metabolism in skeletal muscle), it is speculated that these different bacterial families play a positive role in the performance of Thoroughbred horses.…”

Section: Discussionmentioning

confidence: 99%

Variations in the fecal microbiota and their functions of Thoroughbred, Mongolian, and Hybrid horses

Luo

et al. 2022

Front. Vet. Sci.

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The horse gut is colonized by a rich and complex microbial community that has important roles in horse physiology, metabolism, nutrition, and immune functions. Fewer across-breed variations in horse gut microbial diversity have been illustrated. In this article, the gut microbiota of Thoroughbred, Mongolian, and Hybrid horses [first filial generation (F1) of Mongolian (maternal) and Thoroughbred (paternal)] were studied by second-generation high-throughput sequencing technology. Differences in gut microbiota composition and function between breeds were determined using diversity and functional prediction analysis. The alpha diversity analysis showed that Thoroughbred horses had a more abundant and diverse gut microbiota, while the diversity of gut microbiota in Hybrid horses was intermediate between Thoroughbred and Mongolian horses. Subsequent cluster analysis showed that Hybrid horses have a microbiota composition more similar to Mongolian horses. LEfSe analysis revealed that the bacterial biomarkers for Thoroughbred horses at the family level were Prevotellaceae, Rikenellaceae, Fibrobacteraceae, p_251_o5, Lactobacillaceae, and uncultured_bacterium_o_WCHB1_41; the bacterial biomarker for Mongolian horses was Planococcaceae; and the bacterial biomarkers for Hybrid horses were Moraxellaceae, Enterobacteriaceae, and Ruminococcaceae. The functional prediction results indicated that the metabolic pathways differ significantly between the breeds. Regarding metabolism, the Hybrid horses had the lowest proportion of the carbohydrate metabolic pathways, while the energy metabolic pathway had the highest proportion. The abundance ratios of the remaining eight metabolic pathways in Hybrid horses were between Thoroughbred and Mongolian horses. In conclusion, the results of this study showed an association between horse breeds and gut microbiota.

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Section: Discussionmentioning

confidence: 99%

Variations in the fecal microbiota and their functions of Thoroughbred, Mongolian, and Hybrid horses

Luo

et al. 2022

Front. Vet. Sci.

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“…A previous study among healthy Chinese children reported that relationship of gut microbiome between muscle parameters was mediated by body fat content. 10 However, the cross‐sectional design of this study could not determine the temporal directionality of the association among fat mass, skeletal muscle mass and gut microbiota. Without validation of the temporal ordering of variables, the magnitude of the bias may be introduced by mediation analysis or conditioning on a collider, although we observed significant negative correlations between fat mass and SMI in both sexes.…”

Section: Discussionmentioning

confidence: 90%

“… 9 Recently, a few studies on the association between gut microbiota and muscle parameters have been reported. 10 , 11 , 12 To the best of our knowledge, however, no large population‐based study, including young‐ and middle‐aged individuals, has investigated the association of gut microbiota with skeletal muscle mass. In addition, various previous studies have shown a strong association between sex and loss of muscle mass on human health, 9 and sex specificity is known to influence the composition of the gut microbiome.…”

Section: Introductionmentioning

confidence: 99%

Sex‐specific associations between gut microbiota and skeletal muscle mass in a population‐based study

Park

Lee

Kim

et al. 2022

J cachexia sarcopenia muscle

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Background A gut-muscle axis through which the microbiome influences skeletal muscle has been hypothesized. However, sex-specific association between the characteristics of gut microbiota and skeletal muscle mass has not yet been reported. Herein, we performed sex-specific analyses of faecal microbiota composition for the skeletal muscle mass in a population-based cohort. Methods We collected faecal samples of 1052 middle-aged participants (621 men and 431 women) who attended health screenings, and we analysed the intestinal microbiota using 16S rRNA gene sequencing. Relative muscle mass was calculated using a bioelectrical impedance analysis and presented as the skeletal muscle mass index [SMI (%) = total appendicular muscle mass (kg)/weight (kg) × 100]. We categorized the subjects into four groups by the quartile of the SMI. Association tests between gut microbiota and SMI were conducted according to the microbial diversity, taxonomic profiling and functional inference in a sex-stratified manner. ResultsThe mean age and SMI of the total participants were 44.8 years (standard deviation [SD], 8.2) and 41.4% (SD, 3.9), respectively. After adjustments for possible covariates such as age, body mass index and regular physical activity, the highest quartile (Q4) group of SMI had higher alpha diversity than the lowest quartile (Q1) group in male participants (coefficient = 10.79, P < 0.05, linear regression model), whereas there was no difference in diversity among SMI groups in females. At the species level, Haemophilus parainfluenzae (coefficient = 1.910) and Roseburia faecis (coefficient = 1.536) were more abundant in the highest SMI (Q4) group than in the lowest SMI (Q1) group in males. However, no significant taxon was observed along the SMI groups in females. The gut microbiota of the lowest SMI group (Q1) was enriched with genes involved in biosynthesis of amino acids and energy generation compared with that of the highest SMI group (Q4) in both sexes, although the significance of the inferred pathways was weak (P < 0.05 but the false discovery rate q > 0.05). Conclusions In this large sample of middle-aged individuals, this study highlights fundamental sex-specific differences in the microbial diversity, composition and metabolic pathways inferred from gut microbiota according to SMI. The gut microbiota may provide novel insights into the potential mechanisms underlying the sex dependence of skeletal muscle mass.

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“…Skeletal muscle oxidative metabolism, glucose uptake, and insulin sensitivity appear to be enhanced by SCFA administration [ 53 ]. SCFAs are associated with skeletal muscle mass and strength in pediatric populations [ 54 , 55 ]. Individuals with lower concentration of butyric acid had lower handgrip strength [ 56 ].…”

Section: Discussionmentioning

confidence: 99%

Puerarin improves skeletal muscle strength by regulating gut microbiota in young adult rats

Yang

Gao

Qin

et al. 2022

Journal of Orthopaedic Translation

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Association of the gut microbiota and fecal short‐chain fatty acids with skeletal muscle mass and strength in children

Abstract: chain fatty acids; TSM, total body lean soft tissue mass; TSM/TBF, the ratio of total body lean soft tissue mass to total body fat mass; TSMR, the ratio of total body lean soft tissue mass to weight; VA, valeric acid.

Cited by 14 publications

References 53 publications

Variations in the fecal microbiota and their functions of Thoroughbred, Mongolian, and Hybrid horses

Variations in the fecal microbiota and their functions of Thoroughbred, Mongolian, and Hybrid horses

Sex‐specific associations between gut microbiota and skeletal muscle mass in a population‐based study

Puerarin improves skeletal muscle strength by regulating gut microbiota in young adult rats

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