Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population

Fernandes, D C R O; Santos, Ney Pereira Carneiro dos; Moraes, Milene Raiol de; Braga, Ana Cristina Oliveira; Silva, Cleonardo Augusto; Ribeiro-dos-Santos, Ândrea; Santos, Sidney Emanuel Batista dos

doi:10.1016/j.ijid.2014.04.011

Cited by 13 publications

(15 citation statements)

References 39 publications

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“…The frequency of the polymorphic allele previously determined for individuals in the city of Belé m who were receiving treatment for tuberculosis (0.30) is similar to the frequency found in the present study (0.36). 33 Knowing the frequency distribution of the allele among different ethnic groups will improve our knowledge, evaluation, and understanding of the consequences of genetic variation, especially with regard to the influence of the response to treatment for infectious diseases.…”

Section: Discussionmentioning

confidence: 99%

The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon

Queiroz

Laurentino

Amoras

et al. 2017

International Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon

Queiroz

Laurentino

Amoras

et al. 2017

International Journal of Infectious Diseases

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“…In fact, two previous studies reported a subtle increase of EFV plasma concentration in African and African-American patients following EFV-rifampicin treatment (Gengiah et al, 2012;Luetkemeyer et al, 2013). Co-administration of first-line TB drugs are associated with drug induced hepatotoxicity (Xiang et al, 2014;Yimer et al, 2011;Fernandes et al, 2015) Rifampicin (RMP) and Isoniazid (INH) are widely used combination regimens and were shown to associate with hepatotoxicity in TB patients with CYP2B6 c.516TT genotype (Fernandes et al, 2015). In this context, our findings suggest that 40% (8/20) of participants (CYP2B6 c.516TT) with HIV-1 + TB co-infection in this study may likely develop drug induced hepatotoxicity if RMP and INH are administered together.…”

Section: Discussionmentioning

confidence: 99%

“…CYP2B6 is also involved in the metabolism of RMP and INH (Yimer et al, 2011). The CYP2B6 c.516G>T polymorphism was shown to modulate the TB therapeutic response (Fernandes et al, 2015). The CYP2B6 c.516G>T has been associated with an increased plasma exposure to EFV (Cortes et al, 2013;Sinxadi et al, 2015;Swart et al, 2013) and increased risk of toxicity in the CNS (Aurpibul et al, 2012;Martin et al, 2014;Sinxadi et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection

Peko

Gueye

Vouvoungui

et al. 2019

International Journal of Infectious Diseases

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A total of 418 patients with HIV-1 mono-infection, HIV-1 and Tuberculosis coinfection and symptomatic P. falciparum malaria were genotyped for the CYP2B6 c.516G>T SNP using Restriction Fragment Length Polymorphism (RFLP). The allele frequencies and genotype distributions were determined. Results: The CYP2B6 c.516G>T was successfully analysed in 69% (288/418) of the study participants. Among the investigated individuals, the distribution of the major allele CYP2B6*G was 45% and the minor CYP2B6*T allele was 55%. Significant differences in genotype distribution were also observed among the studied individuals. The CYP2B6*GG (rapid metabolizer) genotype was observed in 17% (49/288) followed by CYP2B6*GT (intermediate metabolizer) 55% (159/288) and CYP2B6*TT (poor metabolizers) 28% (80/ 288). Conclusion: This study contributes to increasing understanding on population pharmacogenetics and may help policy makers regulate treatment guidelines in the Congolese population with a high burden of HIV, Malaria and TB.

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“…P4HB, a disulfate enzyme catalyzation, increased the Th-2 cell migration. In addition, the active compounds not only interacted with protein-related immunity but also another protein like CYP2B6, a cytochrome 450 enzyme, which could be an indicator for tuberculosis therapy [25].…”

Section: Interaction Between Active Compounds Of Indonesian Medicinalmentioning

confidence: 99%

Bioinorganic Chemistry and Computational Study of Herbal Medicine to Treatment of Tuberculosis

Widyarti¹,

Kamaruddin²,

Aristyani³

et al. 2020

Medicinal Plants - Use in Prevention and Treatment of Diseases

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Tuberculosis (TB) is one of the leading infectious diseases in the world. The disease is commonly caused by Mycobacterium tuberculosis (Mtb) bacteria which are capable of rapidly spreading through droplet transmission. In developing countries, poverty and malnutrition cause immunodeficiency which is considered as the main risk factor for the incidence of TB. Treatment of TB has been proven to be difficult because treatment options are very limited and found to be expensive specifically in developing countries. Moreover, the existence of extensively drug-resistant TB phenomena is frequently happening in these countries because of mishandling treatments used for this disease. In Indonesia, the traditional herbal medicine, namely, jamu, has been utilized since a long time ago to treat diseases including TB. The present study by using computational methods found that there are many active compounds that can bound and influence proteins responsible for TB pathogenesis. Besides, these compounds have the potency to modulate the host immune system. The current chapter discussed the possible interaction of the antioxidant compounds with the chelating potential to form a complex with transitional metal as the central atom. In the perspective of bioinorganic chemistry, this complex has a scavenging activity which is expected to have a role in overcoming energy management of the host cell during infection pathogenesis. It is important to involve bioinorganic chemistry in energy management during infection, correlated with impairing of niacin metabolism of the host cell in which the host cell mitochondria cannot competitively gain free radicals during infection. This phenomenon is the main reason to propose herbal medicine as a source of niacin and provide a proper environment for gastrointestinal commensal microbiota to treat and govern protection from TB infection.

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Association of the CYP2B6 gene with anti-tuberculosis drug-induced hepatotoxicity in a Brazilian Amazon population

Abstract: The G516T polymorphism in the CYP2B6 gene is a key predictor of the therapeutic response to treatment in TB patients.

Cited by 13 publications

References 39 publications

The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon

The CYP2B6 G516T polymorphism influences CD4 + T-cell counts in HIV-positive patients receiving antiretroviral therapy in an ethnically diverse region of the Amazon

Cytochrome P450 CYP2B6*6 distribution among Congolese individuals with HIV, Tuberculosis and Malaria infection

Bioinorganic Chemistry and Computational Study of Herbal Medicine to Treatment of Tuberculosis

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