Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

Hayakawa, Tetsuo; Takamura, Toshinari; Abe, Toshio; Kaneko, Shuichi

doi:10.1016/j.metabol.2006.08.020

Cited by 46 publications

(29 citation statements)

References 36 publications

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“…In this study, single locus analyses did not show significant main effects of GNB3 rs5443 (in either genotypic test or odds ratio analysis) on the risk of obesity or overweight in the subjects. Our results were in agreement with those of several other studies (Andersen et al 2006;Hayakawa et al 2007;Suwazono et al 2004). A previous study by Andersen et al (2006) suggested that there is no major involvement of the GNB3 rs5443 polymorphism in obesity in white Danish subjects.…”

Section: Discussionsupporting

confidence: 94%

“…We assumed that this may be partly owing to the differences in the T allele frequency of the GNB3 rs5443 SNP between the present Taiwanese population (56.6 %) and the Japanese study sample by Ishikawa et al (48.7 %). On the contrary, two other Japanese studies by Hayakawa et al (2007) and Suwazono et al (2006) reported no evidence of association between GNB3 rs5443 and total cholesterol levels in the subject with general health examinations. Hayakawa et al (2007) also found that GNB3 rs5443 was not associated with triglyceride.…”

Section: Discussionmentioning

confidence: 70%

“…On the contrary, two other Japanese studies by Hayakawa et al (2007) and Suwazono et al (2006) reported no evidence of association between GNB3 rs5443 and total cholesterol levels in the subject with general health examinations. Hayakawa et al (2007) also found that GNB3 rs5443 was not associated with triglyceride. Possible explanations for the discrepancies in these studies may be the use of insufficient sample sizes, varied phenotype assessment, differences in ethnicity, different study designs, and a lack of adjustment for confounding effects (Andersen et al 2006).…”

Section: Discussionmentioning

confidence: 70%

“…A previous study by Andersen et al (2006) suggested that there is no major involvement of the GNB3 rs5443 polymorphism in obesity in white Danish subjects. Hayakawa et al (2007) also demonstrated that the GNB3 rs5443 polymorphism is unlikely to influence obesity in Japanese subjects who underwent general health examinations. Furthermore, Suwazono et al (2004) reported a lack of association between GNB3 rs5443 and overweight in Japanese workers with general health examinations.…”

Section: Discussionmentioning

confidence: 87%

“…The T allele of GNB3 rs5443 SNP has been reported to predispose to obesity in German (Brand et al 2003;Siffert et al 1999;Stefan et al 2004), Chinese (Siffert et al 1999), and South African (Siffert et al 1999) populations. On the contrary, this association with obesity has not been replicated in white Danish subjects (Andersen et al 2006) and in a Japanese study (Hayakawa et al 2007). In addition, data from a study support the notion that there was statistically significant association of this SNP with total cholesterol levels in a Japanese population (indicating higher in subjects with the T allele) (Ishikawa et al 2000), even though there are some conflicting results in another Japanese study showing no association with cholesterol (Suwazono et al 2006).…”

Section: Introductionmentioning

confidence: 91%

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Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population

et al. 2012

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The relationship between obesity and a single nucleotide polymorphism (SNP), rs5443 (C825T), in the guanine nucleotide binding protein beta polypeptide 3 (GNB3) gene is currently inconsistent. In this study, we aimed to reassess whether the GNB3 rs5443 SNP could influence obesity and obesity-related metabolic traits in a Taiwanese population. A total of 983 Taiwanese subjects with general health examinations were genotyped. Based on the criteria defined by the Department of Health in Taiwan, the terms ''overweight'' and ''obesity'' are defined as 24 2 BMI \ 27 and BMI 3 27, respectively. Compared to the carrier of the combined CT ? TT genotypes of the GNB3 rs5443 polymorphism, triglyceride was significantly higher for the carrier of CC genotype in the complete sample population (128.2 ± 93.2 vs. 114.3 ± 79.1 mg/dl; P = 0.041). In addition, the carriers of CC variant had a higher total cholesterol than those with the combined CT ? TT variants (194.5 ± 36.8 vs. 187.9 ± 33.0 mg/dl; P = 0.019) in the complete sample population. In the normal controls, both triglyceride (P = 0.018) and total cholesterol (P = 0.011) were also significantly higher in the CC homozygotes than in the combined CT ? TT genotypes. However, the GNB3 rs5443 SNP did not exhibit any significant association with obesity or overweight among the subjects. Our study indicates that the CC genotype of the GNB3 rs5443 SNP may predict higher obesity-related metabolic traits such as triglyceride and total cholesterol in non-obese Taiwanese subjects (but not in obese subjects).

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 87%

Section: Introductionmentioning

confidence: 91%

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Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population

et al. 2012

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Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Song

Huang

Zhou

et al. 2021

Intl J Gynecology & Obste

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Background The relationship between the C825T polymorphism of GNB3 (encoding G‐protein β3 subunit) and pre‐eclampsia risk is unclear. Objective To systematically explore the association between GNB3 C825T and pre‐eclampsia. Search strategy PubMed, EMBASE, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI) databases were searched to September 1, 2020, using keywords including “GNB3 C825T” and “pre‐eclampsia”. Selection criteria Case–control and cohort studies investigating the relationship between GNB3 C825T polymorphism and pre‐eclampsia were included. Data collection and analysis Two reviewers collected the data independently and calculate odds ratios (ORs) with 95% confidence intervals (CIs). Main results The meta‐analysis involved eight studies from seven publications, including 2071 cases and 3419 controls. Overall analysis showed that GNB3 C825T was associated with increased pre‐eclampsia risk in the recessive model (OR, 1.21; 95% CI, 1.01–1.44; P = 0.04). Subgroup analysis stratified by Hardy–Weinberg equilibrium revealed a relationship between GNB3 C825T and increased risk of pre‐eclampsia in the allelic (OR, 1.66; 95% CI, 1.34–2.05; P < 0.001), homozygous (OR, 2.12, 95% CI, 1.04–4.32; P = 0.04), dominant (OR, 1.91; 95% CI, 1.18–3.11; P = 0.009), and recessive (OR, 1.70; 95% CI, 1.03–2.81; P = 0.04) models. Conclusions Maternal GNB3 C825T polymorphism seems to be a risk factor for pre‐eclampsia.

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Association between the G-protein β3 subunit C825T polymorphism with essential hypertension: a meta-analysis in Han Chinese population

Guo

Wang

2012

Mol Biol Rep

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We aimed to evaluate the contribution of the G-protein β3 subunit C825T (GNB3-C825T) polymorphism to essential hypertension (EH) in Han Chinese population by performing meta-analysis. A meta-analysis was performed in 12 case-control genetic association studies including 3,020 hypertension patients and 2,790 controls from MEDLINE (PubMed) and the China National Knowledge Infrastructure platforms. The STATA 10.0 software was used in analysis. Overall, there was no significant association between the GNB3-C825T polymorphism and EH in neither additive [TT vs. CC: OR (95 % CI) = 1.11 (0.74-1.69), P = 0.61; TC vs. CC: OR (95 % CI) = 1.08 (0.89-1.31), P = 0.42], nor dominant [TT + TC vs. CC: OR (95 % CI) = 1.11 (0.86-1.42), P = 0.43] and nor recessive [TT vs. TC + CC: OR (95 % CI) = 1.04 (0.75-1.44), P = 0.81] genetic models. Although further subgroup analysis found statistically significant results [T vs. C: OR (95 % CI) = 1.50 (1.05-2.15), P = 0.03] in the southern population, but after exclusion one particular study, the significant association was disappeared. No significant result was found in the northern Han Chinese population. There was no significant association identified between GNB3-C825T polymorphism and EH in Han Chinese population. Further larger sample and well-designed studies are needed to assess the genetic association particularly in the southern Han Chinese population.

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Association of the C825T polymorphism of the G-protein β3 subunit gene with hypertension, obesity, hyperlipidemia, insulin resistance, diabetes, diabetic complications, and diabetic therapies among Japanese

Cited by 46 publications

References 36 publications

Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population

Association of the C825T polymorphism in the GNB3 gene with obesity and metabolic phenotypes in a Taiwanese population

Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Association between the G-protein β3 subunit C825T polymorphism with essential hypertension: a meta-analysis in Han Chinese population

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