Meta‐analysis of the genetic association between maternal GNB3 C825T polymorphism and risk of pre‐eclampsia

Abstract

Background The relationship between the C825T polymorphism of GNB3 (encoding G‐protein β3 subunit) and pre‐eclampsia risk is unclear. Objective To systematically explore the association between GNB3 C825T and pre‐eclampsia. Search strategy PubMed, EMBASE, Google Scholar, and Chinese National Knowledge Infrastructure (CNKI) databases were searched to September 1, 2020, using keywords including “GNB3 C825T” and “pre‐eclampsia”. Selection criteria Case–control and cohort studies investigating the relationship between GNB3 C825T polymorphism and pre‐eclampsia were included. Data collection and analysis Two reviewers collected the data independently and calculate odds ratios (ORs) with 95% confidence intervals (CIs). Main results The meta‐analysis involved eight studies from seven publications, including 2071 cases and 3419 controls. Overall analysis showed that GNB3 C825T was associated with increased pre‐eclampsia risk in the recessive model (OR, 1.21; 95% CI, 1.01–1.44; P = 0.04). Subgroup analysis stratified by Hardy–Weinberg equilibrium revealed a relationship between GNB3 C825T and increased risk of pre‐eclampsia in the allelic (OR, 1.66; 95% CI, 1.34–2.05; P < 0.001), homozygous (OR, 2.12, 95% CI, 1.04–4.32; P = 0.04), dominant (OR, 1.91; 95% CI, 1.18–3.11; P = 0.009), and recessive (OR, 1.70; 95% CI, 1.03–2.81; P = 0.04) models. Conclusions Maternal GNB3 C825T polymorphism seems to be a risk factor for pre‐eclampsia.