Association of testosterone and BDNF serum levels with craving during alcohol withdrawal

Evidence of a Relationship Between Plasma Leptin, Not Nesfatin-1, and Craving in Male Alcohol-Dependent Patients After Abstinence

“…Another study found that the level of BDNF in the seventh day of withdrawal was lower than that of alcohol dependent patients before abstinence (41). Recently, a significant association of BDNF with alcohol craving measured by the Obsessive and Compulsive Drinking Scale (OCDS) was been observed (42). In consonance with these data, the levels of BDNF in the AUD group were lower than that in control group in the present study.…”

Cognitive Functions and Impact of Plasma BDNF in Chronic Heroin Users

“…Therefore, it is likely that increased BDNF expression occurs as a compensatory response to neuronal insult. 25 Our study replicates the results of Heberlein et al, 38 who found BDNF serum levels were significantly increased in the opiate-dependent patients, as compared with healthy controls. Add on BDNF serum levels were significantly associated with craving for heroin, which contributes in dependence syndrome.…”

Brain-derived neurotrophic factor and glutathione peroxidase as state biomarkers in alcohol use disorder patients undergoing detoxification

“…[ 19 ] The variation of the BDNF gene, baseline serum r-GT and relapse count in AUD were related to the alteration of BDNF after treatment. [ 49 ] AUD patients with liver and pancreas disease have even lower BDNF levels [ 50 ] while others claimed no difference, [ 4 ] the relationship between alcohol use and BDNF remains inconclusive. In previous study, BDNF levels were increased in heroin-dependent patients who received methadone maintenance treatment.…”

“…The etiology of AUD has been attributed to genetic abnormality, autoimmune regulation or even heredity. [ 1 , 2 ] Oxidative stress, [ 3 ] brain-derived neurotrophic factor (BDNF) [ 4 ] and brain apoptosis [ 5 ] also play roles in the cause of AUD.…”