Evidence of a Relationship Between Plasma Leptin, Not Nesfatin-1, and Craving in Male Alcohol-Dependent Patients After Abstinence

Xu, Yayun; Ge, Jin‐Fang; Liang, Jun; Pang, Liangjun; Gao, Wenfan; Cao, Yin; Shan, Feng; Yang, Liu; Yan, Chun-Yu; Xia, Qingrong

doi:10.3389/fendo.2020.00159

Cited by 10 publications

(10 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Furthermore, individuals with AUD struggle with craving during abstinence, and some previous reports showed a positive association between craving and TNF-α and IL-6 levels in peripheral blood during alcohol withdrawal ( 81 ). A recent study in AUD individuals at 1 month of abstinence investigated the link between inflammatory biomarker expression and craving in the AUD population ( 82 ). They observed a significant increase in the plasma levels of IL-6, CRP, and TNF-α in AUD patients after 1 month of abstinence.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

et al. 2022

View full text Add to dashboard Cite

Chronic exposure to addictive drugs in substance use disorders and stressors in mood disorders render the brain more vulnerable to inflammation. Inflammation in the brain, or neuroinflammation, is characterized by gliosis, microglial activation, and sustained release of cytokines, chemokines, and pro-inflammatory factors compromising the permeability of the blood-brain barrier. There is increased curiosity in understanding how substance misuse and/or repeated stress exposure affect inflammation and contribute to abnormal neuronal activity, altered neuroplasticity, and impaired cognitive control, which eventually promote compulsive drug-use behaviors and worsen mood disorders. This review will emphasize human imaging studies to explore the link between brain function and peripheral markers of inflammation in substance use disorders and mood disorders.

show abstract

Section: Introductionmentioning

confidence: 99%

“…They observed a significant increase in the plasma levels of IL-6, CRP, and TNF-α in AUD patients after 1 month of abstinence. Based on their results, brain-derived neurotrophic factor (BDNF) and inflammatory cytokines were proposed as potential biomarkers for craving severity in post-abstinent AUD ( 82 ).…”

Section: Introductionmentioning

confidence: 99%

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The PACS, one of the most widely used tools to measure the craving for alcohol, has demonstrated reliability and validity in numerous studies (33,34). The SAS and SDS are widely used as screening tools, covering affective, psychological, and somatic symptoms associated with anxiety and depression, respectively (21,35). The PSQI, a 19-item self-report questionnaire that measures subjective sleep quality, has shown good reliability and validity for both healthy and clinical groups with mental and physical health problems (36).…”

Section: Discussionmentioning

confidence: 99%

“…Leptin, the first discovered and the most studied adipokine, maintains energy homeostasis and controls body weight (19). Accumulating evidence has shown that leptin may modulate withdrawal-induced craving in alcoholic individuals (20,21). Serum leptin levels have been reported to be altered in alcoholdependent patients (22,23).…”

Section: Introductionmentioning

confidence: 99%

Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients

Wang

Zhai

et al. 2021

Front. Psychiatry

Self Cite

View full text Add to dashboard Cite

Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of this study was to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS and plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and leptin levels in patients with alcohol dependency. A total of 114 patients with alcohol dependence were randomly divided into two groups: the treatment group and the control group. The patients in the treatment group were treated with taVNS of the bilateral auricular concha using an ear vagus nerve stimulator. The Pennsylvania Alcohol Craving Scale was used to evaluate the extent of craving for alcohol. The Self-Rating Anxiety Scale and Self-Rating Depression Scale (SDS) were used to evaluate the extent of anxiety and depression symptoms, respectively. The Pittsburgh Sleep Quality Index (PSQI) was used to assess sleep quality. Enzyme-linked immunosorbent assay was used to measure plasma BDNF, IL-6, TNF-α, and leptin levels. The results showed that the SDS and PSQI scores were significantly lower in the treatment group than in the control group. Moreover, compared with the control group, the average BDNF levels in the treatment group were significantly increased. These results suggest that taVNS could improve the depression symptoms and sleep quality in alcohol-dependent patients after withdrawal, which might be related to the upregulation of plasma BDNF levels.

show abstract

“…In the central nervous system, β-END contributes to the positive reinforcement and motivational properties of drugs of abuse. In addition, there is an evidence that lowered plasma β-END during alcohol withdrawal may contribute to their experienced anxiety ( 19 , 20 ). Moreover, it is reported that the POMC gene expression is associated with anxiety-like behavior in those that experienced maternal deprivation ( 21 ).…”

Section: Introductionmentioning

confidence: 99%

The Interaction Between POMC rs2071345 Polymorphism and Alcohol Dependence in Anxiety Symptoms Among Chinese Male Problem Drinkers

et al. 2022

View full text Add to dashboard Cite

ObjectiveAlcohol dependence can increase the level of anxiety. A growing body of research has identified a link between anxiety symptoms of problem drinkers and their genetic or environment factors, respectively. However, to date few studies have directly examined gene-environment (G × E) interaction on their anxiety symptoms during the acute alcohol withdrawal. The present study aims to examine the interaction between the proopiomelanocortin (POMC) rs2071345 polymorphism and alcohol dependence on anxiety symptoms of male problem drinkers, and further test the exact form of interaction on two competing models: the diathesis-stress model vs. the differential susceptibility model.MethodsA total of 440 male problem drinkers (Mage = 44.5 years, SD = 9.45) were recruited from nine main psychiatric hospitals of northern China during acute alcohol withdrawal. Blood samples were collected for genotyping, self-reported anxiety symptoms, and levels of alcohol dependence were assessed.ResultsResults indicated that the POMC rs2071345 polymorphism significantly moderated anxiety symptoms associated with alcohol dependence. A region of significance (RoS) test showed that male problem drinkers with T allele were more likely to experience more anxiety symptoms than those with CC homozygote when the standardized score of concurrent alcohol dependence was above 0.31. Confirmatory model evaluation indicated that the interaction effect involving POMC gene polymorphism conformed to the diathesis-stress model rather than differential-susceptibility model of person × environment interaction.ConclusionsThis study suggested that the SNP in POMC rs2071345 was associated with alcohol dependence in anxiety symptoms of male problem drinkers and further provided evidence in support of the diathesis-stress hypothesis of alcohol dependence in terms of anxiety symptoms.

show abstract

Evidence of a Relationship Between Plasma Leptin, Not Nesfatin-1, and Craving in Male Alcohol-Dependent Patients After Abstinence

Cited by 10 publications

References 41 publications

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

Inflammatory Markers in Substance Use and Mood Disorders: A Neuroimaging Perspective

Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients

The Interaction Between POMC rs2071345 Polymorphism and Alcohol Dependence in Anxiety Symptoms Among Chinese Male Problem Drinkers

Contact Info

Product

Resources

About