Brain-derived neurotrophic factor and glutathione peroxidase as state biomarkers in alcohol use disorder patients undergoing detoxification

Wu, Shu-Yu; Chen, Chien‐Yu; Huang, Tiao‐Lai; Tsai, Meng-Chang

doi:10.1097/md.0000000000019938

Cited by 8 publications

(15 citation statements)

References 51 publications

(75 reference statements)

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“…This may be explained by a compensatory mechanism to eliminate possible O 2 - excess. Previous studies had similar results ( 8 ), with decreased concentrations in ethanol users ( 10 , 11 , 24 ) and with no difference between groups ( 27 , 29 ).…”

Section: Discussionsupporting

confidence: 61%

“…Studies that used the TBARS method to determinate MDA activity also reported higher levels in ethanol users ( 9 - 12 , 23 , 24 ). Other studies also reported increased MDA activity, but the difference was not significant ( 25 - 27 ). When MDA was evaluated in red blood cells, again higher results were found in ethanol users ( 21 ).…”

Section: Discussionmentioning

confidence: 78%

“…In some studies, detoxification did not cause a significant alteration in SOD concentrations ( 10 , 11 , 27 , 28 ). Others found decreased concentration compared to values at hospital admission ( 8 , 29 ).…”

Section: Discussionmentioning

confidence: 97%

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Evaluation of oxidative stress markers in ethanol users

Moraes

Dries

Seibert

et al. 2023

Braz J Med Biol Res

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Ethanol is a central nervous system depressant that is widely consumed worldwide. When consumed chronically, it may have several consequences to the organism, such as oxidative stress. Ethanol metabolism increases the production of oxidant molecules and its consumption may cause changes in enzymatic and non-enzymatic systems that maintain cellular homeostasis. The activity of endogenous enzymes and lipid peroxidation are altered in alcohol consumers. Therefore, this study aimed to evaluate oxidative stress parameters in ethanol users compared to a control group. For that, the activity of the enzymes superoxide dismutase, catalase, and glutathione peroxidase, the ferric reducing/antioxidant power (FRAP), and malondialdehyde were evaluated. The influence of the amount of ethanol consumed on the analyzed parameters was also verified. The group of alcohol users consisted of 52 volunteers, 85% male and 15% female, with a mean age of 41±13 years. The control group consisted of 50 non-drinkers, 40% male and 60% female, with a mean age of 50±10 years. There was a significant difference in superoxide dismutase (P<0.001) and malondialdehyde (P=0.007) measurements between groups, as both parameters were increased in the group of ethanol users. Because of the higher amount of ethanol consumed, there was an increase of the catalase activity parameters and gradual reduction of FRAP. Thus, the ethanol-consuming participants were most likely under oxidative stress.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 78%

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Evaluation of oxidative stress markers in ethanol users

Moraes

Dries

Seibert

et al. 2023

Braz J Med Biol Res

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“…The pathophysiology of AUD is not clear. BDNF might be related to neuronal plasticity and the reward system [ 61 ]. A study investigating BDNF serum and oxidative stress markers in AUD during alcohol detoxification reported that oxidative stress markers serum levels were significantly higher in the AUD patients, while BDNF levels were lower.…”

Section: Resultsmentioning

confidence: 99%

“…After alcohol detoxification treatment, the GPX levels in the AUD group dropped, and the BDNF levels rose. The authors suggested that serum BDNF and GPX levels might be state biomarkers for AUD patients undergoing alcohol detoxification [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

Alcohol-Induced Oxidative Stress and the Role of Antioxidants in Alcohol Use Disorder: A Systematic Review

2022

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Alcohol use disorder (AUD) is a highly prevalent, comorbid, and disabling disorder. The underlying mechanism of ethanol neurotoxicity and the involvement of oxidative stress is still not fully elucidated. However, ethanol metabolism has been associated with increased oxidative stress through alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase metabolic pathways. We searched the PubMed and genome-wide association studies (GWAS) catalog databases to review the literature systematically and summarized the findings focusing on AUD and alcohol abstinence in relation to oxidative stress. In addition, we reviewed the ClinicalTrials.gov resource of the US National Library of Medicine to identify all ongoing and completed clinical trials that include therapeutic interventions based on antioxidants. The retrieved clinical and preclinical studies show that oxidative stress impacts AUD through genetics, alcohol metabolism, inflammation, and neurodegeneration.

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