Association of T-helper cell cytokine level with age in patients with biliary atresia: a preliminary study

Li, Fu-Bang; Shu, Xiaoli; Gu, Weizhong; Zhao, Xiyang; Huang, Shoujiang; Zhao, Hong; Peng, Kui; Tou, Jinfa

doi:10.1007/s12519-018-0183-1

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…The pathogenesis of BA mainly includes embryonic development defects, genetic factors, environmental toxins, viral infections, abnormal in ammation and autoimmunity [8] . Most people believed that in ammatory reaction played a crucial role in the pathogenesis of BA [9] , which was manifested as persistent in ammatory reaction of the intrahepatic and extrahepatic bile ducts. In ammatory response destroyed the intrahepatic bile duct and liver structure, leading to progressive bile duct obstruction and liver brosis.…”

Section: Discussionmentioning

confidence: 99%

“…It was suggested that the higher level of liver in ammation, the lower the decrease rate of TBIL after operation and worse prognosis. Mohanty et al [9] proposed that age has nothing to do with the expression levels of IL-6 and TGF-6 in liver tissues. Our research found that the levels of CD4 + T cells, IL-6, IL-8 and IL-33 in liver of patients aged 60 to 90 days were slightly lower than those in ≤ 60 days and ≥ 90 days groups.…”

Section: Discussionmentioning

confidence: 99%

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Relationship between the expression levels of CD4+T cells, IL-6, IL-8 and IL-33 in liver of biliary atresia and postoperative cholangitis, operative age and jaundice clearance

Zhang

Cheng

Zheng

et al. 2022

Preprint

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Objective: To investigate the expression levels of CD4+T cells, IL-6, IL-8,and IL-33 in liver tissue of BA, and the relationship with postoperative cholangitis, operative age and early jaundice clearance.Methods: 45 cases of jaundice treated in hospital from June 2018 to May 2020 were analyzed retrospectively. The expression and distribution of these factors were detected by HE staining and immunohistochemistry, the total bilirubin level and the incidence of cholangitis were recorded, and the relationship between liver inflammation level and the postoperative incidence of cholangitis, age of operation and early jaundice clearance were compared.Results: Immunohistochemistry showed that the expression of CD4+T cells, IL-6, IL-8 and IL-33 in BA group were higher than those in CBD group. ROC curve analysis showed the AUC of CD4+T cells, IL-6 and IL-8 were 0.869, 0.886 and 0.838, respectively. The expression level of CD4+T cells was negatively correlated with the decline rate of TBIL 3 months postoperatively, and the expressions of IL-8 and IL-33 were negatively correlated with the decline rate of TBIL 1 week postoperatively. Conclusion: The high expression of CD4+T cells, IL-6, IL-8 and IL-33 in the BA liver tissue may lead to cholangitis and can be used as a predictor of early jaundice clearance. The degree of liver inflammation infiltration had nothing to do with the age of operation and is not a risk factor for postoperative cholangitis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Relationship between the expression levels of CD4+T cells, IL-6, IL-8 and IL-33 in liver of biliary atresia and postoperative cholangitis, operative age and jaundice clearance

Zhang

Cheng

Zheng

et al. 2022

Preprint

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“…Recent studies suggested that BA may be an immune disease mediated by T cells (7,8), and T cells and cytokines play a pivotal role in the osteogenesis of BA (9). Through the stimulation of specific antigens, the selective distribution of the T cell receptor (TCR, TR) spectrum could reflect the clonal amplification and functional changes of the Tcell population (10).…”

Section: Introductionmentioning

confidence: 99%

Altered T-Cell Receptor β-Chain and Lactate Dehydrogenase Are Associated With the Immune Pathogenesis of Biliary Atresia

Lai

Cao

et al. 2021

Front. Med.

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Background: Biliary atresia (BA) is considered to be an autoimmune-mediating inflammatory injury. The pathogenesis of BA has been proposed with the clonal transformation of T cells expressing analogous T-cell receptor β-chain variable regions (TRBVs).Methods: The TRBV profile of the peripheral blood mononuclear cells (PBMCs) in infants with BA and control infants (healthy donors, HDs), respectively, were characterized by using high-throughput sequencing (HTS). The diversity of T cells was analyzed based on the frequency of complementarity-determining region 3 (CDR3) or V(CDR3)J. Moreover, the correlation between absolute lymphocyte count (ALC) and lactate dehydrogenase (LDH) or diversity (clonality) indices, respectively, were analyzed for subjects with BA and HD.Results: The diversity indices of CDR3, V(CDR3)J in BA are lower than those in subjects with HD, in addition, there are significantly different levels of neutrophile, neutrophile/lymphocyte ratio (NLR), and LDH between groups of BA and HD. The correlation between ALC and diversity index is significant in subjects with HD but is not for subjects with BA. Conversely, the relationship between ALC and LDH is significant in subjects with BA but is not for subjects with HD. Moreover, 12 CDR3 motifs are deficient or lower expression in BA compared with that in the HD group.Conclusion: Our results demonstrate that the profile of TRBV repertoire is significantly different between subjects with BA and HD, and suggest that the immune imbalance and elevated LDH level are associated with the pathogenesis of BA. Moreover, the values of neutrophile, NLR, and LDH could be used for the differential diagnosis of BA.

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Relationship between the expression levels of CD4+ T cells, IL-6, IL-8 and IL-33 in the liver of biliary atresia and postoperative cholangitis, operative age and early jaundice clearance

et al. 2022

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Association of T-helper cell cytokine level with age in patients with biliary atresia: a preliminary study

Abstract: The serum levels of IL-1β, IL-6, IL-10 and IL-12p70 showed significant age-related differences in patients with BA. Interpretation of the role of cytokines in BA needs to take patient's age into consideration.

Cited by 3 publications

References 18 publications

Relationship between the expression levels of CD4+T cells, IL-6, IL-8 and IL-33 in liver of biliary atresia and postoperative cholangitis, operative age and jaundice clearance

Relationship between the expression levels of CD4+T cells, IL-6, IL-8 and IL-33 in liver of biliary atresia and postoperative cholangitis, operative age and jaundice clearance

Altered T-Cell Receptor β-Chain and Lactate Dehydrogenase Are Associated With the Immune Pathogenesis of Biliary Atresia

Relationship between the expression levels of CD4+ T cells, IL-6, IL-8 and IL-33 in the liver of biliary atresia and postoperative cholangitis, operative age and early jaundice clearance

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