Relationship between the expression levels of CD4+ T cells, IL-6, IL-8 and IL-33 in the liver of biliary atresia and postoperative cholangitis, operative age and early jaundice clearance

Zhang, Kaizhi; Chen, Yutong; Zheng, Zebing; Tang, Chengyan; Zhu, Daiwei; Xia, Xingrong; Huang, Lu; Du, Qing; Liu, Yuanmei; Jin, Zhu

doi:10.1007/s00383-022-05258-0

Cited by 4 publications

(1 citation statement)

References 29 publications

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“…Ramachandran et al ( 25 ) showed that increased episodes of postoperative cholangitis were a predictor of poor outcome after KPE. Additionally, repeated episodes of postoperative cholangitis seem to be associated with a worse outcome for BA patients ( 26 , 27 ). Calinescu et al ( 7 ) found that the greater the occurrence of cholangitis, the lower the NLS rate.…”

Section: Discussionmentioning

confidence: 99%

Early bile drainage improves native liver survival in biliary atresia without cholangitis

Liu

Liang

et al. 2023

Front. Pediatr.

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ObjectivesTo explore the outcomes and related factors in children without cholangitis after Kasai portoenterostomy (KPE).MethodsWe retrospectively analyzed the data of infants with type III BA who underwent KPE from June 2016 to December 2021. We compared and analyzed the difference in native liver survival (NLS) rates in different types of cholangitis. We also investigated the relationship between the absence of cholangitis and the effect of early bile drainage (EBD) as well as the related factors affecting EBD efficacy.ResultsA total of 145 children were included in this study. Among these children, 82 (56.6%, 82/145) had cholangitis, including 40 (48.8%, 40/82) with early cholangitis and 33 (40.2%, 33/82) with recurrent cholangitis. The median follow-up period was 29 months (range, 2–75 months). The NLS rates were 67.6%, 51.7%, 45.5% and 43.4% at 6 months, 1 year, 2 years and 5 years following KPE, while the NLS rates for infants without cholangitis after KPE were 68.3%, 50.8%, 46.0% and 46.0%, respectively. Higher gamma-glutamyl transferase (γ- GT) and total bile acid (TBA) before KPE were risk factors for cholangitis (P < 0.05). The NLS rate in recurrent cholangitis was significantly lower than that in occasional cholangitis (P < 0.01). Compared with the EBD-poor group, the NLS rate in the EBD-good group of infants was significantly increased (P < 0.001). EBD was significantly correlated with the occurrence and frequency of cholangitis (P < 0.05).ConclusionsRecurrent cholangitis was an important factor affecting NLS. For children without cholangitis after KPE, early bile drainage was better, and the NLS was longer.

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Section: Discussionmentioning

confidence: 99%

Early bile drainage improves native liver survival in biliary atresia without cholangitis

Liu

Liang

et al. 2023

Front. Pediatr.

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Retrospective analysis of the standardized BARD criteria for acute cholangitis in biliary atresia patients

Madadi‐Sanjani,

Calinescu,

Rock

et al. 2024

JPGN rep.

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ObjectivesIn 2022, the Biliary Atresia and Related Diseases (BARD) community reached a consensus for the definition of suspected and confirmed cholangitis for biliary atresia (BA) patients after hepatoportoenterostomy (HPE). This study assessed the new standardized BARD definition in a retrospective, multicenter cohort study.MethodsWe included BA cases managed between 2010 and 2020 at the Hannover Medical School and Geneva University Hospitals' Swiss Pediatric Liver Center. The standardized BARD cholangitis definition assesses four clinical items and four imaging/laboratory items to define cholangitis. The definition was retrospectively applied to all BA cases having presented, according to their physician, cholangitis within the first year after the HPE. The diagnosis defined by the standardized BARD definition was compared with the final clinical diagnosis made by physicians. The Spearman's correlation coefficient was used to test for correlation between diagnoses made by standardized and clinical appreciation.ResultsOf 185 consecutive BA patients, 59 (32%) had at least one episode of cholangitis within the first year after HPE. The correlation between the clinician's impression and the standardized BARD definition was very strong (r = 0.8). Confirmed cholangitis definition coincided with the clinician's impression (2.5 [±0.7]/4 clinical items, 2.6 [±0.5]/4 imaging/laboratory items). For suspected cholangitis, the threshold for diagnosis was lower within the standardized BARD definition (1.1 [±0.3]/4 clinical items, 2.2 [±0.8]/4 laboratory/imaging items).ConclusionsThis first retrospective application of the standardized BARD cholangitis definition reveals a very strong correlation with the physician's assessment before standardization. A prospective study is needed to further refine the standardized definition for cholangitis in BA patients.

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A convenient nomogram for predicting early death or liver transplantation after the Kasai procedure in patients with biliary atresia

Lu,

Xie,

Zhu

et al. 2024

Langenbecks Arch Surg

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Relationship between the expression levels of CD4+ T cells, IL-6, IL-8 and IL-33 in the liver of biliary atresia and postoperative cholangitis, operative age and early jaundice clearance

Cited by 4 publications

References 29 publications

Early bile drainage improves native liver survival in biliary atresia without cholangitis

Early bile drainage improves native liver survival in biliary atresia without cholangitis

Retrospective analysis of the standardized BARD criteria for acute cholangitis in biliary atresia patients

A convenient nomogram for predicting early death or liver transplantation after the Kasai procedure in patients with biliary atresia

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