Association of serum total fatty acids with type 2 diabetes

Li, Na; Qiu, Yuhan; Wu, Yunpeng; Zhang, Mo; Lai, Zhizhen; Wang, Qing; Du, Yuying; Guo, Lei; Liu, Shuai; Li, Zhili

doi:10.1016/j.cca.2019.09.018

Cited by 7 publications

(18 citation statements)

References 50 publications

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“…Previous studies have attempted to link the change of both FFAs and total FAs with T2D diagnosis and therapy ( 49 ). The alteration of total FA profile at sum composition level was observed among hundreds of control, prediabetes, and diabetes sample ( 50 ). However, plasma lipids are often subjected to large concentration fluctuations due to diet and lifestyle ( 50 ), making it difficult for the discovery of plasma lipid markers.…”

Section: Resultsmentioning

confidence: 99%

“…The alteration of total FA profile at sum composition level was observed among hundreds of control, prediabetes, and diabetes sample ( 50 ). However, plasma lipids are often subjected to large concentration fluctuations due to diet and lifestyle ( 50 ), making it difficult for the discovery of plasma lipid markers. In previous studies, we found that the relative compositions of C=C location isomers were much less affected by interpersonal variations and the relative ratios of C18:1 n-9/n-7 isomers from several PC, PE, and PI molecules exhibited significant differences between control and T2D samples ( 29 , 51 ).…”

Section: Resultsmentioning

confidence: 99%

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A liquid chromatography-mass spectrometry workflow for in-depth quantitation of fatty acid double bond location isomers

Zhao

Fang

Xia

2021

Journal of Lipid Research

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A liquid chromatography-mass spectrometry workflow for in-depth quantitation of fatty acid double bond location isomers

Zhao

Fang

Xia

2021

Journal of Lipid Research

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“…Besides, alterations in the fatty acid content in the blood have been associated with type 2 diabetes in humans (Li et al, 2020) and these alterations have also been demonstrated in the testis following the establishment of diabetes in rats (Starcevic, Mauric, Galan, Gudan Kurilj, & Masek, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…For example, elevated levels of malondialdehyde—a major stable product of extensive PUFA peroxidation—have been measured in diabetic testes (Shoorei et al., 2019). Besides, alterations in the fatty acid content in the blood have been associated with type 2 diabetes in humans (Li et al., 2020) and these alterations have also been demonstrated in the testis following the establishment of diabetes in rats (Starcevic, Mauric, Galan, Gudan Kurilj, & Masek, 2018).…”

Section: Introductionmentioning

confidence: 99%

Centella asiaticaalleviates diabetes‐induced changes in fatty acid profile and oxidative damage in rat testis

et al. 2020

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The in vivo effects of Centella asiatica L. Urban (Family: Apiaceae; CA) on diabetesinduced testicular fatty acid misdistribution and oxidative injury were investigated. Diabetic rats were treated with vehicle, CA or metformin daily for 14 days by oral gavage. Fatty acid (FA) content in testis was analysed using gas chromatographyflame ionisation detection while redox indices were measured as peroxide value (PV), malondialdehyde (MDA), oxygen radical antioxidant capacity (ORAC), reduced glutathione (GSH), glutathione S-transferase (GST) and glutathione peroxidase (GPx) activities. Diabetes increased omega-6 (61%), and decreased omega-3 (23%) and monounsaturated fatty acids (MUFA; 18%) compared to non-diabetic controls. Oxidative injury in diabetic rats was confirmed by increases in PV (112%) and MDA (77%) in addition to decreases in GSH (41%) and activities of GST (19%) & GPx (24%) compared to non-diabetic controls. CA treatment led to 17% reduction in omega-6 and 33% rise in MUFA compared to diabetic controls. Additionally, CA ameliorated the oxidative injury and improved antioxidant capacity by increasing GSH (49%), GST (16%) and GPx (23%) when compared to diabetic controls. Data suggest CA potential in alleviating the alterations caused by diabetes in testes through effects on omega-6 and MUFA; and via increased GSH level and dependent enzyme activities.

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“…[18][19][20][21] However, there are only few publications presenting LDI approaches to detect these compounds. 17,22,23 In this work, we present for the first time results aimed at detection and quantification of carboxylic acids with the use of surfaceassisted LDI MS based on two nanoparticle systems: 109 AgNPs and AuNPs.…”

Section: Introductionmentioning

confidence: 99%

Gold and silver nanoparticles‐based laser desorption/ionization mass spectrometry method for detection and quantification of carboxylic acids

2020

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A comparison of ionization efficiency for gold and silver nanoparticles used as an active media of matrix-less laser desorption/ionization (LDI) mass spectrometry (MS) methods was made for carboxylic acids including fatty acids. The matrix-assisted laser desorption/ionization (MALDI)-type targets containing monoisotopic cationic 109 Ag nanoparticles (109 AgNPs) and Au nanoparticles (AuNPs) were used for rapid MS measurements of 10 carboxylic acids of different chemical properties. Carboxylic acids were directly quantified in experiments with 10 000-fold concentration change conditions ranging from 1 mg/ml to 100 ng/ml which equates to 1 μg to 100 pg of carboxylic acids per measurement spot.

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Association of serum total fatty acids with type 2 diabetes

Cited by 7 publications

References 50 publications

A liquid chromatography-mass spectrometry workflow for in-depth quantitation of fatty acid double bond location isomers

A liquid chromatography-mass spectrometry workflow for in-depth quantitation of fatty acid double bond location isomers

Centella asiaticaalleviates diabetes‐induced changes in fatty acid profile and oxidative damage in rat testis

Gold and silver nanoparticles‐based laser desorption/ionization mass spectrometry method for detection and quantification of carboxylic acids

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