Association of serum sialic acid with cardiovascular metabolic risk factors in Kuwaiti children and adolescents with type 1 diabetes

Moussa, Mohamed; Alsaeid, Mayra; Refai, T. M. K.; Abdella, Nabila; Al-Sheikh, Nashami; Gomez, Joseph E.

doi:10.1016/j.metabol.2003.11.013

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…9,22,23 Nevertheless, there is one study in which lower selfesteem was found among diabetic children compared with healthy children, but the authors did not find any significant differences in the children's expectations from life between the two groups. 24 Moreover, although diabetes mellitus tends to cause psychological morbidity, Vila et al, in a comparative study, found that a group of asthmatic children comparable for age, sex and socioeconomic status had more psychopathological problems than patients with insulin-dependent diabetes mellitus. 14,25 Some studies have indicated that chronically ill adolescent girls have more emotional problems and suicidal tendencies than their male counterparts; 26,27 however, others have shown that males are more severely affected by the illness.…”

Section: Discussionmentioning

confidence: 99%

Assessment of self‐reported self‐esteem in healthy and diabetic children and adolescents in Greece

Vlachioti¹,

Petsios

Boutopoulou

et al. 2010

Journal of Diabetes

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Background: The aim of the present study was to evaluate any possible negative effect of diabetes on the self‐esteem of children and adolescents with diabetes. Methods: Self‐esteem was evaluated using the Culture‐Free Self‐Esteem Inventory (CFSEI‐2) in 144 patients with Type 1 diabetes mellitus (T1DM; 7–18 years of age) treated in a diabetes center and compared against that of 136 healthy children and adolescents. Results: Self‐esteem was correlated with age (P = 0.017), but not with diabetes (P = 0.886). The median CFSEI‐2 score for both healthy and diabetic children was 22. There was no significant correlation between self‐esteem and sex, body mass index (BMI), physical exercise, HbA1c or parental educational level. According to Spearman’s rank correlation coefficient (rs), there was a significant association between age and self‐esteem (rs = −0.15). Conversely, although BMI (rs = −0.09) and treatment duration (rs = −0.107) had a slight negative effect on self‐esteem and the duration of physical exercise (rs = 0.11) and parental education (rs = 0.07) seemed to have a positive effect, the associations did not reach statistical significance. Conclusions: Self‐esteem in diabetic children is mainly affected by their age, level of physical activity and level of family support. These findings emphasize the need to discriminate between glycemic control and diabetic adjustment.

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Section: Discussionmentioning

confidence: 99%

Assessment of self‐reported self‐esteem in healthy and diabetic children and adolescents in Greece

Vlachioti¹,

Petsios

Boutopoulou

et al. 2010

Journal of Diabetes

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“…Serum sialic acid is almost completely bound to glycoproteins and lipids. Total sialic acid in the serum has received considerable attention as a possible marker for cardiovascular disease and mortality (Moussa et al 2004). In diabetes mellitus, the serum concentration of serum sialic acid was found to increase significantly (Gavella et al 2003).…”

Section: Discussionmentioning

confidence: 99%

Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats

Senthilkumar¹,

Subramanian²

2008

J Appl Biomed

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This study was designed to evaluate the effect of Terminalia chebula fruit extract on the levels of plasma and tissue glycoprotein components in streptozotocin-induced-diabetic rats. Oral administration of T. chebula fruit extract at a concentration of 200 mg/kg body weight for 30 days significantly reduced the levels of blood glucose, glycosylated hemoglobin, urea, and creatinine as well as fucose, hexose, hexosamine and sialic acid in the diabetic rats treated with the fruit extract. The observed decrease in the levels of plasma insulin and C-peptide in the diabetic rats was elevated to near normal by T. chebula fruit extract treatment. Histological observations made on the pancreatic tissue of control and experimental groups also revealed the beneficial effect of T. chebula fruit extract. The efficacy of the fruit extract was comparable with glibenclamide, a known hypoglycaemic drug.

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“…However, a significant correlation was found between serum total SA and total cholesterol, triglyceride and apolipoprotein B [Moussa et al 2004]…”

Section: Sialic Acid (Sa)mentioning

confidence: 99%

Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population

Lee

Patel

Jones

et al. 2015

Therapeutic Advances in Chronic Disease

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Cardiovascular disease (CVD) is a major cause of mortality in type 1 diabetes mellitus (T1D). However, evidence of its risks and management is often extrapolated from studies in type 2 diabetic (T2D) patients or the general population. This approach is unsatisfactory given that the underlying pathology, demographics and natural history of the disease differ between T1D and T2D. Furthermore, with a rising life expectancy, a greater number of T1D patients are exposed to the cardiovascular (CV) risk factors associated with an ageing population. The aim of this review is to examine the existing literature around CVD in T1D. We pay particular attention to CVD prevalence, how well we manage risk, potential biomarkers, and whether the studies included the older aged patients (defined as aged over 65). We also discuss approaches to the management of CV risk in the older aged. The available data suggest a significant CVD burden in patients with T1D and poor management of CV risk factors. This is underpinned by a poor evidence base for therapeutic management of CV risk specifically for patients with T1D, and in the most relevant population -the older aged patients. We would suggest that important areas remain to be addressed, particularly exploring the risks and benefits of therapeutic approaches to CVD management in the older aged.

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Association of serum sialic acid with cardiovascular metabolic risk factors in Kuwaiti children and adolescents with type 1 diabetes

Cited by 13 publications

References 31 publications

Assessment of self‐reported self‐esteem in healthy and diabetic children and adolescents in Greece

Assessment of self‐reported self‐esteem in healthy and diabetic children and adolescents in Greece

Biochemical studies on the effect of Terminalia chebula on the levels of glycoproteins in streptozotocin-induced experimental diabetes in rats

Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population

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