Association of Sensory Impairments With Cognitive Decline and Depression Among Older Adults in China

Rong, Hongguo; Lai, Xiaozhen; Jing, Rize; Wang, Xiao; Fang, Hai; Mahmoudi, Elham

doi:10.1001/jamanetworkopen.2020.14186

Cited by 85 publications

(98 citation statements)

References 61 publications

(110 reference statements)

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“…There is concern that the coronavirus disease 2019 (COVID-19) pandemic has negatively impacted depressive and anxiety symptoms [ 1 , 18 , 33 ], especially among young adults aged 18–25 years [ 10 , 20 , 26 , 36 ]. While young adulthood is generally a period of good physical health, mental health problems are common [ 19 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort

et al. 2021

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Background Concerns have been raised that the COVID-19 pandemic could increase risk for adverse mental health outcomes, especially in young adults, a vulnerable age group. We investigated changes in depression and anxiety symptoms (overall and severe) from before to during the pandemic, as well as whether these changes are linked to COVID-19-related stressors and pre-existing vulnerabilities in young adults followed in the context of a population-based cohort. Method Participants (n = 1039) from the Quebec Longitudinal Study of Child Development reported on their depression (Centre for Epidemiological Studies Depression Scale, short form) and anxiety (General Anxiety Disorder-7 Scale) symptoms and completed a COVID-19 questionnaire during the first wave of the COVID-19 pandemic in the summer of 2020 (age 22 years). Assessments at age 20 (2018) were used to estimate pre-pandemic depression and anxiety symptom severity. Results While mean levels of depression and anxiety symptoms did not change from before to during the first wave of the COVID-19 pandemic (e.g., the mean of depressive symptoms was 9.30 in 2018 and 9.59 in 2020), we observed a slight increase in rates of severe depression (scores ≥ 21) from before (6.1%) to during (8.2%) the pandemic. Most COVID-19-related variables (e.g., loss of education/occupation, frequent news-seeking) – except living alone – and most pre-existing vulnerabilities (e.g., low SES, low social support) were not associated with changes in depression or anxiety symptoms. However, results varied as a function of pre-pandemic levels of depression and anxiety: depression and anxiety symptoms increased among adults with the lowest levels of symptoms before the pandemic, while they decreased among those with the highest levels of symptoms, possibly reflecting a regression to the mean. Conclusions Depression and anxiety symptoms in young adults from Québec in Summer 2020 were mostly comparable to symptoms reported in 2018. Most COVID-19-related stressors and pre-existing vulnerabilities were not associated with changes in symptoms, except living alone and pre-existing symptoms of depression and anxiety. However, the increased rate of severe depression warrants further investigation.

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Section: Introductionmentioning

confidence: 99%

Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort

et al. 2021

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“…1 During the first wave of the pandemic, healthcare workers were worried about bringing COVID-19 home to their families and shortages of personal protective equipment (PPE), 2 and reported symptoms of depression, anxiety, insomnia, and distress. 3 …”

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confidence: 99%

Professional fulfillment, burnout, and wellness of anesthesiologists during the COVID-19 pandemic

O'Brien

Goncin

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et al. 2021

Can J Anesth/J Can Anesth

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“…Evaluation of age-related changes in somatosensory function will also necessitate consideration of biobehavioral factors such as cognitive and psychological function. Population-based studies have reported significant associations between cognitive decline, depression, and sensory deficits (eg, vision and hearing) ( 21 , 22 ). Also, research has shown that depressed mood states ( 23 ) and psychological distress ( 24 ) can influence responses to noxious stimuli.…”

Section: Background and Objectivesmentioning

confidence: 99%

Age Differences in Multimodal Quantitative Sensory Testing and Associations With Brain Volume

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Wilson

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et al. 2021

Innovation in Aging

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Background and Objectives Somatosensory function is critical for successful aging. Prior studies have shown declines in somatosensory function with age; however, this may be affected by testing site, modality, and biobehavioral factors. While somatosensory function declines are associated with peripheral nervous system degradation, little is known regarding correlates with the central nervous system and brain structure in particular. The objectives of this study were to examine age-related declines in somatosensory function using innocuous and noxious stimuli, across 2 anatomical testing sites, with considerations for affect and cognitive function, and associations between somatosensory function and brain structure in older adults. Research Design and Methods A cross-sectional analysis included 84 “younger” (n = 22, age range: 19–24 years) and “older” (n = 62, age range: 60–94 years) healthy adults who participated in the Neuromodulatory Examination of Pain and Mobility Across the Lifespan study. Participants were assessed on measures of somatosensory function (quantitative sensory testing), at 2 sites (metatarsal and thenar) using standardized procedures, and completed cognitive and psychological function measures and structural magnetic resonance imaging. Results Significant age × test site interaction effects were observed for warmth detection (p = .018, ηp2= 0.10) and heat pain thresholds (p = .014, ηp2= 0.12). Main age effects were observed for mechanical, vibratory, cold, and warmth detection thresholds (ps < .05), with older adults displaying a loss of sensory function. Significant associations between somatosensory function and brain gray matter structure emerged in the right occipital region, the right temporal region, and the left pericallosum. Discussion and Implications Our findings indicate healthy older adults display alterations in sensory responses to innocuous and noxious stimuli compared to younger adults and, furthermore, these alterations are uniquely affected by anatomical site. These findings suggest a nonuniform decline in somatosensation in older adults, which may represent peripheral and central nervous system alterations part of aging processes.

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Association of Sensory Impairments With Cognitive Decline and Depression Among Older Adults in China

Cited by 85 publications

References 61 publications

Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort

Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort

Professional fulfillment, burnout, and wellness of anesthesiologists during the COVID-19 pandemic

Age Differences in Multimodal Quantitative Sensory Testing and Associations With Brain Volume

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