Association of rs1801133 polymorphism with migraine susceptibility: A case-control study followed by updated meta-analysis and trial sequential analysis
“…We have found that the variant ”C677T” of MTHFR showed a non-significant association with the risk of overall migraine in the Indian population which supports the independent studies 13 , 16 , 18 in contrast to the positive association found by different independent studies 17 , 22 , 23 . Comparing the present pooled result with the most recent meta-analysis which discussed the association of C677T with the risk of migraine, showed a significant risk association 40 .…”
Section: Discussionsupporting
confidence: 82%
“…2 ) (Paint—Microsoft Apps). Only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis and these include six studies which have explored MTHFR gene 13 , 16 – 18 , 22 , 23 , three studies for ACE (I/D polymorphism) 13 , 17 , 24 , LRP1- rs11172113 19 , 26 , 28 , PRDM16- rs2651899 19 , 26 , TRPM8- rs10166942 and rs10504861 21 , 26 , ESR1 PvuII and XbaI 15 , 29 , 37 , DAO- rs10156191, rs2052129 20 , 35 and TNF-α G308A 25 , 30 . Figure 1 Selection of literature according to PRISMA (Preferred Reporting Items for Systematics Reviews and Meta-Analysis) guidelines.…”
Section: Resultsmentioning
confidence: 99%
“…In the present analysis, a total of 842 cases and 882 control subjects were included which were found after the inclusion of five studies representing four from the north Indian population 13 , 16 – 18 and one from the south Indian population 22 and exclusion of one study due to not found in HWE 23 (Supplementary Table 1 S1). The frequency of the risk allele was 0.195 (n = 329/1684) in contrast to the wild allele 0.804 (n = 1355/1684)within the case group while in a control group, the frequency of the risk allele was 0.168 (n = 297/1764) in contrast to wild allele i.e., 0.831 (n = 1467/1764) in the control group.…”
Migraine is a complex disorder with multigenic inheritance and is characterized by the cardinal symptom of unilateral headache. Many genes are responsible for increasing the susceptibility of disease within different populations. Therefore, our primary aim in this review was to catalog the many genes that have been studied in India and after collecting the necessary information, we calculated a more precise risk relationship between an identified variation and migraine. The gene and its associated risk variant were discovered in the Indian population using a PRISMA-based systematic literature review guideline from online databases such as PubMed & Google Scholar. We constructed pooled odds ratios with 95% confidence intervals using multiple genetic models. Also, we looked for heterogeneity using Cochran's Q Test and the I2 statistic. Publication bias was analyzed using Begg's and Egger's tests. A p-value less than 0.05 was judged to be statistically significant for all tests. After a critical analysis, a total of 24 studies explored about 21 genes with 31 variants out of which only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis. It has been found, that the ACE-DD variant (allele model: OR: 1.37 [1.11–1.69], I2 = 0%/ fixed model), ESR1-PvuII (allele model: OR: 1.47 [1.24–1.74], I2 = 0%/ fixed model) significantly increases the risk of migraine in Indian population. Also, a protective role of the LRP1-rs11172113variant was observed for both migraine and its clinical subtype i.e., MA (allelic model: OR of 0.65 [0.50–0.83] I2 = 44% and allele: OR: 0.54 [0.37–0.78], I2 = 52%) respectively. Overall, the results of this meta-analysis indicated that the ACE-DD variant and the ESR1-PvuII were associated with an increased risk of migraine in the Indian community, while the LRP1-rs11172113 variant was associated with protection from migraine in this population.
“…We have found that the variant ”C677T” of MTHFR showed a non-significant association with the risk of overall migraine in the Indian population which supports the independent studies 13 , 16 , 18 in contrast to the positive association found by different independent studies 17 , 22 , 23 . Comparing the present pooled result with the most recent meta-analysis which discussed the association of C677T with the risk of migraine, showed a significant risk association 40 .…”
Section: Discussionsupporting
confidence: 82%
“…2 ) (Paint—Microsoft Apps). Only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis and these include six studies which have explored MTHFR gene 13 , 16 – 18 , 22 , 23 , three studies for ACE (I/D polymorphism) 13 , 17 , 24 , LRP1- rs11172113 19 , 26 , 28 , PRDM16- rs2651899 19 , 26 , TRPM8- rs10166942 and rs10504861 21 , 26 , ESR1 PvuII and XbaI 15 , 29 , 37 , DAO- rs10156191, rs2052129 20 , 35 and TNF-α G308A 25 , 30 . Figure 1 Selection of literature according to PRISMA (Preferred Reporting Items for Systematics Reviews and Meta-Analysis) guidelines.…”
Section: Resultsmentioning
confidence: 99%
“…In the present analysis, a total of 842 cases and 882 control subjects were included which were found after the inclusion of five studies representing four from the north Indian population 13 , 16 – 18 and one from the south Indian population 22 and exclusion of one study due to not found in HWE 23 (Supplementary Table 1 S1). The frequency of the risk allele was 0.195 (n = 329/1684) in contrast to the wild allele 0.804 (n = 1355/1684)within the case group while in a control group, the frequency of the risk allele was 0.168 (n = 297/1764) in contrast to wild allele i.e., 0.831 (n = 1467/1764) in the control group.…”
Migraine is a complex disorder with multigenic inheritance and is characterized by the cardinal symptom of unilateral headache. Many genes are responsible for increasing the susceptibility of disease within different populations. Therefore, our primary aim in this review was to catalog the many genes that have been studied in India and after collecting the necessary information, we calculated a more precise risk relationship between an identified variation and migraine. The gene and its associated risk variant were discovered in the Indian population using a PRISMA-based systematic literature review guideline from online databases such as PubMed & Google Scholar. We constructed pooled odds ratios with 95% confidence intervals using multiple genetic models. Also, we looked for heterogeneity using Cochran's Q Test and the I2 statistic. Publication bias was analyzed using Begg's and Egger's tests. A p-value less than 0.05 was judged to be statistically significant for all tests. After a critical analysis, a total of 24 studies explored about 21 genes with 31 variants out of which only nine genes have been studied more than two times in the Indian population and thus were found eligible for the meta-analysis. It has been found, that the ACE-DD variant (allele model: OR: 1.37 [1.11–1.69], I2 = 0%/ fixed model), ESR1-PvuII (allele model: OR: 1.47 [1.24–1.74], I2 = 0%/ fixed model) significantly increases the risk of migraine in Indian population. Also, a protective role of the LRP1-rs11172113variant was observed for both migraine and its clinical subtype i.e., MA (allelic model: OR of 0.65 [0.50–0.83] I2 = 44% and allele: OR: 0.54 [0.37–0.78], I2 = 52%) respectively. Overall, the results of this meta-analysis indicated that the ACE-DD variant and the ESR1-PvuII were associated with an increased risk of migraine in the Indian community, while the LRP1-rs11172113 variant was associated with protection from migraine in this population.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
