A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression

Sudershan, Amrit; Pushap, Agar Chander; Kumar, Hardeep; Kumar, Parvinder

doi:10.1007/s12031-023-02164-5

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“…The chronification, which is more than just “one cup of tea” might be the product of a slew of molecules and is something that must be understood. It has been shown that several genes are responsible for defining one's susceptibility to migraine conditions, and these genes also indicated that they are population-specific [ 98 , 99 ].…”

Section: Discussionmentioning

confidence: 99%

Role of TNF-α in the Pathogenesis of Migraine

Sudershan,

Sharma

et al. 2024

Pain Research and Management

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Background. Neurogenic neuroinflammation has a wide role in migraine pathogenesis including the transition from episodic migraine to chronic one. The seed molecule of neurogenic neuroinflammation, i.e., the TNF-α proinflammatory molecule, has gathered a lot of attention. This pleiotropic cytokine is a classical component of inflammatory soup, secreted by the microglial cell, and promotes a wide range of inflammatory reactions. Aim. In this review, we aimed to provide a culminating and comprehending glimpse into the TNF-α in association with the migraine. Method. A systematic literature survey method with a mixture of keywords was utilized to grasp the different elements that represent the association between TNF-α and migraine. Discussion. Highlighted the probable involvement of the TNF-α with migraine, the complexity of the matter such as activation of NF-KB signaling cascade, autoactivation, sensitization, and increased likelihood of transition cannot be neglected. Being TNF-α as a core node, it becomes the factor for linking diseases such as chronic inflammatory disorders, including COVID-19, and also interaction with other genes to develop severe conditions. Conclusion. To this end, TNF-α plays a critical role in chronification, and inhibiting its signaling would likely be a crucial strategy for migraine therapy.

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Section: Discussionmentioning

confidence: 99%