Association of Radon Background and Total Background Ionizing Radiation with Alzheimer’s Disease Deaths in U.S. States

Lehrer, Steven; Rheinstein, Peter H.; Rosenzweig, Kenneth E.

doi:10.3233/jad-170308

Cited by 24 publications

(19 citation statements)

References 20 publications

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“…Plus, Radon and its daughters may also pass the blood -brain -barrier. Damage would accumulate over time making also age to be a powerful risk factor 32 . Other cohort studies evaluated health outcome medical workers exposed to IR 11,33-36 but to our knowledge none of them focused on its impact on the brain.…”

Section: Clinical Effects Of Low Dose Exposition On the Brainmentioning

confidence: 99%

Effects of Ionizing Radiation and their Potential Risk on the Brain: A Review

Salhi

Filali

2019

JEOH

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Section: Clinical Effects Of Low Dose Exposition On the Brainmentioning

confidence: 99%

Effects of Ionizing Radiation and their Potential Risk on the Brain: A Review

Salhi

Filali

2019

JEOH

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“…However, the authors recommend continuing the health supervision of this population (from HBRA) in the future [27,28]. Lehrer, S. et al, 2017 found the strong correlation between natural background radiation and risk of developing Alzheimer Disease [29]. Still, this question is under discussion, as there are might be ecological fallacy.…”

mentioning

confidence: 98%

“…The other 19 papers recommended conducting long-term research. Only in one paper was found neurological disorder, such as Alzheimer's disease (AD) [29].According to the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR), there are four main sources, which form the Natural Background Radiation: cosmic rays, terrestrial radiation, intakes of naturally occurring radionuclides through inhalation and ingestion.…”

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confidence: 99%

The Impact of the Background Radiation on the Health

Туруспекова¹,

Tsoy²

2019

OF THE NATIONAL ACADEMY OF SCIENCES OF THE REPUBLIC OF KAZAKHST

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Abzhanov Arkhat, prof. (Boston, USA), Abelev S.K., prof. (Moscow, Russia), Aitkhozhina N.А., prof., academician (Kazakhstan) Akshulakov S.K., prof., academician (Kazakhstan) Alchinbayev М.K., prof., academician (Kazakhstan) Batpenov N.D., prof., corr. member (Kazakhstan) Berezin V.Ye., prof., corr. member. (Kazakhstan) Bersimbayev R.I., prof., academician (Kazakhstan) Berkinbaev S.F., prof. (Kazakhstan) Bisenbayev А.K., prof., academician (Kazakhstan) Bishimbayeva N.K., prof., academician (Kazakhstan) Botabekova Т.K., prof., corr. member. (Kazakhstan) Bosch Ernesto, prof. (Spain) Davletov Kairat, PhD, associate professor, executive Secretary Dzhansugurova L.B., Cand. biol., prof. (Kazakhstan) Ellenbogen Adrian, prof. (Tel-Aviv, Israel), Zhambakin K.Zh., prof., academician (Kazakhstan), deputy editor-in-chief Ishchenko Alexander, prof. (Villejuif, France) Isayeva R.B., prof. (Kazakhstan) Kaydarova D.R., prof., academician (Kazakhstan) Kokhmetova A., prof., corr. member (Kazakhstan) Kuzdenbayeva R.S., prof., academician (Kazakhstan) Lokshin V.N., prof., corr. member (Kazakhstan) Los D.А., prof. (Moscow, Russia) Lunenfeld Bruno, prof. (Israel) Makashev E.K., prof., corr. member (Kazakhstan) Mitalipov Sh.M. (America) Muminov Т.А., prof., academician (Kazakhstan) Ogar N.P., prof., corr. member (Kazakhstan) Omarov R.T., cand. biol., prof. (Kazakhstan) Prodeus A.P., prof. (Russia) Purton Saul, prof. (London, UK) Rakhypbekov Т.K., prof., corr. member. (Kazakhstan) Saparbayev Мurat, prof. (Paris, France) Sarbassov Dos, prof. (Houston, USA) Turysbekov E.K., cand. biol., assoc. prof. (Kazakhstan) Sharmanov A.T., prof. (USA) News of the National Academy of Sciences of the Republic of Kazakhstan. Series of biology and medicine.

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“…Injury to the brain from trauma or irradiation may initiate the process [3]. The characteristic pathologic plaques and tangles are a non-specific result of the disease process, not a cause [4].…”

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confidence: 99%

Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database

Lehrer

Rheinstein²

2018

ADR

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Background:Studies of Alzheimer’s disease suggest that neuroinflammation or deranged brain wound healing may be a cause of some cases. But a placebo controlled study showed no effect at all on Alzheimer’s disease of low dose oral prednisone after one year. Introducing the steroid directly into the hippocampus and rhinencephalon via the nose, as happens in hay fever subjects, could be more effective.Objective:In the present study, we analyzed FDA MedWatch data for intranasal fluticasone propionate (Flonase) to determine the frequency of Alzheimer’s disease as an adverse event reported after use of the medication.Methods:Machine-readable data from MedWatch, including adverse drug reaction reports from manufacturers, are part of a public database. We used the online tool eHealthMe to query the database.Results:By September 20, 2017, 35,221 people reported side effects to MedWatch after taking Flonase. Among them, 9 people (0.03%) had Dementia Alzheimer’s type. By October 3, 2017, 185,636 people reported side effects after taking Lipitor. Among them, 243 people (0.13%) had Dementia Alzheimer’s type. The lower incidence of Alzheimer’s dementia in the Flonase group compared to the Lipitor group was significant (p < 0.001, Fisher exact test, two tailed).Conclusion:Long term use of oral non-steroidal anti-inflammatory drugs (NSAIDs) is linked with reduced risk of developing Alzheimer’s disease. Data from MedWatch suggest that fluticasone propionate administered intranasally might have a similar preventive effect to ibuprofen. Perhaps combining ibuprofen and Flonase could be therapeutic. Further studies would be desirable.

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Association of Radon Background and Total Background Ionizing Radiation with Alzheimer’s Disease Deaths in U.S. States

Cited by 24 publications

References 20 publications

Effects of Ionizing Radiation and their Potential Risk on the Brain: A Review

Effects of Ionizing Radiation and their Potential Risk on the Brain: A Review

The Impact of the Background Radiation on the Health

Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database

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