The Impact of the Background Radiation on the Health

Туруспекова, С Т; Tsoy, R.

doi:10.32014/2019.2519-1629.24

OF THE NATIONAL ACADEMY OF SCIENCES OF THE REPUBLIC OF KAZAKHST

2019

DOI: 10.32014/2019.2519-1629.24

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The Impact of the Background Radiation on the Health

С Т Туруспекова¹,

R. Tsoy²

Abstract: Abzhanov Arkhat, prof. (Boston, USA), Abelev S.K., prof. (Moscow, Russia), Aitkhozhina N.А., prof., academician (Kazakhstan) Akshulakov S.K., prof., academician (Kazakhstan) Alchinbayev М.K., prof., academician (Kazakhstan) Batpenov N.D., prof., corr. member (Kazakhstan) Berezin V.Ye., prof., corr. member. (Kazakhstan) Bersimbayev R.I., prof., academician (Kazakhstan) Berkinbaev S.F., prof. (Kazakhstan) Bisenbayev А.K., prof., academician (Kazakhstan) Bishimbayeva N.K., prof., academician (Kazakhstan) Botabeko… Show more

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Polymorphisms in the Genes of Reparations Among Employees of the Atomic Industry of Kazakhstan

Botbаeyev

Belkozhaev²,

Khanseitova³

et al. 2020

Series of Biological and Medical

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Single nucleotide polymorphisms (SNPs) are the most convenient marker and the widespread subject of polymorphism testing. To identify the presence or absence of the effects of chronic low-dose radiation on nuclear industry personnel, the occurrence of single-nucleotide substitutions at the polymorphic sites of the genes of the repair system 3 and 6 of the introns of the APC gene P53.11 gene, in positions -2549 of the VEGF gene, XPD gene rs313181 ( Lys751Gln) and rs25487 of the XRCC gene (Аrg399Gln) were compared. Analysis of allele frequencies and distribution of genotypes in the variable regions of the tested genes was performed by the method of polymerase chain reaction (PCR), followed by determination of restriction fragment length polymorphism (RFLP). When com-paring the frequencies of alleles and the distribution of genotypes between the second group of miners (11–20 years’ experience) and control, differences in the distribution of genotypes in the rs25487 XRCC plot (χ2 = 7.11, p = 0.028) were revealed. These differences satisfy the criterion p <0.05 and, accordingly, are statistically significant. Key words: polymorphism, genes, a nuclear industry.

show abstract

Polymorphisms in the Genes of Reparations Among Employees of the Atomic Industry of Kazakhstan

Botbаeyev

Belkozhaev²,

Khanseitova³

et al. 2020

Series of Biological and Medical

View full text Add to dashboard Cite

show abstract

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The Impact of the Background Radiation on the Health

Cited by 1 publication

References 34 publications

Polymorphisms in the Genes of Reparations Among Employees of the Atomic Industry of Kazakhstan

Polymorphisms in the Genes of Reparations Among Employees of the Atomic Industry of Kazakhstan

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