Association of polyunsaturated/saturated fatty acids to metabolic syndrome cardiovascular risk factors and lipoprotein (a) in hypertensive type 2 diabetic patients

Bennacer, Amira Fatma; Haffaf, Elmahdi; Kacimi, Ghouti; Oudjit, Brahim; Koceir, Elhadj Ahmed

doi:10.1684/abc.2017.1244

Cited by 10 publications

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“…Obesity as the major component of metabolic syndrome is still without an effective, non-invasive treatment free from adverse effects, with functional foods and nutraceuticals, including omega-3 fatty acids, proposed as effective treatment options [ 40 ]. EPA and DHA have been reviewed extensively for their effectiveness against metabolic syndrome [ 13 , 14 , 15 ]. Omega-3 and omega-6 fatty acids play vital roles in regulating metabolism as well as state of inflammation [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Diet interventions targeting these metabolic syndrome parameters would be a potential approach to decrease the risk of diabetes and cardiovascular disease in prostate cancer survivors treated with induced testosterone deficiency, and possibly slow down tumor progression. The health benefits of omega-3 fatty acids such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in metabolic syndrome and cardiovascular diseases have been reviewed [ 13 , 14 , 15 ]. Omega-3 fatty acids (EPA and DHA, 1.8 g/day for 26 weeks) decreased expression of genes associated with inflammation and atherogenesis-associated pathways [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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Attenuation of Metabolic Syndrome by EPA/DHA Ethyl Esters in Testosterone-Deficient Obese Rats

et al. 2018

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Inducing testosterone deficiency, as the standard treatment of prostate cancer, may cause metabolic disorders including insulin resistance, dyslipidemia, central obesity, cardiovascular diseases, and type 2 diabetes. This study measured responses to testosterone deficiency in high-carbohydrate, high-fat (H) diet-fed rats. We then tested whether eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) ethyl esters (Omacor) reversed these metabolic changes. Male Wistar rats (8–9 weeks old) were divided into eight groups with four groups fed corn starch and four groups fed H diet. For each diet, one group received diet only; one group was orchidectomized; one group was given leuprolide (gonadotrophin-releasing hormone agonist, 2 mg/kg every 4th week); and the last group was treated with leuprolide and their diet was supplemented with 3% Omacor for the last eight weeks. The protocol was for 16 weeks. Leuprolide worsened metabolic syndrome symptoms and cardiovascular function, and orchidectomy produced greater responses. In H fed leuprolide-treated rats, Omacor decreased systolic blood pressure and left ventricular diastolic stiffness, reduced infiltration of inflammatory cells and collagen deposition in the heart, and reduced lipid accumulation and inflammatory cell infiltration without improving liver damage. These results suggest that Omacor has potential to attenuate metabolic complications in prostate cancer patients with induced testosterone deprivation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Attenuation of Metabolic Syndrome by EPA/DHA Ethyl Esters in Testosterone-Deficient Obese Rats

et al. 2018

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“…Total plasma fatty acids are strongly associated with lipoprotein metabolism and various lipoprotein features, such as cholesterol and content of saturated species are related with cardiovascular health [7–9]. Despite existing evidence of the importance of lipoprotein fatty acid composition for the metabolism and functionality of some of these particles [10], differences in molecular species found in different lipoproteins have hardly been studied.…”

Section: Introductionmentioning

confidence: 99%

Phospholipids in lipoproteins: compositional differences across VLDL, LDL, and HDL in pregnant women

et al. 2019

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ObjectiveThe aim of this study was to analyse the differences in the phospholipid composition of very low density (VLDL), low density (LDL) and high density lipoprotein (HDL) monolayers in pregnant lean and obese women.MethodsLDL, HDL, and VLDL were isolated from plasma samples of 10 lean and 10 obese pregnant women, and their species composition of phosphatidylcholines (PC) and sphingomyelins (SM) was analysed by liquid-chromatography tandem mass-spectrometry. Wilcoxon-Mann-Whitney U test and principal component analysis (PCA) were used to investigate if metabolite profiles differed between the lean/obese group and between lipoprotein species.ResultsNo significant differences have been found in the metabolite levels between obese and non-obese pregnant women. The PCA components 1 and 2 separated between LDL, HDL, and VLDL but not between normal weight and obese women. Twelve SM and one PCae were more abundant in LDL than in VLDL. In contrast, four acyl-alkyl-PC and two diacyl-PC were significantly higher in HDL compared to LDL. VLDL and HDL differed in three SM, seven acyl-alkyl-PC and one diacyl-PC (higher values in HDL) and 13 SM (higher in VLDL). We also found associations of some phospholipid species with HDL and LDL cholesterol.ConclusionIn pregnant women phospholipid composition differs significantly in HDL, LDL and VLDL, similar to previous findings in men and non-pregnant women. Obese and lean pregnant women showed no significant differences in their lipoprotein associated metabolite profile.Electronic supplementary materialThe online version of this article (10.1186/s12944-019-0957-z) contains supplementary material, which is available to authorized users.

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“…In G. impressa, palmitic acid represents about 50% of the total fatty acid content of this insect. Saturated fatty acids are excellent energy nutrients, but a high level of saturated fatty acids in food may be undesirable because of the link between saturated fatty acids and atherosclerosis [36]. This same species contains elaidic acid (0.62%) which is the trans isomer of oleic acid.…”

Section: Discussionmentioning

confidence: 99%

Nutritional Potential of Two Insect Species Consumed in Togo: Gnathocera trivittata (Swederus, 1787) and Gnathocera impressa (Olivier, 1789)

Badanaro

Tété‐Bénissan

Amouzou

2021

EJNFS

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Aims: The objective of this study is to determine the nutritional values of Gnathocera trivittata and Gnathocera impressa in order to promote their consumption for food security. Place and Duration of Study: Samples of G. trivittata and G. impressa were caught in Togo in the three following localities: Kparatao (8°57'151"N; 1°11'838"E), Kpéwa (9°16'978"N; 1°14'149"E) and Soudou (9°21'604"N; 1°21'348"E), between September and December 2013. Methodology: The contents of ash, protein, vitamins as well as lipids were determined. Fiber content was obtained. Minerals were analyzed by atomic absorption spectrophotometry and colorimetry. Fatty acid composition of the lipids was determined by gas chromatography and the amino acid composition was obtained by separation of the individual amino acids using the Biochrom 30+ amino acid analyzer. Results: The results reveal that the average protein content of the insects studied ranged from 59.36 to 61.63%. Average lipid levels ranged from 9.09 to 9.86%. They contain all the essential fatty and amino acids. Their average fiber content fluctuates between 8.35 and 10.05%. Regarding the composition of micronutrients, the species studied are very rich in minerals and vitamins. The ratios of minerals, fatty acids and essential amino acids are balanced. Conclusion: Given the nutritional potentials of the insects studied, they can contribute significantly to the fight against protein-energy and micronutrient malnutrition in Togo.

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Association of polyunsaturated/saturated fatty acids to metabolic syndrome cardiovascular risk factors and lipoprotein (a) in hypertensive type 2 diabetic patients

Cited by 10 publications

References 0 publications

Attenuation of Metabolic Syndrome by EPA/DHA Ethyl Esters in Testosterone-Deficient Obese Rats

Attenuation of Metabolic Syndrome by EPA/DHA Ethyl Esters in Testosterone-Deficient Obese Rats

Phospholipids in lipoproteins: compositional differences across VLDL, LDL, and HDL in pregnant women

Nutritional Potential of Two Insect Species Consumed in Togo: Gnathocera trivittata (Swederus, 1787) and Gnathocera impressa (Olivier, 1789)

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