Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility

Rodríguez, Anaís García; Casa, Moises de la; Johnston, Stephen D.; Gosálvez, Jaime; Roy, Rosa

doi:10.1111/ahg.12286

Cited by 24 publications

(27 citation statements)

References 30 publications

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“…That means that patients with sperm motility impairment and disrupted morphology of the sperm cells are in high risk of oxidative stress. The results of this study concordant with findings of other authors state that oxidative stress is caused by reduction of antioxidant enzymes activity due the polymorphisms of antioxidant systems genes and it affects the spermatozoa worsening their fertility [15,21].…”

Section: Discussionsupporting

confidence: 92%

“…In meta analysis of Safarinjad et al (2012) it was noted that only two studies were carried out before 2012 to reveal the association GSTP1 polymorphisms with male infertility [15]. In Europe population it was identified an association between GSTP1 polymorphisms and abnormalities in sperm parameters in infertile men in Spain [21]. It is necessary to note that few studies have been carried out to clarify the association of GSTP1 polymorphism with risk of pathospermia but these relationships are still controversial [16,22].…”

Section: Discussionmentioning

confidence: 99%

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Influence of GSTP1 gene polymorhism on decreased semen quality

et al. 2019

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Background ― Genetic polymorphisms analysis of metabolic and antioxidant systems pathway genes are associated with male infertility is the most perspective and developed field in andrology. Purpose ― the aim of the research is to reveal the association of the glutathione S-transferase gene GSTP1 polymorphism C/T (rs1138272) with risk of pathospermia in Russian men in Moscow region. Material and Methods ― Case control study was conducted on 68 fertile men and 70 infertile men with various forms of pathospermia. Sperm analysis was performed according to WHO guidelines (WHO, 2010). DNA was extracted from peripheral blood leukocytes. Genotyping of the GSTP1 gene polymorphisms was carried out by generated amplicons from melting curve analysis after real time PCR. Results ― statistically significant association of polymorphism GSTP1 C/T (Ala/Val; rs1138272) with asthenozoospermia (χ2=8.58, p=0.003) and teratospermia (χ2=6.81, p=0.009) risk was found. The frequencies of homozygous and heterozygous carries (CT+TT genotypes) for polymorphic locus GSTP1 gene (rs1138272) are 3 times higher for men with disturbance of motility of spermatozoa and 2.5 times higher for men with abnormalities in morphology of spermatozoa, then for men with normozoospermia. Conclusion ― The GSTP1 C>T polymorphism (rs1138272) associated with risk of teratospermia and asthenozoospermia in male of reproductive age.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Influence of GSTP1 gene polymorhism on decreased semen quality

et al. 2019

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“…It becomes even more difficult to correct the pathospermia when no visible reasons for its occurrence can be found, and doctors are forced to state idiopathic infertility [3,7]. Currently, oxidative stress is considered to be one of the leading causes of male infertility [3,5] Oxidative stress is an imbalance between the level of reactive oxygen species (ROS) and the ability of the human biochemical system to block reactive oxygen species [2,3]. In case of a violation of antioxidant protection in a man, the cell membrane of the sperm cell becomes damaged, DNA fragmentation and apoptosis of germ cells occur [1,2].…”

Section: российский университет дружбы народов москва российская феmentioning

confidence: 99%

“…In case of a violation of antioxidant protection in a man, the cell membrane of the sperm cell becomes damaged, DNA fragmentation and apoptosis of germ cells occur [1,2]. It causes a violation of quantitative and qualitative indicators of the sperm, up to the total death of male gametes [3,5].…”

Section: российский университет дружбы народов москва российская феmentioning

confidence: 99%

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The frequency of polymorphism –262 C>T CAT gene of infertile men in the moscow region

Myandina¹,

Кульченко²,

Alhejoj³

2019

Medical news of the North Caucasus

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The effects of the genetic polymorphisms of antioxidant enzymes on susceptibility to papillary thyroid carcinoma

et al. 2020

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Several lines of evidences have indicated that inflammation play an important role in the carcinogenesis. During the inflammatory processes, free radical species are produced from oxidative stress. In normal conditions, enzymatic and nonenzymatic antioxidants remove these products. Manganese superoxide dismutase (MnSOD), glutathione peroxidase‐1 (GPx‐1), and catalase (CAT) are three important enzymes. Therefore, this study aimed to evaluate the effects of MnSOD (SOD2), GPX‐1, and CAT genetic polymorphisms on papillary thyroid carcinoma (PTC) susceptibility. A total of 134 patients with PTC and 151 healthy controls were recruited to participate in this study. All samples were genotyped for SOD2 rs4880, GPX1 1050450, and CAT rs7943316 polymorphisms by polymerase chain reaction‐restriction fragment length polymorphism method. The frequencies of the rs1050450, rs4880, and rs7943316 alleles and genotypes were not different between PTC patients and controls. However, the TC genotype of SOD2 rs4880 polymorphism was significantly higher in males compared to that in females in PTC patients (odds ratio [OR], 3.9 [95% CI, 1.5–11], p = .007). The rs4880 polymorphism was also associated with higher stages (III‐IV) of PTC in dominant model. No significant correlation was found between GPX1‐rs1050450 and CAT‐rs7943316 polymorphisms and demographic, clinical, and pathological features of the disease. The SOD2 rs4880CT genotype was more frequent in males with PTC and patients with higher stages (III–IV) of disease (OR, 2.9 [95% CI, 1.1–7.7], p = .04). However, no significant association was found between GPX1‐rs1050450 and CAT‐rs7943316 variants and PTC or its demographic, clinical, and pathological features.

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Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility

Abstract: Our results suggest that the CAT SNP C-262T is potentially associated with an increased risk of male infertility.

Cited by 24 publications

References 30 publications

Influence of GSTP1 gene polymorhism on decreased semen quality

Influence of GSTP1 gene polymorhism on decreased semen quality

The frequency of polymorphism –262 C>T CAT gene of infertile men in the moscow region

The effects of the genetic polymorphisms of antioxidant enzymes on susceptibility to papillary thyroid carcinoma

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