ПоЛИморФИЗм g-105a ГЕНа seps1 И мУЖСКоЕ БЕСПЛодИЕ Г. И. мяндина, Н. Г. Кульченко, Х. альхеджой российский университет дружбы народов, москва, российская Федерация Reproductive disorders in men are the cause of infertility of 30-40 % of infertile couples. The genetic factors play a great role in male infertility as they are detected in 15-30 % of men. The distributions of polymorphic variants of candidate genes relevant to male fertility in different populations are of great interest to explain the male idiopathic infertility. The aim of this study was to explore the association of the SEPS1 gene polymorphism G-105A (rs28665122) with pathospermia in infertile men in Moscow region. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to detect SEPS1 G-105A polymorphism in 26 cases and 24 controls. The results showed that the frequency of the minor allele A of geneSEPS1 is higher in men with pathospermia than in the control group of fertile men. Conclusion: The SEPS1 gene polymorphismG-105A is associated with idiopathic infertility in men with pathospermia and can be used to screen idiopathic infertility in men.
Background ― Genetic polymorphisms analysis of metabolic and antioxidant systems pathway genes are associated with male infertility is the most perspective and developed field in andrology. Purpose ― the aim of the research is to reveal the association of the glutathione S-transferase gene GSTP1 polymorphism C/T (rs1138272) with risk of pathospermia in Russian men in Moscow region. Material and Methods ― Case control study was conducted on 68 fertile men and 70 infertile men with various forms of pathospermia. Sperm analysis was performed according to WHO guidelines (WHO, 2010). DNA was extracted from peripheral blood leukocytes. Genotyping of the GSTP1 gene polymorphisms was carried out by generated amplicons from melting curve analysis after real time PCR. Results ― statistically significant association of polymorphism GSTP1 C/T (Ala/Val; rs1138272) with asthenozoospermia (χ2=8.58, p=0.003) and teratospermia (χ2=6.81, p=0.009) risk was found. The frequencies of homozygous and heterozygous carries (CT+TT genotypes) for polymorphic locus GSTP1 gene (rs1138272) are 3 times higher for men with disturbance of motility of spermatozoa and 2.5 times higher for men with abnormalities in morphology of spermatozoa, then for men with normozoospermia. Conclusion ― The GSTP1 C>T polymorphism (rs1138272) associated with risk of teratospermia and asthenozoospermia in male of reproductive age.
na R. [et al.] Oxidative stress-mediated alterations on sperm parameters in male Wistar rats exposed to 3G mobile phone radiation
The number of patients with hypertrophic skin scars is increasing every year. Scar tissue is formed as a result of healing of a wound defect. Therefore, in order to develop optimal methods for the treatment of scarring skin changes, it is necessary to understand the pathogenesis of the wound process. The purpose of this work was to analyze the literature data on the effectiveness of the use of plateletrich plasma (PRP) in the treatment of scarring that appeared in patients with acne. PRP contains epidermis growth factor, vascular endothelial growth factor, which help accelerate the healing of skin wounds. Conclusion: PRP can be successfully used in the treatment of atrophic scars on the skin after acne. Therefore, this method can be used both in monotherapy and in combination with surgical methods of treatment.
The number of patients with hypertrophic skin scars is increasing every year. Scar tissue is formed as a result of healing of a wound defect. Therefore, in order to develop optimal methods for the treatment of scarring skin changes, it is necessary to understand the pathogenesis of the wound process. The purpose of this work was to analyze the literature data on the effectiveness of the use of plateletrich plasma (PRP) in the treatment of scarring that appeared in patients with acne. PRP contains epidermis growth factor, vascular endothelial growth factor, which help accelerate the healing of skin wounds. Conclusion: PRP can be successfully used in the treatment of atrophic scars on the skin after acne. Therefore, this method can be used both in monotherapy and in combination with surgical methods of treatment.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.