The effects of the genetic polymorphisms of antioxidant enzymes on susceptibility to papillary thyroid carcinoma

Salimi, Saeedeh; Harati‐Sadegh, Mahdiyeh; Eskandari, Moein; Heidari, Zahra

doi:10.1002/iub.2246

Cited by 12 publications

(5 citation statements)

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“…Recent studies demonstrated that reduced expression of SOD2 increased the incidence of cancer, and it has been known that reduced expression levels of SOD2 might also result in increased DNA damage due to lower protection against ROS, and that the XPD mutant genotype had a lower capacity for repair than the wild type [23,30]. Consequently, these genotypes together can lead to an increase in cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Association between superoxide dismutase 2, glutathione peroxidase 1, xeroderma pigmentosum group d gene variations, and head and neck squamous cell cancer susceptibility

Kose

Merve

Cömert

et al. 2022

ARCH BIOL SCI BELGRA

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As oxidative stress is implicated in the pathogenesis of head and neck squamous cell cancer (HNSCC), the functions of antioxidant enzyme systems and DNA repair proteins are critical in the development of cancer. To investigate the role of genetic polymorphisms of the antioxidant superoxide dismutase 2 (SOD2) Val16Ala, glutathione peroxidase 1 (GPX1) Pro198Leu, and the DNA repair Xeroderma Pigmentosum Group D (XPD) Lys751Gln genes under exogenous risk factors, including smoking and alcohol consumption, in HNSCC carcinogenesis, we conducted a case-control study on 139 unrelated cases and 265 non-cancer controls. Polymorphisms were analyzed in additive, dominant and recessive genetic models, individually and in an interaction model. Carriers of the T allele of SOD2 were associated with an increased risk for HNSCC in the overall subgroups of males and smokers; similarly, the T allele of GPX1 was associated with elevated risk in the overall and smoker subgroup. A 12.47-fold increased risk was observed for the carriers of GPX1 TT, SOD2 CT and XPD CC genotypes for HNSCC. This is the first study presenting the potential roles of SOD2, GPX1 and XPD polymorphisms in interaction and under three genetic models in the development of HNSCC. The results suggest that these polymorphisms slightly modify the risk in HNSCC development individually but are significantly higher when they functioned and were evaluated together.

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Section: Discussionmentioning

confidence: 99%

Association between superoxide dismutase 2, glutathione peroxidase 1, xeroderma pigmentosum group d gene variations, and head and neck squamous cell cancer susceptibility

Kose

Merve

Cömert

et al. 2022

ARCH BIOL SCI BELGRA

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“…A protective effect of the Leu variant was found in the North Macedonia population, where the carriers of this variant allele had a lower risk of prostate cancer than wild-type individuals [88]. No associations were found between the rs1050450 polymorphism and other cancers, such as endometrial cancer in Polish women [71], papillary thyroid carcinoma in the Iran population [92], colorectal adenomas and colorectal cancer in Norwegian patients [64], and laryngeal cancer survival patients in the Poland population [83].…”

Section: Selenoproteins and Their Polymorphismsmentioning

confidence: 99%

Current Understanding of Human Polymorphism in Selenoprotein Genes: A Review of Its Significance as a Risk Biomarker

Ferreira,

Carvalho,

Coelho

et al. 2024

IJMS

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Selenium has been proven to influence several biological functions, showing to be an essential micronutrient. The functional studies demonstrated the benefits of a balanced selenium diet and how its deficiency is associated with diverse diseases, especially cancer and viral diseases. Selenium is an antioxidant, protecting the cells from damage, enhancing the immune system response, preventing cardiovascular diseases, and decreasing inflammation. Selenium can be found in its inorganic and organic forms, and its main form in the cells is the selenocysteine incorporated into selenoproteins. Twenty-five selenoproteins are currently known in the human genome: glutathione peroxidases, iodothyronine deiodinases, thioredoxin reductases, selenophosphate synthetase, and other selenoproteins. These proteins lead to the transport of selenium in the tissues, protect against oxidative damage, contribute to the stress of the endoplasmic reticulum, and control inflammation. Due to these functions, there has been growing interest in the influence of polymorphisms in selenoproteins in the last two decades. Selenoproteins’ gene polymorphisms may influence protein structure and selenium concentration in plasma and its absorption and even impact the development and progression of certain diseases. This review aims to elucidate the role of selenoproteins and understand how their gene polymorphisms can influence the balance of physiological conditions. In this polymorphism review, we focused on the PubMed database, with only articles published in English between 2003 and 2023. The keywords used were “selenoprotein” and “polymorphism”. Articles that did not approach the theme subject were excluded. Selenium and selenoproteins still have a long way to go in molecular studies, and several works demonstrated the importance of their polymorphisms as a risk biomarker for some diseases, especially cardiovascular and thyroid diseases, diabetes, and cancer.

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“…There are several studies on the relationship between Catalase polymorphisms and the risk of various cancers [31], but there are very few studies on the correlation between the CAT-rs7943316 polymorphism and cancer risk. Several studies have proved that rs7943316 polymorphisms are unassociated with a risk of papillary thyroid carcinoma [32] or hepatocellular carcinoma risk [33]. Numerous researchers have submitted that Catalase polymorphisms may be linked with the possibility of many cancers such as cervical cancer, prostate cancer, pancreatic cancer, and colorectal cancer [7,[34][35][36].…”

Section: Distribution Of Cat (Rs7943316) Polymorphism Genotype With A...mentioning

confidence: 99%

Study of promotor -21 A/T polymorphism of catalase CAT (rs7943316) gene in patients with breast cancer

Abdulabbas

Al-Mawlah

Shaheed³

et al. 2022

Preprint

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Oxidative stress is implicated in many forms of cancer, and catalase is one of the most critical enzymes involved in the organic body's defensive mechanism against stress on antioxidation. Catalase shows a vital role in the body's primary defense versus oxidative stress. Several studies have indicated that CAT gene polymorphism plays an essential role in the pathogenesis of cancer. This study aimed to recognize the influence of the CAT (rs7943316) gene polymorphism on breast cancer progress in patients using a collection of blood samples from each subject. After the extraction of genomic DNA, the SNP rs7943316 analysis was performed using PCR, RFLP, and electrophoresis on agarose. finally visualized under UV light and analyzed with SPSS software (version 23). This study revealed that the higher genotype in the control subjects was AT genotype 19 (63.3%), followed by TT genotype 11 (36.7%), and AA genotype (0%). In the BC group, AT genotype was the higher 39 (55.7%), followed by TT genotype 24 (34.3%), and AA genotype 7 (10.0%). Individual carriers of the A/T and T/T type of genotype were less expected to develop BC [OR = 0.135, 95% CI = 0.0073-2.4882, P value = 0.178] and [OR = 0.1420, 95% CI = 0.0075-2.70, P value = 0.1943], respectively. In addition, there are no significant differences in frequencies of the T allele of the CAT gene (rs7943316) between breast cancer patients and control groups [OR = 0.67, 95% CI = 0.4002-1.4459, P value = 0.4039]. In brief, the current study’s results suggest no correlation between rs7943316 polymorphisms of CAT genes and the development of BC; the genotypes AA, AT, and TT have no potential risk for breast cancer in patient women.

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The effects of the genetic polymorphisms of antioxidant enzymes on susceptibility to papillary thyroid carcinoma

Cited by 12 publications

References 50 publications

Association between superoxide dismutase 2, glutathione peroxidase 1, xeroderma pigmentosum group d gene variations, and head and neck squamous cell cancer susceptibility

Association between superoxide dismutase 2, glutathione peroxidase 1, xeroderma pigmentosum group d gene variations, and head and neck squamous cell cancer susceptibility

Current Understanding of Human Polymorphism in Selenoprotein Genes: A Review of Its Significance as a Risk Biomarker

Study of promotor -21 A/T polymorphism of catalase CAT (rs7943316) gene in patients with breast cancer

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