Association of polymorphisms in estrogen receptors (ESR1 and ESR2) with male infertility: a meta-analysis and systematic review

Abstract

This meta-analysis suggested that polymorphisms in the genes of ERs (ESR1 and ESR2) may have differential roles in the predisposition to male infertility according to the different ethnic backgrounds. Further well-designed and unbiased studies with larger sample size and diverse ethnic backgrounds should be conducted to verify our findings.

Androgen receptor (AR)-CAG trinucleotide repeat length and idiopathic male infertility: a case-control trial and a meta-analysis

“…Male infertility is an important problem and one of the causes of couples' inability to bear children (Ge et al, 2014[ 19 ]). It is estimated that there are about 30 million infertile men in the world (Agarwal et al, 2015[ 1 ]) and 15-30 % of causes of male infertility refer to genetic factors (Talebi et al, 2018[ 57 ]).…”

“…Infertility is a major health problem with associations to both genetic and environmental factors, affecting one-sixth of couples worldwide (Batiha et al, 2018[ 5 ]; Ge et al, 2014[ 19 ]). Approximately 50 % of infertility cases are attributed to male factors (Zorrilla and Yatsenko, 2013[ 67 ]).…”

Paternal Uniparental Disomy of Chromosome 14 with Hypospadias

“…The gene product contains an N-terminal DNA-binding domain and a C-terminal ligand-binding domain and localizes to the nucleus, cytoplasm, and mitochondria [Lucas et al, 2008;Scariano et al, 2008;Tsezou et al, 2008]. ESR2 is one of the genes linked to spermatogenic failure and male infertility [Ge et al, 2014]. In addition, precocious puberty occurs in matUPD14 patients, which could result from an abnormality in ESR2 .…”

The physiology of male reproduction: Impact of drugs and their abuse on male fertility

“…Ge et al. (2014) summarised the differential association of polymorphisms in oestrogen receptors ( PvuII, XbaI, RsaI and AluI ) with male infertility in their meta‐analysis and systematic review. Overall, it was found that the PvuII polymorphism in ESR1 was associated with significant decrease in the risk of male infertility.…”

“…It can thus be inferred from the study of Ge et al. (2014) that polymorphisms of oestrogen receptor genes may have differential roles in the predisposition to male infertility according to the different ethnic background.…”