The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Ajayi, Ayodeji Folorunsho; Akhigbe, R.E.

doi:10.1111/and.13672

Cited by 51 publications

(32 citation statements)

References 269 publications

(355 reference statements)

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“…The need to increase libido, potency and sexual pleasure might be the reason young adults engage in illicit drug use. Recreational drug use has been implicated in the aetiopathogenesis of infertility including male fertility (Ajayi & Akhigbe, 2020a, 2020b, 2020cKatz & Mazer, 2009;Turek et al, 1995). This study assessed the effect of Rohypnol, a commonly abused drug, on sexual behaviour in animal model.…”

Section: Discussionmentioning

confidence: 99%

“…Co-ordination of the hypothalamic-pituitary-testicular axis is important for sexual activity. It influences male reproductive function as well as production of testosterone and prolactin (Ajayi & Akhigbe, 2020b;Corradi et al, 2016). Hypothalamic secretion of gonadotropin-releasing hormones (GnRH) stimulates the biosynthesis of luteinising hormone (LH) and follicle-stimulating hormone (FSH) which are vital in maintaining optimal production of testosterone (Ajayi & Akhigbe, 2020b;Corradi et al, 2016).…”

mentioning

confidence: 99%

“…Optimal concentrations of circulatory and intra-testicular testosterone as well as minimal level of prolactin are essential for sexual urge and performance (Ajayi & Akhigbe, 2020b). When a sufficient circulatory level of testosterone is reached, a negative feedback mechanism is triggered o decrease the secretions of GnRH, LH, and FSH (Ajayi & Akhigbe, 2020b;Corradi et al, 2016;Dhillo et al, 2005).…”

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confidence: 99%

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Rohypnol‐induced sexual dysfunction is via suppression of hypothalamic‐pituitary‐testicular axis: An experimental study in rats

2020

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Achieving sexual satisfaction is the reason so many men have become drug users and the desire to be in control during sexual act accounts for the increase usage of several substances by men. Sexual activity is no doubt a part of reproductive function, and it is essential for the maintenance of fertility which has recently been a challenge due to the increase in infertility cases from the male factor (Nikpoor et al., 2004; Sasikumar & Dakshayani, 2013). Drugs, especially substances of abuse, impair male reproduction, including sexual performance, either by interrupting hormonal functions or through the

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Rohypnol‐induced sexual dysfunction is via suppression of hypothalamic‐pituitary‐testicular axis: An experimental study in rats

2020

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“…Human and animal studies have implicated several drugs, including drugs that are commonly abused such as codeine, in male infertility [ 27 ]. Although, our previous studies reported that codeine impaired male fertility, testicular and sperm integrity with their functions [ 4 , 5 , 7 ] via oxidative damage and caspase 3-mediated apoptosis, there are still some shortcomings.…”

Section: Introductionmentioning

confidence: 99%

In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway

Ajayi

Akhigbe

2020

Heliyon

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Several studies have implicated codeine use in the aetiopathogenesis of male infertility. The purpose of this study was to investigate the role of HER2, Ki67, oestrogen and p53/Bcl-2 signaling pathways and the possible outcome of codeine cessation on codeine-induced reproductive toxicity. Thirty adult male Wistar rats of comparable ages and weights were randomly allocated into 5 groups. The control animals received distilled water per os (p.o), while animals in the low-dose (LDC) and high dose (HDC) codeine-treated groups received 2 and 5 mg/kg/day of codeine respectively p.o for 6 weeks. The animals in the low-dose codeine recovery (LDC-R) and high-dose codeine recovery (HDC-R) groups received treatment as LDC and HDC respectively followed by another drug-free six weeks, recovery period. Cessation of codeine exposure led to a partial reversal of codeine-induced poor sperm quality, reduced litter size and weight, increased oxidative testicular injury, testicular apoptosis, and testicular DNA damage caused by codeine administration. Codeine-induced gonado-spermotoxicity was associated with a reduction of circulatory testosterone, suppression of testicular HER2, Ki67, and Bcl-2 expression, down-regulation of oestrogen signaling, and upregulation of testicular caspase 3 activities and p53 signaling pathway. Conclusion: Upregulation of oestrogen signaling associated with enhanced testicular HER2 and Ki67 expression during the recovery period is seemingly beneficial in protecting against codeine-related testicular injury and infertility.

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“…GABA receptors have been identified not only in the central nervous system, but also in many non‐neuronal peripheral tissues (Ajayi & Akhigbe, 2020; Kaewman et al., 2018; Taniyama et al., 1983; Teng et al., 2013). Their presence was confirmed in, among others, structures of the male and female reproductive system, including testes, epididymis, vas deferens, ovaries and oviducts (Kanbara et al., 2005).…”

Section: Introductionmentioning

confidence: 99%

Long‐term stiripentol administration, an anticonvulsant drug, does not impair sperm parameters in rats

et al. 2021

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In this study, we investigated the influence of long‐term administration of stiripentol on sex hormones and semen quality in young Wistar rats. Investigated animals received for 6 months either stiripentol or saline solution. After one month, stiripentol increased temporarily serum level of testosterone (p < 0.05) and FSH (p < 0.01). However, after 6 months levels of testosterone, FSH, LH, prolactin and SHBG were comparable in both groups. After 6 months, semen analysis did not reveal differences in sperm concentration, total sperm count and sperm motility between groups. However, stiripentol increased the rate of head defect (p < 0.001) and midpiece abnormalities (p < 0.05). Flow cytometry revealed higher percentage of live cells without lipid peroxidation (p < 0.00001) and higher percentage of live spermatozoa with intact acrosomes (p < 0.000001) in rats receiving stiripentol. There was no significant difference between groups in sperm mitochondrial activity and DNA fragmentation index. However, percentage of high DNA stainability cells was increased in stiripentol group (p < 0.001). The data showed that stiripentol does not cause obvious disturbances in young rat's semen. Detected changes in semen morphology and chromatin structure need further explanation, and their influence on rat's fertility should be evaluated.

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The physiology of male reproduction: Impact of drugs and their abuse on male fertility

Cited by 51 publications

References 269 publications

Rohypnol‐induced sexual dysfunction is via suppression of hypothalamic‐pituitary‐testicular axis: An experimental study in rats

Rohypnol‐induced sexual dysfunction is via suppression of hypothalamic‐pituitary‐testicular axis: An experimental study in rats

In vivo exposure to codeine induces reproductive toxicity: role of HER2 and p53/Bcl-2 signaling pathway

Long‐term stiripentol administration, an anticonvulsant drug, does not impair sperm parameters in rats

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