Association of Polymorphic Markers of the Antioxidant Enzyme Genes with Diabetic Polyneuropathy in Type 1 Diabetes Mellitus

Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease

“…In T1DM patients, the frequency of the Pro/Leu genotype was higher and Pro/Pro genotype lower in patients with diabetic polyneuropathy compared to T1DM patients without polyneuropathy, although the difference was not statistically significant (Zotova et al, 2004). Frequencies of GPx1 genotypes between those with and without diabetic neuropathy were not significantly different (Chistiakov et al, 2006).…”

“…No association between catalase C-262T genotypes and the risk of T1DM was found (Pask et al, 2006). In contrast, two studies reported that T1DM patients with the catalase C allele had an increased risk of developing diabetic neuropathy (Chistiakov et al, 2006;Zotova et al, 2004).…”

“…GPx has a single seleno-cysteine residue, which is essential for activity and is present in the five isoforms so far identified (Arthur, 2000;El-Far et al, 2005;Hamanishi et al, 2004). GPx1 is cytosolic (cGPx) and is produced in all tissues, although mainly in erythrocytes, kidney and liver (Zotova et al, 2004). GPx2 is also cytosolic and found in the liver and the colon.…”

“…Three studies investigated the relationship between T1DM and catalase C-262T SNP genotypes (Chistiakov et al, 2006;Pask et al, 2006;Zotova et al, 2004), one involved two groups: one consisting of 1642 individuals, and the second was a case-control study involving 7460 participants of which 3530 had T1DM. No association between catalase C-262T genotypes and the risk of T1DM was found (Pask et al, 2006).…”

Diabetic Microangiopathy - Etiopathogenesis, New Possibilities in Diagnostics and Management

“…Some studies claimed higher risk of DM 2 in GST T1 null and T1 null / M1 null genotype (Hori et al, 2007), according to another study, in contrary, the presence of GST M1 allele was risk factor for development of DM 1 and M1 null allele was regarded as a protective (Bekris et al, 2005). Some authors did not find any significant relation between GST polymorphisms and diabetic neuropathy (Zotova et al, 2004). GST T1 null genotype was associated with chronic kidney disease in diabetic as well as non-diabetic subjects disregarding GST M1 genotype (Datta et al, 2010).…”