Diabetic Microangiopathy - Etiopathogenesis, New Possibilities in Diagnostics and Management

Vojtková, Jarmila; Ciljakova, Miriam; Bánovčin, Peter

doi:10.5772/31103

Cited by 5 publications

(9 citation statements)

References 83 publications

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“…Autonomic neuropathy may cause symptoms in various organ systems. Both generalized and organ-specific exams are available for better diagnostics (Vojtková et al, 2012). To detect microvascular damage to the autonomic nervous system, heart rate variability is studied by spectral and frequency analysis using the Ewing's battery of cardiovascular tests.…”

Section: Methods For Study Of Microvascular Functionmentioning

confidence: 99%

“…The clinical stages of diabetic microangiopathy affecting different tissues have been reviewed (Vojtková et al, 2012).…”

Section: Macrovascular Diseasementioning

confidence: 99%

“…Persistent hyperglycemia leads to overactivation of multiple pathways, oxidative stress, and decreased vasodilation. Increased ECM production, BM thickening, and enhanced vascular permeability damage the cellular structure and function (Vojtková et al, 2012). The thickening of the BM remains one of the most common structural modification in diabetes.…”

Section: Shared Characteristics and Unique Features Of Microvascular mentioning

confidence: 99%

“…In the kidney, glomerular, tubular, and mesangial cell expansion is seen with hyalinization of the connective tissue between the glomerular capillaries. Chronic kidney disease may finally lead to end stage renal disease and loss of life (Vojtková et al, 2012).…”

Section: Shared Characteristics and Unique Features Of Microvascular mentioning

confidence: 99%

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Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Gupta

Bhatnagar

2015

OMICS: A Journal of Integrative Biology

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Vasoregression is a common phenomenon underlying physiological vessel development as well as pathological microvascular diseases leading to peripheral neuropathy, nephropathy, and vascular oculopathies. In this review, we describe the hallmarks and pathways of vasoregression. We argue here that there is a parallel between characteristic features of vasoregression in the ocular microvessels and atherosclerosis in the larger vessels. Shared molecular pathways and molecular effectors in the two conditions are outlined, thus highlighting the possible systemic causes of local vascular diseases. Our review gives us a system-wide insight into factors leading to multiple synchronous vascular diseases. Because shared molecular pathways might usefully address the diagnostic and therapeutic needs of multiple common complex diseases, the literature analysis presented here is of broad interest to readership in integrative biology, rational drug development and systems medicine.

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Section: Methods For Study Of Microvascular Functionmentioning

confidence: 99%

“…The clinical stages of diabetic microangiopathy affecting different tissues have been reviewed (Vojtková et al, 2012).…”

Section: Macrovascular Diseasementioning

confidence: 99%

Section: Shared Characteristics and Unique Features Of Microvascular mentioning

confidence: 99%

Section: Shared Characteristics and Unique Features Of Microvascular mentioning

confidence: 99%

See 2 more Smart Citations

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Gupta

Bhatnagar

2015

OMICS: A Journal of Integrative Biology

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“…The microangiopathies share common pathophysiological, metabolic and ischaemic mechanisms that are triggered by hyperglycaemia 1. It is therefore expected that various diabetic complications may coexist.…”

Section: Introductionmentioning

confidence: 99%

Retinal sensitivity changes associated with diabetic neuropathy in the absence of diabetic retinopathy

et al. 2017

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Morphometric Analysis of Connective Tissue Sheaths of Sural Nerve in Diabetic and Nondiabetic Patients

Kundalić

Ugrenović

Jovanović

et al. 2014

BioMed Research International

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One of the most common complications of diabetes mellitus is diabetic neuropathy. It may be provoked by metabolic and/or vascular factors, and depending on duration of disease, various layers of nerve may be affected. Our aim was to investigate influence of diabetes on the epineurial, perineurial, and endoneurial connective tissue sheaths. The study included 15 samples of sural nerve divided into three groups: diabetic group, peripheral vascular disease group, and control group. After morphological analysis, morphometric parameters were determined for each case using ImageJ software. Compared to the control group, the diabetic cases had significantly higher perineurial index (P < 0.05) and endoneurial connective tissue percentage (P < 0.01). The diabetic group showed significantly higher epineurial area (P < 0.01), as well as percentage of endoneurial connective tissue (P < 0.01), in relation to the peripheral vascular disease group. It is obvious that hyperglycemia and ischemia present in diabetes lead to substantial changes in connective tissue sheaths of nerve, particularly in peri- and endoneurium. Perineurial thickening and significant endoneurial fibrosis may impair the balance of endoneurial homeostasis and regenerative ability of the nerve fibers. Future investigations should focus on studying the components of extracellular matrix of connective tissue sheaths in diabetic nerves.

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Diabetic Microangiopathy - Etiopathogenesis, New Possibilities in Diagnostics and Management

Cited by 5 publications

References 83 publications

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Retinal sensitivity changes associated with diabetic neuropathy in the absence of diabetic retinopathy

Morphometric Analysis of Connective Tissue Sheaths of Sural Nerve in Diabetic and Nondiabetic Patients

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