Association of periodontitis with persistent, pro‐atherogenic antibody responses

Buhlin, Kåre; Holmer, Jacob; Gustafsson, Anders; Hörkkö, Sohvi; Pockley, A. Graham; Johansson, Anders; Paju, Susanna; Klinge, Björn; Pussinen, Pirkko J.

doi:10.1111/jcpe.12456

Cited by 25 publications

(26 citation statements)

References 46 publications

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“…Forty‐nine patients (27 males and 22 females, aged 43 to 72 years; mean age: 55.1 ± 7.1 years) with severe periodontitis and 39 randomly selected healthy controls (18 males and 21 females, aged 40 to 63 years; mean age: 52.6 ± 7.1 years) were examined 18 , 19 . The study was approved by Regional Ethics Committee, Karolinska Institute, Huddinge, Sweden, and conducted in accordance with the Helsinki Declaration of 1975, as revised in 2013.…”

Section: Methodsmentioning

confidence: 99%

“…Analyses of plasma cytokines, immunoglobulin (Ig)A/IgG response to periodontal pathogens, and clinical parameters of this population have been described previously 18 , 20 . Systemic IgA/IgG response to A. actinomycetemcomitans and Porphyromonas gingivalis was analyzed in multiserotype enzyme‐linked immunosorbent assay (ELISA), as described previously 20 .…”

Section: Methodsmentioning

confidence: 99%

“…It is not known whether presence of this bacterium is of importance for the pattern of clinical manifestation of the disease or whether its presence interferes with response to treatment of colonized individuals. A case‐control population of patients with CP was recently analyzed with regard to clinical manifestation, levels of systemic biomarkers linked to proinflammatory host response, and effect of treatment 18 . The aim of the present study is to examine the importance of presence of systemic A. actinomycetemcomitans Ltx reactivity for clinical manifestation of periodontitis, systemic biomarkers, and treatment susceptibility in previously examined patients and control individuals 18 …”

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confidence: 99%

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Systemic Aggregatibacter actinomycetemcomitans Leukotoxin‐Neutralizing Antibodies in Periodontitis

Johansson

Buhlin

Sorsa

et al. 2017

Journal of Periodontology

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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confidence: 99%

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Systemic Aggregatibacter actinomycetemcomitans Leukotoxin‐Neutralizing Antibodies in Periodontitis

Johansson

Buhlin

Sorsa

et al. 2017

Journal of Periodontology

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“…Serum antibody titers to HSP90, HSP70, and P. gingivalis LPS were suggested to be useful in predicting the response to periodontal therapy . Some studies have found a difference in the levels of serum HSP antibody between patients with and without periodontitis, whereas other studies have failed to find a difference . When the risk factors of periodontitis were considered, serum HSP65‐IgA and IgG 1 associated significantly with periodontitis, whereas HSP60‐IgG 2 associated with periodontal health .…”

Section: Molecular Mimicrymentioning

confidence: 99%

Mediators between oral dysbiosis and cardiovascular diseases

Pietiäinen

Liljestrand

Kopra

et al. 2018

European J Oral Sciences

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Clinical periodontitis is associated with an increased risk for cardiovascular diseases (CVDs) through systemic inflammation as the etiopathogenic link. Whether the oral microbiota, especially its quality, quantity, serology, and virulence factors, plays a role in atherogenesis is not clarified. Patients with periodontitis are exposed to bacteria and their products, which have access to the circulation directly through inflamed oral tissues and indirectly (via saliva) through the gastrointestinal tract, resulting in systemic inflammatory and immunologic responses. Periodontitis is associated with persistent endotoxemia, which has been identified as a notable cardiometabolic risk factor. The serology of bacterial biomarkers for oral dysbiosis is associated with an increased risk for subclinical atherosclerosis, prevalent and future coronary artery disease, and incident and recurrent stroke. In addition to species-specific antibodies, the immunologic response includes persistent, cross-reactive, proatherogenic antibodies against host-derived antigens. Periodontitis may affect lipoprotein metabolism at all levels, and all lipoprotein classes are affected. Periodontitis or its bacterial signatures may be involved not only in increased storage of proatherogenic lipids but also in attenuation of the anti-atherogenic processes, thereby putatively increasing the net risk of atherosclerosis. In this review we summarize possible molecular mediators between the dysbiotic oral microbiota and atherosclerotic processes.

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“…As such, oral health does not only have an impact on the oral cavity, but can be involved in the etiology of various diseases such as cardiovascular diseases e.g. endocarditis and stroke and systemic inflammatory diseases such as rheumatoid arthritis [46, 47]. …”

Section: Prevalent Biofilm Infectionsmentioning

confidence: 99%

Biofilm formation – what we can learn from recent developments

et al. 2018

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Although biofilms have been observed early in the history of microbial research, their impact has only recently been fully recognized. Biofilm infections, which contribute to up to 80% of human microbial infections, are associated with common human disorders, such as diabetes mellitus and poor dental hygiene, but also with medical implants. The associated chronic infections such as wound infections, dental caries and periodontitis significantly enhance morbidity, affect quality of life and can aid development of follow-up diseases such as cancer. Biofilm infections remain challenging to treat and antibiotic monotherapy is often insufficient, although some rediscovered traditional compounds have shown surprising efficiency. Innovative anti-biofilm strategies include application of anti-biofilm small molecules, intrinsic or external stimulation of production of reactive molecules, utilization of materials with antimicrobial properties and dispersion of biofilms by digestion of the extracellular matrix, also in combination with physical biofilm breakdown. Although basic principles of biofilm formation have been deciphered, the molecular understanding of the formation and structural organization of various types of biofilms has just begun to emerge. Basic studies of biofilm physiology have also resulted in an unexpected discovery of cyclic dinucleotide second messengers that are involved in interkingdom crosstalk via specific mammalian receptors. These findings even open up new venues for exploring novel anti-biofilm strategies.

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Association of periodontitis with persistent, pro‐atherogenic antibody responses

Abstract: Periodontitis is associated with persistently high levels of circulating antibodies that are reactive with pathogen- and host-derived antigens.

Cited by 25 publications

References 46 publications

Systemic Aggregatibacter actinomycetemcomitans Leukotoxin‐Neutralizing Antibodies in Periodontitis

Systemic Aggregatibacter actinomycetemcomitans Leukotoxin‐Neutralizing Antibodies in Periodontitis

Mediators between oral dysbiosis and cardiovascular diseases

Biofilm formation – what we can learn from recent developments

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