Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

Emokpae, Mathias Abiodun; Uadia, Patrick

doi:10.1155/2012/767501

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…e increased production of ROS in SCD can modify the response to a variety of pathophysiological conditions including inflammation, hypoxia, metabolism of drugs or alcohol, and deficiency in antioxidant enzymes. Reactive oxygen species can cause significant damage to biomolecules since membrane lipids readily react with ROS resulting in lipid peroxidation [24]. Our results demonstrated negative significant correlation between TG, LDL-C, HDL-C, and FRAP or GsH confirming that the accumulation of lipid will lead to the reduction of antioxidant defenses.…”

Section: Discussionsupporting

confidence: 55%

Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon

Kubong

Biapa

Bernard

et al. 2020

Advances in Hematology

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Dyslipidemia is highly prevalent in sickle cell anemia (SCA) patients and is one of the major risk factors for cardiovascular diseases induced by oxidative stress in Africa. The aim of this research was to investigate the correlation between higher atherogenic index of plasma (API) and oxidative stress in a group of patients living with SCA in Cameroon. Methods. A group of 85 homozygote SS patients (male and female) were enrolled at the Central hospital of Yaounde in Cameroon between May and October 2017. After informed consent through the signature of a consent form was obtained, the plasma was collected to determine the lipid profile while the lysate solution of RBC was used to explore some markers of oxidative stress using spectrophotometric methods. Results. Among the 85 patients included in our study, the mean age was 30 ± 5 years and the female to male ratio was 0.97. The majority of the patients (52–81%) had dyslipidaemia, and 22.4% of the patients demonstrated a higher level of atherogenic index of plasma. The patients with a higher level of total cholesterol (TC) (>240 mg/dl) and low-density lipoprotein (LDL-C) (>159 mg/dl) had at least 1,334 fold of malondialdeheyde (MDA) concentration than those with normal level. Also in the same patients, the higher atherogenic plasmatic index (API) significantly (p<0.05) increased with the concentration of MDA. Except HDL-C, the other parameters of lipid profile had significant (p<0.05) correlation with reduced glutathione (GsH) and total antioxidant capacity (TAC). The significant (p<0.05) and linear regression was found between the increased MDA and higher API. Conclusion. Dyslipidemia increases oxidative stress and higher API which leads to coronary vascular disease in patients with SCA.

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Section: Discussionsupporting

confidence: 55%

Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon

Kubong

Biapa

Bernard

et al. 2020

Advances in Hematology

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“…This observation is similar to previous reports from Nigeria [8], Egypt [9] and Qatar [5]. The decrease in antioxidant enzyme levels and activity could be explained by their susceptibility to ROS-induced oxidation [13, 14].…”

Section: Discussionsupporting

confidence: 91%

“…This finding may suggest that the overabundance of oxidative stress leads to consumption or inactivation this protective cofactor [13, 14]. Oxidative damage may alter both the structure and the function of the glomerulus due to its effects on mesangial and endothelial cells [8, 15]. Oxidative stress has been reported to oxidize angiotensinogen and convert it to angiotensin II (ATII) and to increase secondary angiotensin type 1 receptor (AT1R)-mediated generation of transforming growth factor-beta (TGFβ) in the kidney in SCA; excessive AT1R signaling causes SCA glomerulopathy [15, 16].…”

Section: Discussionmentioning

confidence: 99%

Albuminuria, serum antioxidant enzyme levels and markers of hemolysis and inflammation in steady state children with sickle cell anemia

et al. 2016

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BackgroundOxidative stress is thought to be involved in the pathogenesis of microalbuminuria in Sickle cell anemia (SCA). Antioxidant enzymes such as glutathione peroxidase (GPx) and Cu-Zn superoxide dismutase (SOD) may play an important protective role. This study aimed to evaluate the association between albuminuria and these two antioxidant enzymes.MethodsWe consecutively recruited Steady state children aged between 2 and 18 years old with established diagnosis of homozygous SCA in two hospitals of Kinshasa/DR Congo. The relationship between Urinary Albumin Creatinine Ratio (UACR) and other variables of interest (age, systolic blood pressure, diastolic blood pressure, plasma GPx and Cu-Zn SOD, free plasmatic hemoglobin, LDH, indirect bilirubin, white blood cells (WBC), percentage of fetal hemoglobin, serum iron, ferritin, CRP) was analyzed by Bivariate correlation (Pearson’s correlation coefficient). Microalbuminuria was defined by urine albumin/creatinine ratio between 30 and 299 mg/g.ResultsSeventy Steady state Black African children with SCA (56% boys; average age 9.9 ± 4.3 years; 53% receiving hydroxyurea) were selected. Prevalence of microalbuminuria was 11.8%. LDH (r = 0.260; p = 0.033) and WBC count (r = 0.264; p = 0.033) were positively correlated with UACR whereas GPx (− 0.328; p = 0.007) and Cu-Zn SOD (− 0.210; p = 0.091) were negatively correlated with UACR.ConclusionsAlbuminuria is associated with decreased antioxidant capacity and increased levels of markers of hemolysis and inflammation. Therefore, strategies targeting the reduction of sickling and subsequent hemolysis, oxidative stress and inflammation could help preventing or at least delaying the progression of kidney disease in SCA children.

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“…(16 ) and Emokpae et al (17) who found a significant association between AI and MA. This may have been caused by the fact that the study subjects came from different populations.…”

Section: Discussionmentioning

confidence: 92%

“…This may have been caused by the fact that the study subjects came from different populations. Our study was conducted on healthy subjects, whereas the study by Amirkhizi et al, (15) Linna M et al (16) and Emokpae et al (17) were carried out on pre-hypertensive women, subjects with hyperlipidemia, and subjects with adult sickle cell nephropathy.…”

Section: Discussionmentioning

confidence: 99%

Higher triglyceride serum level increases atherosclerotic index in subjects 50-70 years of age

Mawi

Chondro

Chudri

2016

UnivMed

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BACKGROUNDAtherosclerosis, the underlying cause of heart attack, stroke and peripheral disease, is a main cause of morbidity and mortality worldwide. Hypercholesterolemia and hypertriglyceridemia are independent factors in the development and progression of atherosclerosis. The atherosclerotic index (AI) is a strong indicator of cardiovascular heart disease. The objective of this study was to determine the relationship between lipid serum level and AI in subjects 50-70 years of age.

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Association of Oxidative Stress Markers with Atherogenic Index of Plasma in Adult Sickle Cell Nephropathy

Cited by 13 publications

References 26 publications

Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon

Relationship between Higher Atherogenic Index of Plasma and Oxidative Stress of a Group of Patients Living with Sickle Cell Anemia in Cameroon

Albuminuria, serum antioxidant enzyme levels and markers of hemolysis and inflammation in steady state children with sickle cell anemia

Higher triglyceride serum level increases atherosclerotic index in subjects 50-70 years of age

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