Association of oxidative stress and dynamic thiol-disulphide homeostasis with atopic dermatitis severity and chronicity in children: a prospective study

Uysal, Pınar; Avcıl, Sibelnur; Neşeli̇oğlu, Salim; Bıçer, Cemile; Çatal, Ferhat

doi:10.1111/ced.13219

Cited by 20 publications

(25 citation statements)

References 26 publications

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“…In detail, four studies were published in the 1990s, nine in the 2000s, and 21 in the last decade. Different geographical areas (and ethnicities) were not uniformly represented: 16 studies [17,18,23,24,27,[32][33][34][35][36][37][38]40,42,45,46] were performed in Eastern Asia (8 in Japan, 6 in Korea, 2 in Taiwan), nine [21,28,31,39,41,43,44,47,48] in Europe (3 in Russia, 2 in Germany, 1 in Finland, Italy, Norway, Switzerland), four [20,22,29,30] in Middle Eastern countries (3 in Turkey, 1 in Israel), two [25,26] in Southern Asia (Bangladesh, India), and one [49] in the United States of America. Another study [19] included patients from multiple Canadian and European centers.…”

Section: Resultsmentioning

confidence: 99%

“…In the serum of AD patients, significantly elevated levels of clusterin (correlated with disease severity) [24], significantly decreased levels of beta carotene [34], catalase [26], gamma tocopherol [39], glutathione peroxidase [26], Mg [30], NO [22], retinol [34], and levels of Cu similar to those of healthy controls [30] were found. Decreased also were, in AD patients, the serum total antioxidant capacity [38], serum disulphide, disulphide/native thiol ratio and disulphide/total thiol ratio [20], NO/melatonin ratio [22], nitrite/nitrate (NO x -) [45].…”

Section: Biomarkersmentioning

confidence: 99%

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Oxidative Stress and Atopic Dermatitis

et al. 2020

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Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have a significant role in atopic dermatitis, but our understanding is still incomplete, at least concerning in vivo data, because of limitations of available literature. Research consists of 33 papers published in 28 years, was not always performed on large study populations, represents a limited number of countries and ethnicities—not always in proportion to their size—and is scattered over multiple papers that, in the majority of cases, cannot be pooled and/or compared because many biomarkers were studied, in different tissues and with different methods. Further, larger studies appear warranted and necessary to shed more light on this aspect of atopic dermatitis, which is important not only to improve our understanding of this disease, but also for potential clinical and therapeutic implications.

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Section: Resultsmentioning

confidence: 99%

Section: Biomarkersmentioning

confidence: 99%

Oxidative Stress and Atopic Dermatitis

et al. 2020

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“…Moreover, disulfide to NT ratio was positively correlated and NT to TT ratio was negatively correlated with higher scores assessing atopic dermatitis severity. Authors have proposed that decreased disulfide level might result from rebound phenomenon to continue protective influence by facilitating the neutralization of oxidative state [74].…”

Section: Dermatologic Disordersmentioning

confidence: 99%

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Erel

Erdoğan

2020

Turk J Med Sci

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Dynamic thiol-disulfide homeostasis (TDH) is a new area has begun to attract more scrutiny. Dynamic TDH is reversal of thiol oxidation in proteins and represents the status of thiols (-SH) and disulfides (-S-S-). Organic compounds containing the sulfhydryl group is called thiol, composed of sulfur and hydrogen atoms. Disulfides are the most important class of dynamic, redox responsive covalent bonds build in between two thiol groups. For many years, thiol levels were analyzed by several methods. During last years, measurements of disulfide levels have been analyzed by a novel automated method, developed by Erel and Neselioglu. In this method, addition to thiol-termed as native thiol-levels, disulfide levels were also measured and sum of native thiol and disulfide levels were termed as total thiol. Therefore, TDH was begun to be understood in organism. In healthy humans, TDH is maintained within a certain range. Dysregulated dynamic TDH has been implicated several disorders with unknown etiology. A growing body of evidence has demonstrated that the thiol-disulfide homeostasis is involved in variety diseases, such as diabetes mellitus, hypertension, non-small cell lung cancer, Familial Mediterranean fever, inflammatory bowel diseases, occupational diseases, gestational diabetes mellitus and preeclampsia. These results may elucidate some pathogenic mechanism or may be a predictor indicating diagnostic clue, prognostic marker or therapeutic sign. In conclusion, protection of the thiol disulfide homeostasis is of great importance for the human being. Evidence achieved so far has proposed that thiol-disulfide homeostasis is an important issue needs to elucidate wholly.

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“…It also indicated that there was a decrease in the natural and total thiol levels in both acute urticaria and chronic spontaneous urticaria groups, thus suggesting that the activation of urticaria had an impact on the thiol/disulphide levels [9]. In a study carried out by Uysal et al, it has been reported that both oxidative stress and impaired thiol-disulphide balance are associated with childhood atopic dermatitis [18]. Although oxidative stress has been shown to be one of the factors responsible for the pathogenesis of psoriasis in various studies, its role is still unclear.…”

Section: Discussionmentioning

confidence: 94%

“…The thiol-disulphide balance has been researched in a limited number of dermatoses (urticaria, basal cell carcinoma, atopic dermatitis) until now [9,10,18]. Demirsen et al carried out research on 34 patients with basal cell carcinoma and a group of 30 healthy individuals to determine the thiol-disulphide balance.…”

Section: Discussionmentioning

confidence: 99%

Thiol/disulphide balance in patients with psoriasis

Aksoy

Kirmit

2020

pdia

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A b s t r a c tIntroduction: Psoriasis is a common chronic inflammatory skin disease with unknown etiopathogenesis. Aim: To examine the thiol/disulfide balance in psoriasis patients and to compare the results with a healthy control group. Material and methods: Eighty patients with psoriasis and 80 healthy individuals who were age-and gender-matched with these patients were included in this study. Serum native thiol, disulfide and total thiol levels were measured by a new automated method developed by Erel and Neselioglu. Disulphide/total thiol, disulphide/ native thiol and native thiol/total thiol were calculated. Results: While there was no statistically significant difference in terms of disulphide levels (SS) between the patient and control groups (p > 0.05), there were significant differences in terms of total thiol and native thiol (SH) levels, SS/SH, SS/total thiol and SH/total thiol ratios between the patient and control groups (p < 0.05). There was a statistically significant relationship between duration of the disease and the disulfide/native thiol ratio (p > 0.05). Conclusions: In recent years, there have been few studies on the role of oxidative stress in the etiopathogenesis of psoriasis. In this study, we investigated in psoriasis patients, thiol/disulfide balance as a new oxidative stress marker. The results were compared with a healthy control group. Our results showed that thiol/disulphide balance shifted towards disulphide in psoriasis patients. This is important as a finding that supports the role of oxidative stress in the pathogenesis of psoriasis.

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Association of oxidative stress and dynamic thiol-disulphide homeostasis with atopic dermatitis severity and chronicity in children: a prospective study

Abstract: Both OS and impaired dTDH were found to be related to childhood AD. None of the OS parameters was associated with AD severity. dTDH is a possible diagnostic tool to predict AD chronicity.

Cited by 20 publications

References 26 publications

Oxidative Stress and Atopic Dermatitis

Oxidative Stress and Atopic Dermatitis

Thiol-disulfide homeostasis: an integrated approach with biochemical and clinical aspects

Thiol/disulphide balance in patients with psoriasis

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