Association of NOD1 and NOD2 genes polymorphisms with<i>Helicobacter pylori</i>related gastric cancer in a Chinese population

Wang, Peng; Zhang, Li; Jiang, Jianming; Ma, Dan; Tao, Haoxia; Yuan, Shengling; Wang, Yanchun; Wang, Ling-Chun; Liang, Hao; Zhang, Zhao-Shan; Liu, Chun‐Jen

doi:10.3748/wjg.v18.i17.2112

Cited by 39 publications

(42 citation statements)

References 35 publications

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“…For example, rs2066842 (P268S) has been reported to be a risk variant for GC in Polish and German populations, but we could not analyze this SNP due to poor cluster separation of its genotypes . Moreover, rs3135500 has been reported to increase the risk for GC in the Chinese population, a finding not confirmed by us . Nevertheless, according to the haploview analysis of CEU HapMap population, the haplotype inversely associated with GC in our study carries the wild‐type or major variants of these two polymorphisms.…”

Section: Discussioncontrasting

confidence: 66%

“…10,11 Moreover, rs3135500 has been reported to increase the risk for GC in the Chinese population, a finding not confirmed by us. 32 Nevertheless, according to the haploview analysis of CEU HapMap population, the haplotype inversely associated with GC in our study carries the wild-type or major variants of these two polymorphisms. In an Italian population, rs2066844 and rs5743293 were also reported to increase susceptibility to GC, but these SNPs are not included in the HapMap version we used.…”

Section: Discussionmentioning

confidence: 49%

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Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer‐eurgast cohort

Companioni

Bonet

Muñoz

et al. 2013

Intl Journal of Cancer

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Helicobacter pylori is a recognized causal factor of noncardia gastric cancer (GC). Lipopolysaccharide and peptidoglycan of this bacterium are recognized by CD14, TLR4 and NOD2 human proteins, while NFKB1 activates the transcription of pro‐inflammatory cytokines to elicit an immune response. Single nucleotide polymorphisms (SNPs) in these genes have been associated with GC in different populations. We genotyped 30 SNPs of these genes, in 365 gastric adenocarcinomas and 1,284 matched controls from the European Prospective Investigation into Cancer cohort. The association with GC and its histological and anatomical subtypes was analyzed by logistic regression and corrected for multiple comparisons. Using a log‐additive model, we found a significant association between SNPs in CD14, NOD2 and TLR4 with GC risk. However, after applying the multiple comparisons tests only the NOD2 region remained significant (p = 0.009). Analysis according to anatomical subtypes revealed NOD2 and NFKB1 SNPs associated with noncardia GC and CD14 SNPs associated with cardia GC, while analysis according to histological subtypes showed that CD14 was associated with intestinal but not diffuse GC. The multiple comparisons tests confirmed the association of NOD2 with noncardia GC (p = 0.0003) and CD14 with cardia GC (p = 0.01). Haplotype analysis was in agreement with single SNP results for NOD2 and CD14 genes. From these results, we conclude that genetic variation in NOD2 associates with noncardia GC while variation in CD14 is associated with cardia GC.

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Section: Discussioncontrasting

confidence: 66%

Section: Discussionmentioning

confidence: 49%

Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer‐eurgast cohort

Companioni

Bonet

Muñoz

et al. 2013

Intl Journal of Cancer

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“…There are several studies which demonstrated that the polymorphisms of the NOD1 (nucleotide-binding oligomerization domain) and NOD2 genes in different populations were related to variant clinical outcomes of H pylori infection. Moreover, it was shown that NOD1 and NOD2 genes polymorphisms and/or mutation induced the incidence of gastric carcinoma in different populations, in recently reports (Wang et al, 2012;Zhang et al, 2012). The risk for the development of gastric cancer in patients with a family history of gastric cancer has been reported to be as high as 1.6-2.6 folds (Kondo et al, 2003;Kawasaki et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Clinical Factors Related with Helicobacter Pylori Infection - Is there an Association with Gastric Cancer History in First-Degree Family Members?

Demirel¹,

Akkaş²,

Vural³

2013

Asian Pacific Journal of Cancer Prevention

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“…Nucleotide-binding oligomerization domain 1 (NOD1) receptor, is a relatively recently described cytosolic PRR known to execute important functions in the immune system (Girardin et al, 2001, Ogura et al, 2001) by recognizing a wide range of microbes bearing the specific meso-diaminopimelic acid (meso-DAP) moiety and mediating the corresponding inflammatory response to these infectious agents (Carneiro et al, 2004). Not only is NOD1 important in host defense and autoimmune diseases, but recently, it has also been implicated in tumorigenesis for a number of cancers, including gastric cancer (Wang et al, 2012), head and neck carcinomas (Millrud et al, 2013), oral squamous cell cancer (Wang et al, 2014), prostate adenocarcinoma (Kang et al, 2012), and lung cancer (Ozbayer et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis

et al. 2020

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While emerging data suggest nucleotide oligomerization domain receptor 1 (NOD1), a cytoplasmic pattern recognition receptor, may play an important and complementary role in the immune response to bacterial infection, its role in cancer metastasis is entirely unknown. Hence, we sought to determine the effects of NOD1 on metastasis. NOD1 expression in paired human primary colon cancer, human and murine colon cancer cells were determined using immunohistochemistry and immunoblotting (WB). Clinical significance of NOD1 was assessed using TCGA survival data. A series of in vitro and in vivo functional assays, including adhesion, migration, and metastasis, was conducted to assess the effect of NOD1. C12-iE-DAP, a highly selective NOD1 ligand derived from gram-negative bacteria, was used to activate NOD1. ML130, a specific NOD1 inhibitor, was used to block C12-iE-DAP stimulation. Stable knockdown (KD) of NOD1 in human colon cancer cells (HT29) was constructed with shRNA lentiviral transduction and the functional assays were thus repeated. Lastly, the predominant signaling pathway of NOD1-activation was identified using WB and functional assays in the presence of specific kinase inhibitors. Our data demonstrate that NOD1 is highly expressed in human colorectal cancer (CRC) and human and murine CRC cell lines. Clinically, we demonstrate that this increased NOD1 expression negatively impacts survival in patients with CRC. Subsequently, we identify NOD1 activation by C12-iE-DAP augments CRC cell adhesion, migration and metastasis. These effects are predominantly mediated via the p38 mitogen activated protein kinase (MAPK) pathway. This is the first study implicating NOD1 in cancer metastasis, and thus identifying this receptor as a putative therapeutic target.

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Association of NOD1 and NOD2 genes polymorphisms withHelicobacter pylorirelated gastric cancer in a Chinese population

Abstract: Genetic polymorphisms in NOD1 and NOD2 may interact with H. pylori infection and may play important roles in promoting the development of gastric cancer in the Chinese population.

Cited by 39 publications

References 35 publications

Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer‐eurgast cohort

Polymorphisms of Helicobacter pylori signaling pathway genes and gastric cancer risk in the European prospective investigation into cancer‐eurgast cohort

Clinical Factors Related with Helicobacter Pylori Infection - Is there an Association with Gastric Cancer History in First-Degree Family Members?

Activation of the pattern recognition receptor NOD1 augments colon cancer metastasis

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