Association of neutrophil-to-lymphocyte ratio and microalbuminuria in patients with normal eGFR

Kutlugun, Aysun Aybal; Ebinç, Fatma Ayerden; Öztürk, Müjgan Tek; Efe, Fatma Kaplan; Karadağ, İbrahim; Eser, Murat; Ünsal, Oktay; Karakaya, Serdar

doi:10.1515/rjim-2017-0036

Cited by 8 publications

(2 citation statements)

References 20 publications

(36 reference statements)

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“…Our results were in line with study of Kutlugun et al (25) who stated that there was a positive correlation between the urine albumin level and NLR in the whole study groups (r = 0.214, p < 0.005). In non-diabetic patients there was a significant positive correlation between NLR and albuminuria (r = 0.324, p = 0.013).…”

Section: Discussionsupporting

confidence: 93%

Neutrophil-to-Lymphocyte Ratio as a Novel Marker for Early Detection of Hypertensive Nephropathy and as a Predictor of Worsening Renal Functions in Hypertensive Patients

Ibrahim¹,

Shahawy²,

Mohammed³

et al. 2022

The Egyptian Journal of Hospital Medicine

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Background: Hypertension (HTN) is one of the most important causes of chronic kidney disease (CKD) and may also be the presenting feature of asymptomatic primary renal disease. However, a progressive reduction in estimated glomerular filtration rate (eGFR) and increased albuminuria indicate progressive loss of renal function, an alteration of renal function is an insensitive marker of renal impairment because a major reduction in renal function is needed before serum creatinine rise. Low-grade inflammation plays crucial pathophysiological role in both hypertension and CKD. Objective: This work was aimed to study neutrophil-to-lymphocyte ratio (NLR) as a marker for early detection of hypertensive kidney disease and as a predictor of worsening renal function in patients with high normal blood pressure and in hypertensive patients. Patient and methods: This case control study included a total of 125 hypertensive patients and 50 subjects with normal blood pressure, attending at

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Section: Discussionsupporting

confidence: 93%

Neutrophil-to-Lymphocyte Ratio as a Novel Marker for Early Detection of Hypertensive Nephropathy and as a Predictor of Worsening Renal Functions in Hypertensive Patients

Ibrahim¹,

Shahawy²,

Mohammed³

et al. 2022

The Egyptian Journal of Hospital Medicine

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“…Because some inflammatory cytokines, such as hsCRP, interleukin-6 and TNF-α are limited to research for nonconventional tests, NLR would be more easily available for clinical practice [31]. NLR displays a prognostic value for proteinuria [32, 33], mortality and RRT [34]. Nevertheless, recent evidence indicates NLR was not an independent predictor of CKD progression in CKD stage 2–4 patients [35].…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Yuan

Wang²,

Peng

et al. 2019

J Transl Med

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BackgroundChronic kidney disease (CKD) leads to end-stage renal failure and cardiovascular events. An attribute to these progressions is abnormalities in inflammation, which can be evaluated using the neutrophil-to-lymphocyte ratio (NLR). We aimed to investigate the association of NLR with the progression of end stage of renal disease (ESRD), cardiovascular disease (CVD) and all-cause mortality in Chinese patients with stages 1–4 CKD.MethodsPatients with stages 1–4 CKD (18–74 years of age) were recruited at 39 centers in 28 cities across 22 provinces in China since 2011. A total of 938 patients with complete NLR and other relevant clinical variables were included in the current analysis. Cox regression analysis was used to estimate the association between NLR and the outcomes including ESRD, CVD events or all-cause mortality.ResultsBaseline NLR was related to age, hypertension, serum triglycerides, total serum cholesterol, CVD history, urine albumin to creatinine ratio (ACR), chronic kidney disease-mineral and bone disorder (CKD-MBD), hyperlipidemia rate, diabetes, and estimated glomerular filtration rate (eGFR). The study duration was 4.55 years (IQR 3.52–5.28). Cox regression analysis revealed an association of NLR and the risk of ESRD only in patients with stage 4 CKD. We did not observe any significant associations between abnormal NLR and the risk of either CVD or all-cause mortality in CKD patients in general and CKD patients grouped according to the disease stages in particular.ConclusionOur results suggest that NLR is associated with the risk of ESRD in Chinese patients with stage 4 CKD. NLR can be used in risk assessment for ESRD among patients with advanced CKD; this application is appealing considering NLR being a routine test.Trial registration ClinicalTrials.gov Identifier NCT03041987. Registered January 1, 2012. (retrospectively registered) (https://www.clinicaltrials.gov/ct2/show/NCT03041987?term=Chinese+Cohort+Study+of+Chronic+Kidney+Disease+%28C-STRIDE%29&rank=1)Electronic supplementary materialThe online version of this article (10.1186/s12967-019-1808-4) contains supplementary material, which is available to authorized users.

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Can immature granulocytes and neutrophil-lymphocyte ratio be biomarkers to evaluate diabetic nephropathy?: A cross-sectional study

Yay,

Bayram,

Aggul

et al. 2024

Journal of Diabetes and its Complications

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Association of neutrophil-to-lymphocyte ratio and microalbuminuria in patients with normal eGFR

Abstract: Higher NLR levels were found in microalbuminuric patients with normal eGFR. Also a significant positive correlation was observed between albuminuria and NLR.

Cited by 8 publications

References 20 publications

Neutrophil-to-Lymphocyte Ratio as a Novel Marker for Early Detection of Hypertensive Nephropathy and as a Predictor of Worsening Renal Functions in Hypertensive Patients

Neutrophil-to-Lymphocyte Ratio as a Novel Marker for Early Detection of Hypertensive Nephropathy and as a Predictor of Worsening Renal Functions in Hypertensive Patients

Neutrophil-to-lymphocyte ratio and incident end-stage renal disease in Chinese patients with chronic kidney disease: results from the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE)

Can immature granulocytes and neutrophil-lymphocyte ratio be biomarkers to evaluate diabetic nephropathy?: A cross-sectional study

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