Association of Neutrophil/Lymphocyte Ratio and Retinal Vein Occlusion

Dursun, Ayhan; Ozturk, Sultan; Yücel, Hasan; Özeç, Ayşe Vural; Dursun, Feyza; Toker, Mustafa; Erdoğan, Haydar; Arıcı, Mustafa Kemal; Topalkara, Ayşen

doi:10.5301/ejo.5000570

Cited by 59 publications

(44 citation statements)

References 38 publications

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“…Dursun et al compared 40 patients with retinal vein occlusion with a control group and found that the NLR levels of patients with retinal vein occlusion were significantly higher than those in control patients. [19] The sensitivity and specificity of NLR reported by Dursun et al were found to be 72% and 100%, respectively (cut-off value: 1.89), whereas in our study, these figures were 72% and 69%, respectively (cut-off value: 1.82). [19] PLR, which is calculated via dividing a patient's platelet count by the number of lymphocytes, is a cheap and easy test that reveals the condition of platelets and white blood cells.…”

Section: Discussioncontrasting

confidence: 85%

“…[19] The sensitivity and specificity of NLR reported by Dursun et al were found to be 72% and 100%, respectively (cut-off value: 1.89), whereas in our study, these figures were 72% and 69%, respectively (cut-off value: 1.82). [19] PLR, which is calculated via dividing a patient's platelet count by the number of lymphocytes, is a cheap and easy test that reveals the condition of platelets and white blood cells. Thrombocytes play a significant role in coronary artery disease and cardiovascular disorders.…”

Section: Discussioncontrasting

confidence: 85%

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Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Atum

Alagöz

2020

JOVR

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Purpose: This study aimed to compare the neutrophil-to-lymphocyte (NLR) and plateletto- lymphocyte (PLR) ratios in patients with retinal artery occlusion (RAO) with those from a healthy control population and to identify the relationship between them. Methods: Forty-six patients with RAO and fifty-one healthy control subjects were included in this retrospective case-control study. RAO was diagnosed following an ophthalmic examination and fluorescein angiography (FA). Blood neutrophil, lymphocyte, and platelet counts were recorded for each of the 97 subjects, from which NLR and PLR values were calculated. Results: There were 46 patients (28 male [M], 18 female [F]) in the RAO group and 51 patients (27 M, 24 F) in the control group. No significant differences were found between patients with RAO and the control subjects in terms of gender and age (P > 0.05). Patients with RAO had significantly increased NLR values (2.85 ± 1.70) than the control subjects (1.63 ± 0.59, P < 0.001). The mean PLR in patients with RAO was 123.69 ± 64.98, while that in control subjects was 103.08 ± 36.95; there was no significant difference between the two groups (P = 0.055). A logistic regression analysis revealed that NLRs were 3.8 times higher in patients with RAO than in control subjects (odds ratio = 3.880; 95% confidence interval = 1.94 to 7.74; P < 0.001). Conclusion: NLRs were significantly increased in patients with RAO compared to the control subjects.

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Section: Discussioncontrasting

confidence: 85%

Section: Discussioncontrasting

confidence: 85%

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Atum

Alagöz

2020

JOVR

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“…[11] Oküler hastalıklar sistemik inflamasyondan ziyade lokal bir inflamatuar yanıta neden olmasına rağmen NLO'nun yaşa bağlı makular dejenerasyon, retinal ven tıkanıklığı, non-arteritik anterior iskemik optik nöropati, vernal keratokonjonktivit, kuru göz ve primer açık açılı glokom gibi çeşitli göz hastalıklarında ilişkili olduğu saptanmış-tır. [25][26][27][28][29][30][31] NLO'nun lokal inflamatuar hastalıklarda anlamlı olabilmesi için sistemik kan parametrelerinde değişiklik yapması gerekir. TO'deki inflamasyon aslında sistemik inflamasyonun bir sonucudur ve kan parametrelerini değiştirebilir.…”

Section: Discussionunclassified

The Evaluation of Neutrophil to Lymphocyte ratio and mean platelet volume in patients with active and inactive thyroid orbitopathy

et al. 2018

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“…Ilhan et al (21) reported that an elevated NLR can be a potential indicator of vitreomacular traction syndrome, regardless of the etiology. Dursun et al (22) suggested that the optimal cut-off value of NLR to predict retinal vein occlusion with 72.5% sensitivity and 100% specificity was 1.89. These reports revealed the critical role of inflammatory cascades in the pathophysiology of these diseases and the diagnostic value of NLR.…”

Section: Discussionmentioning

confidence: 99%

The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio in Severe Grades of Diabetic Retinopathy Short Title: NLR in Diabetic Retinopathy

İlhan¹

2019

Beyoglu Eye J

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The aim of this study was to define the optimal cutoff value of the neutrophil/lymphocyte ratio (NLR) to predict severe grades of diabetic retinopathy (DR). Methods: A total of 40 patients with proliferative DR (PDR) and 40 patients with severe non-proliferative DR (NPDR) were included this prospective, case control study, and 35 age-and sex-matched healthy subjects were recruited as a control group. White blood cell (WBC) count mean values and ratios were compared between the groups. Results: The groups were statistically similar in terms of age and sex. The neutrophil, lymphocyte, monocyte, platelet counts, and main platelet volume (MPV) values were similar in all 3 groups (all p values >0.05). The mean NLR was 2.67±1.02 in the PDR cases, 2.16±0.58 in severe NPDR, and 1.85±0.49 in the control group, which represented a statistically significant difference between the 3 groups (p=0.003). In post-hoc analysis, the NLR of the PDR and severe NPDR groups was statistically significantly greater than that of the control group (p=0.002 and p=0.048, respectively), but there was no statistically significant difference between the PDR and severe NPDR groups (p=0.083). The monocyte/lymphocyte, platelet/lymphocyte, and MPV/lymphocyte ratios were also similar in all 3 groups (all p values >0.05). Conclusion: An NLR value of 2.11 or more predicted DR (PDR or severe NPDR) with a sensitivity of 76% and a specificity of 80%.

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Association of Neutrophil/Lymphocyte Ratio and Retinal Vein Occlusion

Abstract: The current study demonstrated that higher NLR was associated with the development of RVO. The NLR may be used as a predictive tool for identifying risk for RVO.

Cited by 59 publications

References 38 publications

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

The Evaluation of Neutrophil to Lymphocyte ratio and mean platelet volume in patients with active and inactive thyroid orbitopathy

The Optimal Cutoff Value of Neutrophil/Lymphocyte Ratio in Severe Grades of Diabetic Retinopathy Short Title: NLR in Diabetic Retinopathy

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