Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios in Patients with RetinalArtery Occlusion

Abstract

Purpose: This study aimed to compare the neutrophil-to-lymphocyte (NLR) and plateletto- lymphocyte (PLR) ratios in patients with retinal artery occlusion (RAO) with those from a healthy control population and to identify the relationship between them.
 Methods: Forty-six patients with RAO and fifty-one healthy control subjects were included in this retrospective case-control study. RAO was diagnosed following an ophthalmic examination and fluorescein angiography (FA). Blood neutrophil, lymphocyte, and platelet counts were recorded for each of the 97 subjects, from which NLR and PLR values were calculated.
 Results: There were 46 patients (28 male [M], 18 female [F]) in the RAO group and 51 patients (27 M, 24 F) in the control group. No significant differences were found between patients with RAO and the control subjects in terms of gender and age (P > 0.05). Patients with RAO had significantly increased NLR values (2.85 ± 1.70) than the control subjects (1.63 ± 0.59, P < 0.001). The mean PLR in patients with RAO was 123.69 ± 64.98, while that in control subjects was 103.08 ± 36.95; there was no significant difference between the two groups (P = 0.055). A logistic regression analysis revealed that NLRs were 3.8 times higher in patients with RAO than in control subjects (odds ratio = 3.880; 95% confidence interval = 1.94 to 7.74; P < 0.001).
 Conclusion: NLRs were significantly increased in patients with RAO compared to the control subjects.

Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) are more prominent in retinal artery occlusion (RAO) compared to retinal vein occlusion (RVO)

“…According to Sonmez et al [ 13 ], lymphocyte counts can be used as a measure for general bad health and physiological stress. In the present study, we discovered that lymphocyte levels in the RAO and RVO groups were significantly lower than those in the control group, which was consistent with earlier research [ 19 , 22 , 24 , 26 , 43 ]. In this study, lymphocyte levels in the RAO group were likewise considerably lower than those in the RVO group.…”

“…Recent research suggests that increased neutrophil counts contribute to tumor growth and metastasis by releasing chemokines (CK) like IL-8, angiopoietin-1, matrix metalloproteinase-9, and vascular endothelial growth factor (VEGF), which are responsible for the formation of macular edema in some retinal vascular diseases [ 32 , 33 ]. In this study, we discovered that neutrophil levels in the RAO group were considerably greater than those in the control group, which is consistent with previous studies [ 24 – 26 ]. Additionally, we discovered that neutrophil levels were significantly higher in the RVO group than in the control group in this study.…”

“…Prior researches have looked at the effects of NLR and PLR on predicting RAO or RVO [ 19 – 26 , 43 , 49 , 50 ]. In some investigations, NLR has already been shown to be a unique marker for predicting RAO [ 24 , 26 ]. Furthermore, PLR was also predictive of RAO in this investigation, which contradicts prior findings.…”

“…Some studies suggest that arterial thrombosis contains more NETs than venous thrombosis [ 39 ]. Although previous studies have shown NLR and/or PLR might be the potential biomarkers in RAO or RVO [ 19 – 26 ], we would like to explore if there is some difference between them. Finally, we found that in RAO, NLR and PLR were more significant than in RVO.…”

“…The connection between NLR and RVO was revealed ( Table 1 ) [ 19 – 23 ]. Furthermore, the monocyte to high-density lipoprotein ratio (MHR), rather than PLR, may be a useful predictor for the development of RAO [ 24 – 26 ].…”