Association of Mouse Pathogenic Strain of Echo Virus Type 9 with Aseptic Meningitis.

Abstract

depression of heat production. The drop in body temperature of the restrained rat, in fact, appears to be the cause of the drop in oxygen consumption (metabolism), for if the reverse were true the 1l3l uptake (thyroid metabolism) should have been higher in the nonrestrained than in the restrained animals.Summary. Thyroid 11'3f uptake by restrained rats was higher at one hour, and lower at 4 hours, than that of nonrestrained control animals. The lower the body temperature of the restrained animals at 4 hours, the lower the IZz3l uptake by the thyroid. Restrained hypothermic rats had a significantly greater thyroid uptake of than equally hypothermic nonrestrained animals. It is concluded that hypothermia of restrained animals can not be ascribed to depressed basal metabolism.

Portraits of Viruses: the Picornaviruses

“…The mouse-patho genic prototype for coxsackievirus A23 turned out to be a host-range variant of a virus already established as echovirus type 9. The confusion in classification can be seen in the title of a paper published in 1957,'Association of mouse pathogenic strains of echovirus type 9 with aseptic meningitis ' [McLean and Melnick, 1957], when the cardinal property of an echovirus was its failure to produce disease in mice! In efforts to deal with these problems, the USA Committee on Enteroviruses in 1962 had suggested that all previously recognized polio-, coxsackie-, and echoviruses be designated simply as enteroviruses and that each be given a serial number.…”

Viruses of Human Diseases

“…The first British isolations of this virus from the throat and faeces of patients with aseptic meningitis were made in 1955 by McLean and Melnick (1957) in East Anglia. Some strains had, however, also been found in 1954 in London, and these came from children with a maculopapular rash and increased cells and protein in the C.S.F.…”

Aseptic meningitis due to infection with ECHO virus (Type 9)

“…Lyophilized Bourn virus was sent to Dr J. L. Melnick of Yale University, Section of Preventive Medicine. He has reported t h a t ' Bourn' virus belongs to the ECHO group of viruses, Type 9 (McLean & Melnick, 1957).…”