Association of MIR-499a expression and seed region variant (rs3746444) with cardiovascular disease in Egyptian patients

Abstract

Circulating miR-499a levels could be a useful biomarker, discriminating acute MI within 12 hours from healthy subjects. Its variant rs3746444 A/G is associated with increased susceptibility to acute MI and CAD in Egyptian population.

Potential Impact of MicroRNA Gene Polymorphisms in the Pathogenesis of Diabetes and Atherosclerotic Cardiovascular Disease

“…The rs3746444 (GG genotype) which is present in 20 intron of cardiac β-myosin heavy chain 7B gene of human has been associated with myocardial infarction in Chinese and Egyptian populations [105][106][107]. MiR-499 ( Figure 2B) is present in skeletal muscles, the myocardium and brain [105,108].…”

Value of Blood-Based microRNAs in the Diagnosis of Acute Myocardial Infarction: A Systematic Review and Meta-Analysis

“…Of these articles, 21 were excluded for the following reasons: review article ( n = 4), not about AMI ( n = 14), and not a diagnostic study ( n = 3). Finally, 58 studies investigating plasma, serum, or peripheral venous blood miRNAs in the diagnosis of AMI were identified as eligible for inclusion in this systematic review (Adachi et al, 2010 ; Ai et al, 2010 ; Cheng et al, 2010 ; Corsten et al, 2010 ; D'Alessandra et al, 2010 ; Wang et al, 2010 , 2011 , 2013 , 2014 , 2016 , 2019 ; Gidlöf et al, 2011 , 2013 ; Meder et al, 2011 ; Zile et al, 2011 ; Devaux et al, 2012 , 2015 ; Long et al, 2012a , b ; Li C. et al, 2013 ; Li Y. Q. et al, 2013 ; Lu et al, 2013 ; Olivieri et al, 2013 ; He et al, 2014 ; Hsu et al, 2014 ; Huang et al, 2014 ; Li L. M. et al, 2014 ; Li Z. et al, 2014 ; Peng et al, 2014 ; Xiao et al, 2014 ; Białek et al, 2015 ; Chen et al, 2015 ; Gao et al, 2015 ; Han et al, 2015 ; Ji et al, 2015 ; Li et al, 2015 ; Liu et al, 2015 , 2018 ; Yao et al, 2015 ; Zhang L. et al, 2015 ; Zhang R. et al, 2015 ; Zhao et al, 2015 ; Ke-Gang et al, 2016 ; Shalaby et al, 2016 ; Yang et al, 2016 , 2017 ; Zhang et al, 2016 , 2018 ; Zhu et al, 2016 ; Guo et al, 2017 ; Agiannitopoulos et al, 2018 ; Fawzy et al, 2018 ; Yi and An, 2018 ; Bukauskas et al, 2019 ; Li H. et al,…”

“…Seven studies performed miRNA screening to compare blood-based miRNAs between AMI patients and control groups (Adachi et al, 2010 ; D'Alessandra et al, 2010 ; Meder et al, 2011 ; Li C. et al, 2013 ; Hsu et al, 2014 ; Huang et al, 2014 ; Li et al, 2015 ). Fifty-one articles identified miRNAs based on their own previous studies or based on the literature (Ai et al, 2010 ; Cheng et al, 2010 ; Corsten et al, 2010 ; Wang et al, 2010 , 2011 , 2013 , 2014 , 2016 , 2019 ; Gidlöf et al, 2011 , 2013 ; Zile et al, 2011 ; Devaux et al, 2012 , 2015 ; Long et al, 2012a , b ; Li Y. Q. et al, 2013 ; Lu et al, 2013 ; Olivieri et al, 2013 ; He et al, 2014 ; Li L. M. et al, 2014 ; Li Z. et al, 2014 ; Peng et al, 2014 ; Xiao et al, 2014 ; Białek et al, 2015 ; Chen et al, 2015 ; Gao et al, 2015 ; Han et al, 2015 ; Ji et al, 2015 ; Liu et al, 2015 , 2018 ; Yao et al, 2015 ; Zhang L. et al, 2015 ; Zhang R. et al, 2015 ; Ke-Gang et al, 2016 ; Shalaby et al, 2016 ; Yang et al, 2016 , 2017 ; Zhang et al, 2016 , 2018 ; Zhu et al, 2016 ; Guo et al, 2017 ; Agiannitopoulos et al, 2018 ; Fawzy et al, 2018 ; Yi and An, 2018 ; Bukauskas et al, 2019 ; Li H. et al, 2019 ; Li P. et al, 2019 ; Xue et al, 2019a , b …”

Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

“…MicroRNA-499 rs3746444 has been proved to be signi cantly associated with increased risk of cancer of the respiratory system, digestive system,urinary system and gynecological system [42][43][44][45][46][47][48][49][50][51][52][53].Existing studies have been veri ed that the MiRNA-499(rs3746444 T > C) gene polymorphism can control the expression level of SOX gene. Due to the up-regulation of SOX6 gene, the anti-apoptosis function of MiRNA-499(rs3746444 T > C) can be reversed [54].…”