Association of rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E with Prostate Cancer: an updated meta-analysis and systematic review

Abstract

Background It has been proved that a significant proportion of prostate cancer diagnoses may be associated with a strong hereditary component. Micro-RNAs and Long Non-coding RNAs are a group of a noncoding small molecule, which play critical roles in signalling pathways, metabolism, apoptosis and cancer development. Exercising a meta-analysis to examine the relationship between rs3746444, rs3787016 and prostate cancer (PCa) risk was the main objective of our study. Results 10 case-control studies were included, while 6 on rs3787016 and 4 on rs3746444. On the whole, the genotypes carrying the T allele, in which were verified an increased risk between rs3787016 and PCa risk.( T vs C: odds ratio(OR) = 1.802, 95% CI 1.015–3.198, P value of heterogeneity(PH) = 0.00%; CT vs CC: OR = 1.179,95% CI 1.091–1.275, PH = 0.41; TT vs CC: .OR = 1.418, 95% CI 1.229–1.636, PH= 0.961; TT + CT vs CC: OR = 1.216, 95% CI 1.129–1.310, PH= 0.408; TT vs CT + CC: OR = 1.328, 95%CI 1.159–1.521, PH = 0.987). A vital relevance was performed by this meta-analysis in three models between rs3746444 and PCa risk, in which a tendency of increased PCa risk could be found (C vs T: OR = 1.197, 95% CI 1.035–1.384, PH= 0.837; CC vs TT: OR = 1. 137, 95% CI 0.813–1.590, PH = 0.392; CC + CT vs TT: OR = 1.426, 95% CI 1.166–1.743, PH= 0.406.). Conclusion Our findings proposed that rs3746444 in MiRNA-499 and rs3787016 in Long Non-coding RNAs POLR2E polymorphisms increased the risk of developing PCa. Further functional studies are warranted to reveal the role of the polymorphism in carcinogenesis.