Association of Megsin<i>2093C/T, 2180C/T</i>and<i>C25663G</i>gene polymorphism with the risk of IgA nephropathy

Mao, Song; Ren, Xiubao; Huang, Songming; Zhang, Aihua

doi:10.3109/0886022x.2014.890058

Cited by 3 publications

(6 citation statements)

References 19 publications

(30 reference statements)

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“…However, our results were consistent with the findings of previous studies, including those by Szelestei et al 20 in Hungarian population, Lim et al 18 in population of Korean descent, and Maixnerova et al 19 in a Czech population. The genotype results were similar to thosemeta-analyses by Wu et al 22 in 2011 and Mao et al 10 in 2014.…”

Section: Discussionsupporting

confidence: 90%

“… 25 Previous studies showed that megsin likely contributes to the development and/or progression of IgAN. 10 , 17 – 22 We believe that these data obtained from a Northwest Chinese population support the proposed role of megsin in IgAN.…”

Section: Discussionmentioning

confidence: 55%

“…IgAN is a multifactorial disease, and both genetic and environmental factors contribute to its pathogenesis. Although many gene polymorphisms have been reported to be associated with the development and/or progression of IgAN, 5 – 10 the precise mechanism of pathogenesis has not been elucidated.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have investigated rs1055901 and/or rs1055902, 10 , 17 – 22 and conflicting results were obtained. Therefore, whether these 2 megsin polymorphisms correlate with the development and/or progression of IgAN remains controversial.…”

Section: Introductionmentioning

confidence: 99%

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Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population

Wei

Gao³

et al. 2016

Medicine

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Megsin is a mesangial cell-predominant gene that encodes a serpin family protein which is expressed in the renal mesangium. Overexpression of megsin has been observed in the glomeruli of patients with IgA nephropathy (IgAN). The aim of this study was to evaluate the association of megsin polymorphisms (rs1055901 and rs1055902) with IgAN in a Chinese population.We examined 351 patients with histologically proven IgAN and compared them with 310 age, sex, and ethnicity-matched healthy subjects. Two single nucleotide polymorphisms (SNPs) in megsin were genotyped by Sequenom MassARRAY. SPSS 18.0 was used for statistical analyses, and SNP Stats to test for associations between these polymorphisms and IgAN risk. Odds ratios with 95% confidence intervals were used to assess the relationships.We found that rs1055901 and rs1055902 SNPs were not correlated with susceptibility to IgAN in Northwest Chinese population. Analyses of the relationship between genotypes and clinical variables indicated that in patients with IgAN, rs1055901 was associated with 24-hour proteinuria, an increase in blood pressure, and Lee's grade (P = 0.04, 0.02, and 0.04, respectively), and rs1055902 was associated with 24-hour proteinuria and Lee's grade (P = 0.03 and 0.01, respectively). However, the results showed no association between these gene variants and sex of the patients.These results indicate that megsin gene variants may play a role in the severity, development, and/or progression of IgAN in Northwest Chinese population.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population

Wei

Gao³

et al. 2016

Medicine

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“…Therefore, it is particularly important to search for genes associated with susceptibility to IgAN in order to provide a genetic target for therapeutic intervention in IgAN. There have been many Chinese studies on candidate genes associated with the severity and complications of IgAN (9)(10)(11), whereas there have been few studies looking into the candidate genes associated with its pathogenesis. A large-sample study on IgAN carried out by Li et al in China revealed that variation of the ST6GALNAC2 gene is associated with genetic susceptibility to IgAN (12).…”

Section: Introductionmentioning

confidence: 99%

Study of correlation between polymorphism of ST6GALNAC2 and susceptibility to IgA nephropathy

Chen

2015

Experimental and Therapeutic Medicine

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The aim of the present study was to explore the correlation between single nucleotide polymorphisms (SNPs) rs3840858 and rs2304921 in a specific α-2,6 sialyltransferase gene, ST6GALNAC2, and the susceptibility to immunoglobulin (IgA) nephropathy (IgAN). The distributions of genotypes of SNPs rs3840858 and rs2304921 in ST6GALNAC2 were detected by direct sequencing. The distributions of the genotype and allele frequencies of rs3840858 in patients with IgAN were significantly different from those in the control group (genotypes, P=0.001; alleles, P=0.001). The DI genotype ratio (17.8%) in the IgAN group was higher than that in the control group (5.6%) and the I allele frequency (8.9%) in the IgAN group was higher than that in the control group (2.8%). Univariate logistic regression analysis indicated that rs3840858 polymorphism is a risk factor of IgAN (P=0.001). The risk of developing IgAN in individuals who carried the DI genotype was 3-fold higher than that in individuals who carried the DD genotype [odds ratio (OR)=3.676, 95% confidence interval (CI)=1.284-10.519], and the risk of developing IgAN in individuals who carried the I allele was higher than that in individuals who carried the D allele (OR=3.415, 95% CI=1.223-9.531). The distributions of the genotype (AA, AG and GG) and allele (A and G) frequencies of rs2304921 did not have a statistically significant difference between patients with IgAN and those without (P>0.05). The SNP rs3840858 in the ST6GALNAC2 gene may be associated with the risk of developing IgAN in the population studied; however, polymorphism of rs2304921 appears to be irrelevant to the risk of developing IgAN in this population.

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Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population

Gao

et al. 2015

Genetic Testing and Molecular Biomarkers

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Association of Megsin2093C/T, 2180C/TandC25663Ggene polymorphism with the risk of IgA nephropathy

Abstract: The association between megsin 2093C

Cited by 3 publications

References 19 publications

Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population

Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population

Study of correlation between polymorphism of ST6GALNAC2 and susceptibility to IgA nephropathy

Lack of Association Between Polymorphisms in AGT and ATR1 and IgA Nephropathy in a Chinese Population

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