Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population

Wei, Linting; Fu, Rongguo; Gao, Jie; Yu, Qiaoling; Dong, Feihong; Wang, Zhe; Wang, Meng; Liu, Xinghan; Dai, Zhijun

doi:10.1097/md.0000000000002694

Cited by 2 publications

(2 citation statements)

References 23 publications

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“…A decrease in the level of Apelin-12 indicates the decline of kidney function and EMT of renal tubular cells, and progression of fibrosis in the interstitium (13)(14)(15)(16). The ROC curve results in this study show that the peptides Apelin-12, AT1R, and AGT are all sensitive to the judgment of T 0 -T 1 T 2 , and the AUC is greater than 0.7 in predicting T 0 -T 1 T 2 for Apelin-12, AT1R, and AGT.…”

Section: Discussionmentioning

confidence: 99%

Levels of Apelin-12, AT1R, and AGT are correlated with degree of renal fibrosis in patients with immunoglobulin A nephropathy

Wu¹,

Feng²,

Wang³

et al. 2021

Ann Palliat Med

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Background: To explore the relationship between the degree of renal fibrosis in patients with immunoglobulin A nephropathy (IgAN) and their levels of Apelin-12, Average Optical Density of angiotensin II type 1 receptor (AOD AT1R ), and angiotensinogen (AGT).Methods: A total of 156 patients with IgAN diagnosed by renal biopsy in our hospital were selected and divided into a T 0 group (54 cases), T 1 group (49 cases) and T 2 group (53 cases). The levels of Apelin-12, AT1R, and AGT were compared among the three groups, and the relationship between the above three indicators and degree of renal fibrosis was analyzed among patients with IgAN. Results:The AOD AT1R and AGT level in the T 2 group and T 1 groups were significantly higher than those of the T 0 group, and the Apelin-12 level of patients in the T 2 group and T 1 groups were significantly lower than that in T 0 group. Significances of the same trend were observed among all the above indicators between the T 2 group and T 1 group. ROC curves showed that when the cutoff value of Apelin-12 was 2.36 μg/L, the area under curve (AUC), sensitivity, and specificity of T 0 -T 1 T 2 were 0.889, 92.00%, and 88.00%, respectively.When the cut-off value of AOD AT1R was 0.065, the AUC, sensitivity, and specificity were 0.706, 76.00%, and 76.00%, respectively, and when the cut-off value of AGT was 47.26 ng/mL, the AUC, sensitivity, and specificity were 0.899, 84.00%, and 88.00%, respectively. When the cutoff value of Apelin-12 was 0.92 μg/L, the AUC, sensitivity, and specificity of T 0 T 1 -T 2 were 0.819, 84.62%, and 87.50%, respectively, and when the cutoff value of AOD AT1R was 0.079, the AUC, sensitivity, and specificity were 0.699, 76.92%, and 79.17%, respectively. When the cut-off value of AGT was 92.96 ng/mL, the AUC, sensitivity, and specificity were 0.893, 84.62%, and 91.67%, respectively.Conclusions: Apelin-12 decreased with disease progression, while AT1R and AGT increased. The changes of levels of Apelin-12, AT1R, and AGT have certain significance in judging the degree of renal fibrosis in patients with IgA nephropathy, and the change of level of AGT has the highest correlation with the degree of renal fibrosis.

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Section: Discussionmentioning

confidence: 99%

Levels of Apelin-12, AT1R, and AGT are correlated with degree of renal fibrosis in patients with immunoglobulin A nephropathy

Wu¹,

Feng²,

Wang³

et al. 2021

Ann Palliat Med

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“…Among these factors, genetic factors play an import role in the development and progression of IgAN [10]. Our previous studies also found that Megsin [11], MCP-1/CCR2 [12] and TLR1 [13] gene polymorphisms were associated with IgAN susceptibility in a Chinese Han population. However, the rs699 variant in AGT gene and rs5186 polymorphism in ATR1 genes did not confer the risk with IgAN [14].…”

Section: Introductionmentioning

confidence: 94%

Association Between <b><i>IFN-γ</i></b> Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

Gao¹,

Wei²,

Liu³

et al. 2017

Kidney Blood Press Res

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Background/Aims: IFN-γ was reported to be involved in the development and progression of Immunoglobulin A nephropathy (IgAN), however, few studies have investigated the association between IFN-γ polymorphisms and IgAN. Therefore, we performed a case-control study to assess the association between IFN-γ polymorphisms and the risk of IgAN. Methods: Sequenom MassARRAY was used to genotype two SNPs (rs1861494 and rs2430561) in 351 patients with IgAN and 310 healthy controls. Associations were evaluated as odd ratios (OR) with 95% confidence intervals (CI). Results: No association was found between IFN-γ rs1861494 and IgAN risk or clinical parameters. For rs2430561, the AA genotype was more common in patients with IgAN, compared with controls (AT vs. AA: OR = 0.57, P = 0.035). IFN-γ-rs2430561 T allele may be a protective factor for IgAN susceptibility (T vs. A: OR = 0.59, P = 0.04). Subgroup analysis based on clinical features revealed no significant association between rs2430561 polymorphism and clinical data such as gender, 24-h urine protein, blood pressure, Oxford classifcation and estimated glomerular fltration rate. IgAN patients had a higher IFN-γ serum level than healthy controls and patients with rs1861494 AA genotype had a higher IFN-γ serum level compared with those with AG/GG genotypes. Conclusions: IFN-γ polymorphisms may be involved in the development and progression of IgAN.

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Association of Megsin Gene Variants With IgA Nephropathy in Northwest Chinese Population

Cited by 2 publications

References 23 publications

Levels of Apelin-12, AT1R, and AGT are correlated with degree of renal fibrosis in patients with immunoglobulin A nephropathy

Levels of Apelin-12, AT1R, and AGT are correlated with degree of renal fibrosis in patients with immunoglobulin A nephropathy

Association Between <b><i>IFN-γ</i></b> Gene Polymorphisms and IgA Nephropathy in a Chinese Han Population

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